Neuron, Год журнала: 2025, Номер 113(8), С. 1124 - 1126
Опубликована: Апрель 1, 2025
Язык: Английский
Cell, Год журнала: 2023, Номер 186(1), С. 178 - 193.e15
Опубликована: Янв. 1, 2023
The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA VMHvl, respectively. Here, we perform dynamical systems modeling population activity in these nuclei during behaviors. In unsupervised analysis identified a dominant dimension neural with large time constant (>50 s), generating an approximate line attractor state space. Progression the trajectory along this was correlated escalation agonistic behavior, suggesting that it may encode scalable aggressiveness. Consistent this, individual differences magnitude integration were strongly contrast, attractors not observed mating; instead, neurons fast dynamics tuned to actions. Thus, different hypothalamic employ distinct codes represent similar
Язык: Английский
Процитировано
76
Nature, Год журнала: 2023, Номер 618(7967), С. 1006 - 1016
Опубликована: Июнь 7, 2023
Язык: Английский
Процитировано
44
Science, Год журнала: 2023, Номер 382(6669), С. 399 - 404
Опубликована: Окт. 26, 2023
Sexual, parental, and aggressive behaviors are central to the reproductive success of individuals species survival thus supported by hardwired neural circuits. The behavior control column (RBCC), which comprises medial preoptic nucleus (MPN), ventrolateral part ventromedial hypothalamus (VMHvl), ventral premammillary (PMv), is essential for all social behaviors. RBCC integrates diverse hormonal metabolic cues adjusts an animal's physical activity, hence chance encounters. further engages mesolimbic dopamine system maintain interest reinforces actions that time-locked with We propose brainstem form a dual-control generating moment-to-moment actions. This Review summarizes recent progress regarding identities cells their pathways drive different aspects
Язык: Английский
Процитировано
44
Cell, Год журнала: 2023, Номер 186(18), С. 3862 - 3881.e28
Опубликована: Авг. 1, 2023
Male sexual behavior is innate and rewarding. Despite its centrality to reproduction, a molecularly specified neural circuit governing male reward remains be characterized. We have discovered developmentally wired necessary sufficient for mating. This connects chemosensory input BNSTprTac1 neurons, which innervate POATacr1 neurons that project centers regulating motor output reward. Epistasis studies demonstrate are upstream of BNSTprTac1-released substance P following mate recognition potentiates activation through Tacr1 initiate Experimental triggers mating, even in sexually satiated males, it rewarding, eliciting dopamine release self-stimulation these cells. Together, we uncovered governs the key aspects behavior: displays, drive,
Язык: Английский
Процитировано
43
Cell, Год журнала: 2023, Номер 186(6), С. 1195 - 1211.e19
Опубликована: Фев. 15, 2023
Social interactions require awareness and understanding of the behavior others. Mirror neurons, cells representing an action by self others, have been proposed to be integral cognitive substrates that enable such understanding. neurons primate neocortex represent skilled motor tasks, but it is unclear if they are critical for actions embody, social behaviors, or exist in non-cortical regions. We demonstrate activity individual VMHvl
Язык: Английский
Процитировано
36
Science, Год журнала: 2023, Номер 379(6634), С. 820 - 825
Опубликована: Фев. 9, 2023
Transient sexual experiences can have long-lasting effects on behavioral decisions, but the neural coding that accounts for this change is unclear. We found ejaculation experience selectively activated estrogen receptor 2 (Esr2)-expressing neurons in bed nucleus of stria terminalis (BNST)-BNSTEsr2-and led to persistent decreases firing threshold days, during which time mice displayed satiety. Inhibition hyperexcited BNSTEsr2 elicited fast mating recovery satiated both sexes. In males, such hyperexcitability reduced motivation and was partially mediated by larger HCN (hyperpolarization-activated cyclic nucleotide-gated) currents. Thus, not only encode a specific action also represent state satiety, alterations neuronal ion channel contribute experience-dependent long-term changes drive.
Язык: Английский
Процитировано
33
Neuron, Год журнала: 2023, Номер 111(20), С. 3288 - 3306.e4
Опубликована: Авг. 15, 2023
Язык: Английский
Процитировано
32
Nature Neuroscience, Год журнала: 2023, Номер 26(5), С. 774 - 787
Опубликована: Апрель 10, 2023
Язык: Английский
Процитировано
27
Neuron, Год журнала: 2024, Номер 112(9), С. 1498 - 1517.e8
Опубликована: Март 1, 2024
Recognizing the affective states of social counterparts and responding appropriately fosters successful interactions. However, little is known about how are expressed perceived they influence decisions. Here, we show that male female mice emit distinct olfactory cues after experiencing distress. These activate neural circuits in piriform cortex (PiC) evoke sexually dimorphic empathic behaviors observers. Specifically, PiC → PrL pathway activated observers, inducing a preference for distressed counterpart. Conversely, MeA evoking excessive self-grooming behaviors. pathways originate from non-overlapping neuron populations with gene expression signatures regulated by transcription factors sex hormones. Our study unveils internal processed through mechanisms at molecular, cellular, circuit levels offers insights into underpinning differences higher brain functions.
Язык: Английский
Процитировано
15
Nature Neuroscience, Год журнала: 2024, Номер 27(4), С. 702 - 715
Опубликована: Фев. 12, 2024
Язык: Английский
Процитировано
12