Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер 35(6), С. 518 - 532
Опубликована: Янв. 10, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 254, С. 127955 - 127955
Опубликована: Ноя. 7, 2023
Язык: Английский
Процитировано
153
Cancer and Metastasis Reviews, Год журнала: 2023, Номер 43(1), С. 29 - 53
Опубликована: Июль 15, 2023
Язык: Английский
Процитировано
46
Nature, Год журнала: 2024, Номер 635(8039), С. 746 - 754
Опубликована: Ноя. 6, 2024
Язык: Английский
Процитировано
38
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Фев. 27, 2024
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This due to the fact that most cases are only diagnosed at advanced and palliative stage, there a high incidence of therapy resistance. Despite ongoing efforts, date, mechanisms underlying PDAC oncogenesis its responses treatment still largely unclear. As study microbiome in cancer progresses, growing evidence suggests bacteria or fungi might be key players both as well resistance chemo- immunotherapy, for instance through modulation tumor microenvironment reshaping host immune response. Here, we review how microbiota exerts these effects directly indirectly via microbial-derived metabolites. Finally, further discuss potential modulating composition PDAC.
Язык: Английский
Процитировано
21
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Июль 29, 2024
Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming amino acids cells is intricately linked to protein synthesis, nucleotide modulation signaling pathways, regulation cell metabolism, maintenance oxidative stress homeostasis, and epigenetic modifications. Furthermore, the dysregulation also impacts microenvironment immunity. can act as molecules that modulate immune function tolerance within reshaping anti-tumor response promoting evasion by cells. Moreover, influence behavior stromal cells, such cancer-associated fibroblasts, regulate ECM remodeling promote angiogenesis, thereby facilitating growth metastasis. Understanding intricate interplay between crucial significance. Expanding our knowledge multifaceted roles holds significant promise for development more effective therapies aimed at disrupting dependencies modulating enhance responses inhibit
Язык: Английский
Процитировано
19
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(13)
Опубликована: Март 21, 2024
Polyamines are a class of small polycationic alkylamines that play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated considered therapeutic target cancer. However, targeting polyamine as monotherapy often exhibits limited efficacy, the underlying mechanisms incompletely understood. Here we report activation catabolism promotes glutamine metabolism, leading to targetable vulnerability lung Genetic pharmacological spermidine/spermine N1-acetyltransferase 1 (SAT1), rate-limiting enzyme catabolism, enhances conversion glutamate subsequent glutathione (GSH) synthesis. This metabolic rewiring ameliorates oxidative stress support proliferation survival. Simultaneous limitation SAT1 result ROS accumulation, growth inhibition, death. Importantly, inhibition either one transport, glutaminase, or GSH biosynthesis combination with synergistically suppresses xenograft tumor formation. Together, this study unveils previously unappreciated functional interconnection between establishes cotargeting strategies potential therapeutics
Язык: Английский
Процитировано
16
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 11, 2025
The Kirsten rat sarcoma viral oncogene homolog (KRAS) protein plays a key pathogenic role in oncogenesis, cancer progression, and metastasis. Numerous studies have explored the of metabolic alterations KRAS-driven cancers, providing scientific rationale for targeting metabolism treatment. development KRAS-specific inhibitors has also garnered considerable attention, partly due to challenge acquired treatment resistance. Here, we review reprogramming glucose, glutamine, lipids regulated by oncogenic KRAS, with an emphasis on recent insights into relationship between changes mechanisms driven KRAS mutant related advances targeted therapy. We focus inhibitor discovery strategies colorectal, pancreatic, non-small cell lung cancer, including current clinical trials. Therefore, this provides overview understanding associated mutation therapeutic strategies, aiming facilitate challenges support investigation strategies.
Язык: Английский
Процитировано
4
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 13, 2025
Abstract KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis fatty acids nucleotides. However, beyond mechanisms KRAS-modulated cancer metabolisms remain incompletely understood. In this review, we aim to summarize current knowledge on KRAS-related alterations cells explore prevalence significance mutation shaping tumor microenvironment influencing epigenetic modification via various molecular activities. Given rely these changes sustain cell growth survival, targeting processes may represent a promising therapeutic strategy for KRAS-driven cancers.
Язык: Английский
Процитировано
4
Trends in Pharmacological Sciences, Год журнала: 2024, Номер 45(5), С. 395 - 405
Опубликована: Апрель 5, 2024
Язык: Английский
Процитировано
15
Trends in Molecular Medicine, Год журнала: 2024, Номер 30(6), С. 592 - 604
Опубликована: Апрель 10, 2024
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as key factor in tumor initiation, progression, therapy resistance has gained prominence. In this review we the impact changes interplay among stromal, immune, cells, glutamine branched-chain amino acids (BCAAs) emerge pivotal players modulating immune cell functions growth. We also discuss ongoing clinical trials that explore modulation PDAC, targeting mitochondrial metabolism, asparagine addiction, autophagy inhibition. Overcoming challenges understanding nutrient effects immune-stromal-tumor interactions holds promise innovative therapeutic strategies.
Язык: Английский
Процитировано
14