Neurobiology of Disease,
Год журнала:
2023,
Номер
179, С. 106033 - 106033
Опубликована: Фев. 8, 2023
Research
in
the
last
decade
has
unveiled
a
crucial
role
for
trillions
of
microorganisms
that
reside
gut
influencing
host
neurodevelopment
across
lifespan
via
microbiota-gut-brain
axis.
Studies
have
linked
alterations
composition,
complexity,
and
diversity
microbiota
to
changes
behaviour
including
abnormal
social
interactions,
cognitive
deficits,
anxiety-
depressive-like
phenotypes.
Moreover,
been
with
neurodevelopmental,
neuropsychiatric,
neurodegenerative
disorders.
Interestingly,
there
appears
be
specific
brain
regions
governing
neurocircuitry
driving
higher
function
are
susceptible
influence
from
manipulations
microbiome.
This
review
will
aim
elucidate
region-specific
effects
mediated
by
microbiota,
focus
on
translational
animal
models
some
existing
human
neuroimaging
data.
Compelling
preclinical
evidence
suggests
disruption
normal
signalling
can
detrimental
prefrontal
cortex,
amygdala,
hippocampus,
hypothalamus,
striatum.
Furthermore,
studies
mediating
functional
connectivity
structure
traced
back
neurocognition
behavioural
output.
Understanding
these
microbiota-mediated
aid
identifying
unique
therapeutic
targets
treating
neurological
disorders
associated
regions.
Science Immunology,
Год журнала:
2024,
Номер
9(93)
Опубликована: Март 15, 2024
The
gut
microbiota
promotes
immune
system
development
in
early
life,
but
the
interactions
between
metabolome
and
cells
neonatal
remain
largely
undefined.
Here,
we
demonstrate
that
is
uniquely
enriched
with
neurotransmitters,
including
serotonin,
specific
bacteria
directly
produce
serotonin
while
down-regulating
monoamine
oxidase
A
to
limit
breakdown.
We
found
signals
T
increase
intracellular
indole-3-acetaldehdye
inhibit
mTOR
activation,
thereby
promoting
differentiation
of
regulatory
cells,
both
ex
vivo
intestine.
Oral
gavage
into
mice
resulted
long-term
cell-mediated
antigen-specific
tolerance
toward
dietary
antigens
commensal
bacteria.
Together,
our
study
has
uncovered
an
important
role
for
availability
identified
a
function
shaping
cell
response
promote
life.
Brain Research Bulletin,
Год журнала:
2024,
Номер
216, С. 111056 - 111056
Опубликована: Авг. 24, 2024
The
intricate
interplay
existing
between
gut
microbiota
and
homeostasis
extends
to
the
realm
of
brain,
where
emerging
research
underscores
significant
impact
on
mood
regulation
overall
neurological
well-being
vice-versa,
with
inflammation
playing
a
pivotal
role
in
mediating
these
complex
interactions.
This
comprehensive
review
explores
inflammation,
alterations
microbiota,
their
major
depressive
disorder
(MDD).
It
provides
cohesive
framework
for
puzzle
pieces
this
triad,
emphasizing
recent
advancements
understanding
inflammatory
states'
contribution
features.
Two
directions
communication
brain
depression
are
discussed,
serving
as
potential
modulator.
Therapeutic
implications
were
discussed
well,
drawing
insights
from
interventional
studies
effects
probiotics
bacterial
composition
symptoms.
Ultimately,
will
attempt
provide
complete
valuable
future
therapeutic
interventions
MDD.
