bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 11, 2024
Complex behaviors like navigation rely on sequenced motor outputs that combine to generate effective movement. The brain-wide organization of the circuits integrate sensory signals select and execute appropriate sequences is not well understood. Here, we characterize architecture neural control
Язык: Английский
Cell, Год журнала: 2024, Номер 187(10), С. 2574 - 2594.e23
Опубликована: Май 1, 2024
High-resolution electron microscopy of nervous systems has enabled the reconstruction synaptic connectomes. However, we do not know sign for each connection (i.e., whether a is excitatory or inhibitory), which implied by released transmitter. We demonstrate that artificial neural networks can predict transmitter types presynapses from micrographs: network trained to six transmitters (acetylcholine, glutamate, GABA, serotonin, dopamine, octopamine) achieves an accuracy 87% individual synapses, 94% neurons, and 91% known cell across D. melanogaster whole brain. visualize ultrastructural features used prediction, discovering subtle but significant differences between phenotypes. also analyze distributions brain find neurons develop together largely express only one fast-acting GABA). hope our publicly available predictions act as accelerant neuroscientific hypothesis generation fly.
Язык: Английский
Процитировано
114
Nature, Год журнала: 2024, Номер 626(8000), С. 808 - 818
Опубликована: Фев. 7, 2024
Neuronal signals that are relevant for spatial navigation have been described in many species
Язык: Английский
Процитировано
44
Neuron, Год журнала: 2024, Номер 112(15), С. 2581 - 2599.e23
Опубликована: Май 24, 2024
Anchoring goals to spatial representations enables flexible navigation but is challenging in novel environments when both must be acquired simultaneously. We propose a framework for how Drosophila uses internal of head direction (HD) build goal upon selective thermal reinforcement. show that flies use stochastically generated fixations and directed saccades express heading preferences an operant visual learning paradigm HD neurons are required modify these based on used symmetric setting expose flies' co-evolve the reliability interacting impacts behavior. Finally, we describe rapid new headings may rest behavioral policy whose parameters form genetically encoded circuit architecture. Such evolutionarily structured architectures, which enable rapidly adaptive behavior driven by representations, relevant across species.
Язык: Английский
Процитировано
17
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown
Опубликована: Апрель 5, 2020
Abstract Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.
Язык: Английский
Процитировано
72
Journal of Comparative Physiology A, Год журнала: 2023, Номер 209(4), С. 467 - 488
Опубликована: Янв. 20, 2023
Abstract Using odors to find food and mates is one of the most ancient highly conserved behaviors. Arthropods from flies moths crabs use broadly similar strategies navigate toward odor sources—such as integrating flow information with information, comparing concentration across sensors, over time. Because arthropods share many homologous brain structures—antennal lobes for processing olfactory mechanosensors flow, mushroom bodies (or hemi-ellipsoid bodies) associative learning, central complexes navigation, it likely that these closely related behaviors are mediated by neural circuits. However, differences in types they seek, physics dispersal, locomotion water, air, on substrates mean circuits must have adapted generate a wide diversity odor-seeking In this review, we discuss common specializations observed navigation behavior arthropods, review our current knowledge about subserving behavior. We propose comparative study arthropod nervous systems may provide insight into how set basic circuit structures has diversified different environments.
Язык: Английский
Процитировано
24
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Сен. 20, 2023
Neural processing of a desired moving direction requires the continuous comparison between current heading and goal direction. While neural basis underlying is well-studied, coding remains unclear in insects. Here, we used tetrode recordings tethered flying monarch butterflies to unravel how represented insect brain. recording, maintained robust directions relative virtual sun. By resetting their directions, found neurons whose spatial tuning was tightly linked directions. Importantly, unaffected when changed after compass perturbations, showing that these specifically encode Overall, here discovered invertebrate goal-direction share functional similarities cells reported mammals. Our results give insights into evolutionarily conserved principles goal-directed orientation animals.
Язык: Английский
Процитировано
22
Cell, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
13
Опубликована: Ноя. 27, 2024
Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.
Язык: Английский
Процитировано
13
Trends in Neurosciences, Год журнала: 2024, Номер 47(11), С. 904 - 917
Опубликована: Окт. 10, 2024
Язык: Английский
Процитировано
7
Current Opinion in Behavioral Sciences, Год журнала: 2024, Номер 57, С. 101390 - 101390
Опубликована: Апрель 9, 2024
The central complex (CX) is a highly conserved region of the insect brain, and its ubiquitous occurrence suggests that neural circuits are fundamental importance. While overall layout has not changed since evolution flight, substantial variations exist in internal organization all CX components. By changing details system repeating columns layers, these differences affect almost crystalline thus characteristic neuroarchitecture directly links structure with function. neuropil level changes suggest widespread cellular architecture circuits, data at deeper levels mostly limited to fruit fly Drosophila. Nevertheless, interspecies neuron-level have begun emerge. Whereas small compared astounding degree conservation, they reveal evolvable aspects circuitry, providing promising starting points for future research using comparative circuit-level analysis.
Язык: Английский
Процитировано
6