Gut-liver axis: Pathophysiological concepts and clinical implications

Cell Metabolism, Год журнала: 2022, Номер 34(11), С. 1700 - 1718

Опубликована: Окт. 7, 2022

Язык: Английский

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The intestinal barrier in disorders of the central nervous system

˜The œLancet. Gastroenterology & hepatology, Год журнала: 2022, Номер 8(1), С. 66 - 80

Опубликована: Ноя. 2, 2022

Язык: Английский

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Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases

Seminars in Immunology, Год журнала: 2024, Номер 71, С. 101859 - 101859

Опубликована: Янв. 21, 2024

Язык: Английский

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Targeting cytokines in inflammatory bowel disease

Science Translational Medicine, Год журнала: 2022, Номер 14(675)

Опубликована: Дек. 14, 2022

Targeting cytokines in inflammatory bowel disease (IBD) is a useful clinical approach. Potential therapies for IBD include regulatory T cell transfer to restore cytokine balance, blocking proinflammatory (e.g., IL-12 and IL-23) or their receptors (sIL-6R IL-36R), inhibiting signaling kinases JAK). An emerging trend therapy combine several anti-cytokine agents simultaneously.

Язык: Английский

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Understanding disruption of the gut barrier during inflammation: Should we abandon traditional epithelial cell lines and switch to intestinal organoids?

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 16, 2023

Disruption of the intestinal epithelial barrier is a hallmark mucosal inflammation. It increases exposure immune system to luminal microbes, triggering perpetuating inflammatory response. For several decades, stimuli-induced breakdown human gut was studied in vitro by using colon cancer derived cell lines. While providing wealth important data, these lines do not completely mimic morphology and function normal cells (IEC) due cancer-related chromosomal abnormalities oncogenic mutations. The development organoids provided physiologically-relevant experimental platform study homeostatic regulation disease-dependent dysfunctions barrier. There need align integrate emerging data obtained with classical studies that utilized This review discusses utilization dissect roles mechanisms disruption during We summarize available generated two major types from either crypts or induced pluripotent stem compare them results earlier conventional identify research areas where complementary use cancer-derived advance our understanding inflamed unique questions could be addressed only organoid platforms.

Язык: Английский

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Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients

Molecular Psychiatry, Год журнала: 2023, Номер 28(10), С. 4421 - 4437

Опубликована: Авг. 21, 2023

Язык: Английский

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Inflammation, Autoinflammation and Autoimmunity in Inflammatory Bowel Diseases

Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(7), С. 5534 - 5557

Опубликована: Июнь 30, 2023

In this review, the role of innate and adaptive immunity in pathogenesis inflammatory bowel diseases (IBD) is reported. IBD, an altered often found, with increased Th17 decreased Treg cells infiltrating intestinal mucosa. An associated increase cytokines, such as IL-1 TNF-α, a decrease anti-inflammatory IL-10, concur favoring persistent inflammation gut Autoinflammation highlighted insights inflammasomes, which activation by exogenous or endogenous triggers might be favored mutations NOD NLRP proteins. Autoimmunity mechanisms also take place IBD context immune stimulation bacterial antigens derived from degradation, response takes results antibodies autoantibodies production, frequent finding these diseases. Inflammation, autoinflammation autoimmunity altering mucus layer enhancing permeability, sustains vicious cycle further mucosal inflammation.

Язык: Английский

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G-MDSC-derived exosomes mediate the differentiation of M-MDSC into M2 macrophages promoting colitis-to-cancer transition

Journal for ImmunoTherapy of Cancer, Год журнала: 2023, Номер 11(6), С. e006166 - e006166

Опубликована: Июнь 1, 2023

In inflammatory bowel disease microenvironment, transdifferentiation of myeloid-derived suppressor cells (MDSCs) and M2 macrophage accumulation are crucial for the transition colitis-to-cancer. New insights into cross-talk underling mechanism between MDSCs during colitis-to-cancer opening new avenues colitis-associated cancer (CAC) prevention treatment.The role underlying that granulocytic (G-MDSCs) or exosomes (Exo) regulates differentiation monocytic (M-MDSCs) macrophages were investigated using immunofluorescence, FACS, IB analysis, etc, employing siRNA antibodies. vivo efficacy mechanistic studies conducted with dextran sulfate sodium-induced CAC mice, employed IL-6 Abs STAT3 inhibitor.G-MDSCs promote M-MDSC through exosomal miR-93-5 p which downregulating activity in M-MDSC. is responsible enrichment G-MDSC (GM-Exo). Mechanistically, chronic inflammation-driven synthesis via IL-6R/JAK/STAT3 pathway. Early use enhances effect inhibitor against CAC.IL-6-driven secretion promotes involves a signaling transition. Combining inhibitors strategies inhibit IL-6-mediated production beneficial treatment CAC.

Язык: Английский

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The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions

Seminars in Immunology, Год журнала: 2023, Номер 70, С. 101846 - 101846

Опубликована: Окт. 4, 2023

Since the 1960 s, our health has been compromised by exposure to over 350,000 newly introduced toxic substances, contributing current pandemic in allergic, autoimmune and metabolic diseases. The "Epithelial Barrier Theory" postulates that these diseases are exacerbated persistent periepithelial inflammation (epithelitis) triggered a wide range of epithelial barrier-damaging substances as well genetic susceptibility. barrier serves body's primary physical, chemical, immunological against external stimuli. A leaky facilitates translocation microbiome from surface afflicted tissues interepithelial even deeper subepithelial locations. In turn, opportunistic bacterial colonization, microbiota dysbiosis, local impaired tissue regeneration remodelling follow. Migration inflammatory cells susceptible contributes damage inflammation, initiating aggravating many chronic objective this review is highlight evaluate recent studies on physiology its role pathogenesis light theory.

Язык: Английский

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Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”

Journal of Advanced Research, Год журнала: 2023, Номер 55, С. 159 - 171

Опубликована: Фев. 22, 2023

Mastitis is an inflammatory response in the mammary gland that results huge economic losses breeding industry. The aetiology of mastitis complex, and pathogenesis has not been fully elucidated. It commonly believed induced by pathogen infection induces a local response. However, clinic, often comorbid or secondary to gastric disease, control effects targeting are limited. In addition, recent studies have found gut/rumen microbiota contributes development proposed gut/rumen–mammary axis. Combined with indicating disturbance can damage gut mucosa barrier, bacteria their metabolites migrate distal extraintestinal organs. occurrence related only external pathogenic microorganisms but also gastroenterogennic pathway. We propose pathological concept "gastroenterogennic mastitis" believe axis–mediated pathway mechanism mastitis". To clarify summarizing reports on effect provide research basis direction for further understanding solving difficulties encountered prevention mastitis.

Язык: Английский

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