Immune imprinting: The persisting influence of the first antigenic encounter with rapidly evolving viruses DOI Creative Commons
Mariam Maltseva, Alexa Keeshan, Curtis Cooper

и другие.

Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)

Опубликована: Авг. 16, 2024

Immune imprinting is a phenomenon that stems from the fundamentals of immunological memory. Upon recurrent exposures to an evolving pathogen, immune system must weigh benefits rapidly recalling established antibody repertoires with greater affinity initial variant or invest additional time and energy in producing de novo responses specific emerging variant. In this review, we delve into mechanistic complexities its role shaping subsequent responses, both recall, against respiratory viruses such as influenza coronaviruses. By exploring duality imprinting, examine potential enhance hinder protection disease, while emphasizing host viral factors. Finally, explore how different vaccine platforms may affect comment on strategies can favor variant-specific responses.

Язык: Английский

mRNA vaccines for infectious diseases — advances, challenges and opportunities DOI
Norbert Pardi, Florian Krammer

Nature Reviews Drug Discovery, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Язык: Английский

Процитировано

14
XBB.1.5 monovalent booster improves antibody binding and neutralization against emerging SARS-CoV-2 Omicron variants DOI Open Access
Shilpi Jain, Sanjeev Kumar, Lilin Lai

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 5, 2024

Abstract The rapid emergence of divergent SARS-CoV-2 variants has led to an update the COVID-19 booster vaccine a monovalent version containing XBB.1.5 spike. To determine neutralization breadth following immunization, we collected blood samples from 24 individuals pre- and post-XBB.1.5 mRNA vaccination (∼1 month). improved both neutralizing activity against ancestral strain (WA1) circulating Omicron variants, including EG.5.1, HK.3, HV.1, JN.1. Relative pre-boost titers, induced greater total IgG subclass binding, particular IgG4, spike as compared WA1 We evaluated antigen-specific memory B cells (MBCs) using either or receptor binding domain (RBD) probes found that largely increases non-RBD cross-reactive MBCs. These data suggest induces antibodies neutralize related variants.

Язык: Английский

Процитировано

11
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans DOI Open Access
Lilit Grigoryan, Yupeng Feng, Lorenza Bellusci

и другие.

Science Immunology, Год журнала: 2024, Номер 9(94)

Опубликована: Апрель 5, 2024

Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is due to generation antigen-specific B cell clones with distinct specificities or maturation memory that produce broadly cross-reactive antibodies unknown. Here, we longitudinally analyzed immune responses in healthy adults after two-dose vaccination either a virus-like particle COVID-19 vaccine (CoVLP), CoVLP adjuvanted AS03 (CoVLP+AS03), messenger RNA (mRNA-1273). CoVLP+AS03 enhanced magnitude and durability circulating CD4 + T responses. Antigen-specific cells group at day 42 correlated 6 months. induced which accumulated somatic hypermutations over months, resulting neutralization monoclonal antibodies. Furthermore, fraction neutralizing encoded by increased between These results indicate enhances antigenic clonal level induces progressive response.

Язык: Английский

Процитировано

10
Original COVID-19 priming regimen impacts the immunogenicity of bivalent BA.1 and BA.5 boosters DOI Creative Commons
Luca M. Zaeck, Ngoc H. Tan, Wim J. R. Rietdijk

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Май 18, 2024

Abstract Waning antibody responses after COVID-19 vaccination combined with the emergence of SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness. As a countermeasure, bivalent mRNA-based booster vaccines encoding ancestral spike protein in combination that BA.1 or BA.5 were introduced. Since then, different BA.2-descendent lineages have become dominant, such as XBB.1.5, JN.1, EG.5.1. Here, we report post-hoc analyses data from SWITCH-ON study, assessing how priming regimens affect immunogenicity vaccinations and breakthrough infections (NCT05471440). boosted neutralizing antibodies T-cells up 3 months boost; however, cross-neutralization XBB.1.5 was poor. Interestingly, combinations prime-boost induced divergent responses: participants primed Ad26.COV2.S developed lower binding levels boost while neutralization T-cell similar participants. In contrast, breadth higher mRNA-primed Combined, our further support current use monovalent based on circulating strains when vaccinating risk groups, recently recommended by WHO. We emphasize importance continuous assessment immune targeting variants guide future policies.

Язык: Английский

Процитировано

9
Immune imprinting: The persisting influence of the first antigenic encounter with rapidly evolving viruses DOI Creative Commons
Mariam Maltseva, Alexa Keeshan, Curtis Cooper

и другие.

Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)

Опубликована: Авг. 16, 2024

Immune imprinting is a phenomenon that stems from the fundamentals of immunological memory. Upon recurrent exposures to an evolving pathogen, immune system must weigh benefits rapidly recalling established antibody repertoires with greater affinity initial variant or invest additional time and energy in producing de novo responses specific emerging variant. In this review, we delve into mechanistic complexities its role shaping subsequent responses, both recall, against respiratory viruses such as influenza coronaviruses. By exploring duality imprinting, examine potential enhance hinder protection disease, while emphasizing host viral factors. Finally, explore how different vaccine platforms may affect comment on strategies can favor variant-specific responses.

Язык: Английский

Процитировано

8