Biochemical Journal,
Год журнала:
2022,
Номер
479(16), С. 1653 - 1708
Опубликована: Авг. 31, 2022
Ischaemia-reperfusion
(I-R)
injury,
initiated
via
bursts
of
reactive
oxygen
species
produced
during
the
reoxygenation
phase
following
hypoxia,
is
well
known
in
a
variety
acute
circumstances.
We
argue
here
that
I-R
injury
also
underpins
elements
pathology
chronic,
inflammatory
diseases,
including
rheumatoid
arthritis,
ME/CFS
and,
our
chief
focus
and
most
proximally,
Long
COVID.
Ischaemia
may
be
fibrin
amyloid
microclot
blockage
capillaries,
for
instance
as
exercise
started;
reperfusion
necessary
corollary
when
it
finishes.
rehearse
mechanistic
evidence
these
occurrences
here,
terms
their
manifestation
oxidative
stress,
hyperinflammation,
mast
cell
activation,
production
marker
metabolites
related
activities.
Such
microclot-based
phenomena
can
explain
both
breathlessness/fatigue
post-exertional
malaise
observed
conditions,
many
other
observables.
The
recognition
processes
implies,
mechanistically,
therapeutic
benefit
potentially
to
had
from
antioxidants,
anti-inflammatories,
iron
chelators,
suitable,
safe
fibrinolytics,
and/or
anti-clotting
agents.
review
considerable
existing
consistent
with
this,
biochemical
mechanisms
involved.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2021,
Номер
11
Опубликована: Дек. 7, 2021
Periodontal
disease
is
classically
characterized
by
progressive
destruction
of
the
soft
and
hard
tissues
periodontal
complex,
mediated
an
interplay
between
dysbiotic
microbial
communities
aberrant
immune
responses
within
gingival
tissues.
Putative
pathogens
are
enriched
as
resident
oral
microbiota
becomes
inflammatory
evoke
tissue
destruction,
thus
inducing
unremitting
positive
feedback
loop
proteolysis,
inflammation,
enrichment
for
pathogens.
Keystone
sustained
inflammation
critical
to
progression.
However,
recent
studies
have
revealed
importance
previously
unidentified
microbes
involved
in
progression,
including
various
viruses,
phages
bacterial
species.
Moreover,
newly
identified
immunological
genetic
mechanisms,
well
environmental
host
factors,
diet
lifestyle,
been
discerned
years
further
contributory
factors
periodontitis.
These
collectively
expanded
established
narrative
In
line
with
this,
new
ideologies
related
maintaining
health
treating
existing
explored,
such
application
probiotics,
limit
attenuate
The
role
systemic
pathologies,
autoimmune
disorders
diabetes,
pathogenesis
has
noted.
Recent
additionally
reciprocated
potentiating
states
at
distal
sites,
Alzheimer’s
disease,
bowel
diseases,
cancer,
highlighting
cavity
health.
Here
we
review
long-standing
knowledge
progression
while
integrating
novel
research
concepts
that
broadened
our
understanding
disease.
Further,
delve
into
innovative
hypotheses
may
evolve
address
significant
gaps
foundational
Abstract
Background
The
gut
microbiota
is
reportedly
involved
in
the
progression
and
chemoresistance
of
various
human
malignancies.
However,
underlying
mechanisms
behind
how
it
exerts
some
effect
on
prostate
cancer,
as
an
extra-intestinal
tumor,
a
contact-independent
way
remain
elusive
deserve
exploration.
Antibiotic
exposure,
one
factors
affecting
community
capable
causing
dysbiosis,
associated
with
multiple
disorders.
This
study
aims
to
preliminarily
clarify
link
between
dysbiosis
cancer.
Results
First,
we
discovered
that
perturbing
by
consuming
broad-spectrum
antibiotics
water
promoted
growth
subcutaneous
orthotopic
tumors
mice.
Fecal
transplantation
could
transmit
antibiotic
exposure
tumor
growth.
Then,
16S
rRNA
sequencing
for
mouse
feces
indicated
relative
abundance
Proteobacteria
was
significantly
higher
after
exposure.
Meanwhile,
intratumoral
lipopolysaccharide
(LPS)
profoundly
increased
under
elevation
permeability.
Both
vivo
vitro
experiments
revealed
NF-κB-IL6-STAT3
axis
activated
LPS
facilitated
cancer
proliferation
docetaxel
chemoresistance.
Finally,
patients’
fecal
samples
enriched
patients
metastatic
positively
correlated
plasma
IL6
level,
regional
lymph
node
metastasis
status,
distant
status.
receiver
operating
characteristic
(ROC)
curves
showed
had
better
performance
than
prostate-specific
antigen
(PSA)
level
predicting
probability
(area
ROC
curve,
0.860;
p
<
0.001).
Conclusion
Collectively,
this
research
demonstrated
characterized
enrichment
due
resulted
permeability
LPS,
promoting
development
via
Considering
findings
from
patients,
might
act
intestinal
biomarker
progressive
Journal of Controlled Release,
Год журнала:
2022,
Номер
353, С. 1107 - 1126
Опубликована: Дек. 25, 2022
Colonic
drug
delivery
can
facilitate
access
to
unique
therapeutic
targets
and
has
the
potential
enhance
bioavailability
whilst
reducing
off-target
effects.
Delivering
drugs
colon
requires
considered
formulation
development,
as
both
oral
rectal
dosage
forms
encounter
challenges
if
colon's
distinct
physiological
environment
is
not
appreciated.
As
opportunities
surrounding
colonic
multiply,
success
of
novel
pharmaceuticals
lies
in
their
design.
This
review
provides
a
modern
insight
into
key
parameters
determining
effective
design
development
colon-targeted
medicines.
Influential
features
governing
release,
dissolution,
stability,
absorption
are
first
discussed,
followed
by
an
overview
most
reliable
strategies.
Finally,
appropriate
vitro,
vivo,
silico
preclinical
investigations
presented,
with
goal
inspiring
strategic
new
therapeutics.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
254, С. 114734 - 114734
Опубликована: Март 10, 2023
Antibiotic
resistance
is
currently
one
of
the
greatest
threats
to
human
health.
Widespread
use
and
residues
antibiotics
in
humans,
animals,
environment
can
exert
selective
pressure
on
antibiotic
bacteria
(ARB)
gene
(ARG),
accelerating
flow
resistance.
As
ARG
spreads
population,
burden
humans
increases,
which
may
have
potential
health
effects
people.
Therefore,
it
critical
mitigate
spread
reduce
load
humans.
This
review
briefly
described
information
global
consumption
national
action
plans
(NAPs)
combat
provided
a
set
feasible
control
strategies
for
transmission
ARB
three
areas
including
(a)
Reducing
colonization
capacity
exogenous
ARB,
(b)
Enhancing
mitigating
horizontal
transfer
(HGT)
ARG,
(c)
Reversing
With
hope
achieving
interdisciplinary
one-health
prevention
bacterial
ACS Nano,
Год журнала:
2022,
Номер
16(7), С. 10066 - 10087
Опубликована: Июль 1, 2022
Antibiotic
resistance
has
become
a
serious
threat
to
human
health
due
the
overuse
of
antibiotics.
Different
antibiotics
are
being
developed
treat
resistant
bacteria,
but
development
cycle
is
hard
keep
up
with
high
incidence
antibiotic
resistance.
Recent
advances
in
antimicrobial
nanomaterials
have
made
nanotechnology
powerful
solution
this
dilemma.
Among
these
nanomaterials,
gold
excellent
antibacterial
efficacy
and
biosafety,
making
them
alternatives
This
review
presents
strategies
that
use
combat
drug-resistant
bacteria.
We
focus
on
influence
physicochemical
factors
such
as
surface
chemistry,
size,
shape
their
properties
describe
applications
medical
devices.
Finally,
existing
challenges
future
directions
discussed.
