Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications

Journal of Hazardous Materials, Год журнала: 2022, Номер 437, С. 129361 - 129361

Опубликована: Июнь 16, 2022

Язык: Английский

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The potential toxicity of microplastics on human health

The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 168946 - 168946

Опубликована: Дек. 2, 2023

Язык: Английский

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Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut–Liver Axis

ACS Nano, Год журнала: 2023, Номер 17(15), С. 15125 - 15145

Опубликована: Июль 24, 2023

Dietary pollution by polystyrene microplastics (MPs) can cause hepatic injuries and microbial dysbiosis. Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, exerts beneficial effects on liver modulating gut microbiota. However, role of microbiota MPs-induced protective effect EGCG have not been clarified. Here, 5 μm MPs were orally administered to mice induce injuries. Subsequently, antibiotic cocktail (ABX) fecal transplant (FMT) experiments performed investigate underlying mechanisms. Additionally, was explore its protection against Our results showed that activated systemic inflammation, promoted fibrosis, altered metabolome; meanwhile, damaged homeostasis disturbing microbiome, promoting colonic impairing intestinal barrier. Notably, reduced abundance probiotics Akkermansia, Mucispirillum, Faecalibaculum while increasing pathogenic Tuzzerella. Interestingly, elimination mitigated inflammation barrier impairment. Moreover, ABX ameliorated but fibrosis. Correspondingly, from MPs-administered induced colonic, systemic, their profibrosis observed. Finally, elevated effectively repressed inflammation. remodeling metabolome also attenuated EGCG. These findings illustrated contributed injuries, could serve as a potential prevention strategy for these adverse consequences.

Язык: Английский

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A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health

Eco-Environment & Health, Год журнала: 2023, Номер 2(4), С. 195 - 207

Опубликована: Авг. 21, 2023

Micro- and nano-plastics (MNPs) pollution has become a pressing global environmental issue, with growing concerns regarding its impact on human health. However, evidence the effects of MNPs health remains limited. This paper reviews three routes exposure to MNPs, which include ingestion, inhalation, dermal contact. It further discusses potential translocation in lungs, intestines, skin, analyses homeostasis organ systems, provides an outlook future research priorities for There is that are present tissues or fluids. Lab studies, including

Язык: Английский

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Polystyrene microplastics induce size-dependent multi-organ damage in mice: Insights into gut microbiota and fecal metabolites

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132503 - 132503

Опубликована: Сен. 6, 2023

Язык: Английский

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Global face mask pollution: threats to the environment and wildlife, and potential solutions

The Science of The Total Environment, Год журнала: 2023, Номер 887, С. 164055 - 164055

Опубликована: Май 11, 2023

Язык: Английский

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The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways

Journal of Hazardous Materials, Год журнала: 2023, Номер 458, С. 131949 - 131949

Опубликована: Июнь 29, 2023

Язык: Английский

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Oxidative stress and potential effects of metal nanoparticles: A review of biocompatibility and toxicity concerns

Environmental Pollution, Год журнала: 2024, Номер 346, С. 123617 - 123617

Опубликована: Фев. 21, 2024

Язык: Английский

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Acute Exposure to Microplastics Induced Changes in Behavior and Inflammation in Young and Old Mice

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(15), С. 12308 - 12308

Опубликована: Авг. 1, 2023

Environmental pollutants have become quite ubiquitous over the past two centuries; of those, plastics, and in particular, microplastics (<5 mm), are among most pervasive pollutants. Microplastics (MPs) found their way into air, water system, food chain either purposely produced or derived from breakdown larger plastic materials. Despite societal advancements that plastics allowed, mismanagement waste has a pressing global issue. Pioneering studies on MPs toxicity shown exposure to induces oxidative stress, inflammation, decreased cell viability marine organisms. Current research suggests these transported throughout environment can accumulate human tissues; however, health effects MPs, especially mammals, is still very limited. This led our group explore biological cognitive consequences rodent model. Following three-week treated with fluorescently-labeled pristine polystyrene young old C57BL/6J mice were assessed using behavioral assays, such as open-field light-dark preference, followed by tissue analyses fluorescent immunohistochemistry, Western blot, qPCR. Data assays suggest short-term both changes well alterations immune markers liver brain tissues. Additionally, we noted differed depending age, indicating possible age-dependent effect. These findings need for further better understand mechanisms which may induce physiological changes.

Язык: Английский

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Food chain microplastics contamination and impact on human health: a review

Environmental Chemistry Letters, Год журнала: 2024, Номер 22(4), С. 1889 - 1927

Опубликована: Апрель 9, 2024

Язык: Английский

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