Molecules,
Год журнала:
2023,
Номер
28(2), С. 631 - 631
Опубликована: Янв. 7, 2023
The
gut
microbiota
has
been
confirmed
as
an
important
part
in
human
health,
and
is
even
take
‘organ’.
interaction
between
the
host
intestinal
environment
plays
a
key
role
digestion,
metabolism,
immunity,
inflammation,
diseases.
dietary
component
major
factor
that
affects
composition
function
of
microbiota.
Food
additives
have
widely
used
to
improve
color,
taste,
aroma,
texture,
nutritional
quality
processed
food.
increasing
variety
quantity
food
diets
lead
increased
frequency
dose
exposure,
especially
artificial
additives,
which
become
concern
consumers.
There
are
studies
focusing
on
impact
microbiota,
long-term
exposure
could
induce
changes
microbes,
related
health
disease.
Therefore,
aim
this
review
summarize
additives.
Nucleic Acids Research,
Год журнала:
2023,
Номер
51(W1), С. W115 - W121
Опубликована: Май 1, 2023
Carbohydrate
active
enzymes
(CAZymes)
are
made
by
various
organisms
for
complex
carbohydrate
metabolism.
Genome
mining
of
CAZymes
has
become
a
routine
data
analysis
in
(meta-)genome
projects,
owing
to
the
importance
bioenergy,
microbiome,
nutrition,
agriculture,
and
global
carbon
recycling.
In
2012,
dbCAN
was
provided
as
an
online
web
server
automated
CAZyme
annotation.
dbCAN2
(https://bcb.unl.edu/dbCAN2)
further
developed
2018
meta
combine
multiple
tools
improved
also
included
CGC-Finder,
tool
identifying
gene
clusters
(CGCs)
(meta-)genomes.
We
have
updated
dbCAN3
with
following
new
functions
components:
(i)
dbCAN-sub
profile
Hidden
Markov
Model
database
(HMMdb)
substrate
prediction
at
subfamily
level;
(ii)
searching
against
experimentally
characterized
polysaccharide
utilization
loci
(PULs)
known
glycan
substates
dbCAN-PUL
CGC
(iii)
majority
voting
method
consider
all
predicted
from
(iv)
browsing
visualization
results
on
website.
summary,
not
only
inherits
dbCAN2,
but
integrates
three
methods
prediction.
The
emergence
of
the
coronavirus
disease
2019
pandemic
has
dramatically
increased
global
prevalence
depression.
Unfortunately,
antidepressant
drugs
benefit
only
a
small
minority
patients.
Thus,
there
is
an
urgent
need
to
develop
new
interventions.
Accumulating
evidence
supports
causal
relationship
between
gut
microbiota
dysbiosis
and
To
advance
microbiota-based
diagnostics
therapeutics
depression,
comprehensive
overview
microbial
alterations
in
depression
presented
identify
effector
biomarkers.
This
procedure
generated
215
bacterial
taxa
from
humans
312
animal
models.
Compared
controls,
shows
significant
differences
β-diversity,
but
no
changes
richness
diversity.
Additionally,
species-specific
are
identified
like
Eggerthella
decreased
Acetatifactor
rodent
Moreover,
disrupted
microbiome
balance
functional
changes,
characterized
by
enrichment
pro-inflammatory
bacteria
(e.g.,
Desulfovibrio
Escherichia/Shigella)
depletion
anti-inflammatory
butyrate-producing
Bifidobacterium
Faecalibacterium)
consistently
shared
across
species.
Confounding
effects
geographical
region,
type,
intestinal
segments
also
investigated.
Ultimately,
total
178
species
subspecies
probiotics
alleviate
depressive
phenotypes.
Current
findings
provide
foundation
for
developing
advancing
microbiota-oriented
precision
medicine
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Окт. 9, 2023
Abstract
Individual
variability
in
drug
response
(IVDR)
can
be
a
major
cause
of
adverse
reactions
(ADRs)
and
prolonged
therapy,
resulting
substantial
health
economic
burden.
Despite
extensive
research
pharmacogenomics
regarding
the
impact
individual
genetic
background
on
pharmacokinetics
(PK)
pharmacodynamics
(PD),
diversity
explains
only
limited
proportion
IVDR.
The
role
gut
microbiota,
also
known
as
second
genome,
its
metabolites
modulating
therapeutic
outcomes
human
diseases
have
been
highlighted
by
recent
studies.
Consequently,
burgeoning
field
pharmacomicrobiomics
aims
to
explore
correlation
between
microbiota
variation
IVDR
or
ADRs.
This
review
presents
an
up-to-date
overview
intricate
interactions
classical
agents
for
systemic
diseases,
including
cancer,
cardiovascular
(CVDs),
endocrine
others.
We
summarise
how
directly
indirectly,
modify
absorption,
distribution,
metabolism,
excretion
(ADME)
drugs.
Conversely,
drugs
modulate
composition
function
leading
changes
microbial
metabolism
immune
response.
discuss
practical
challenges,
strategies,
opportunities
this
field,
emphasizing
critical
need
develop
innovative
approach
multi-omics,
integrate
various
data
types,
genomic
data,
well
translate
lab
into
clinical
practice.
To
sum
up,
represents
promising
avenue
address
improve
patient
outcomes,
further
is
imperative
unlock
full
potential
precision
medicine.
