Life Sciences, Год журнала: 2024, Номер 349, С. 122721 - 122721
Опубликована: Май 15, 2024
Язык: Английский
Nature, Год журнала: 2024, Номер 627(8002), С. 165 - 173
Опубликована: Фев. 7, 2024
Язык: Английский
Процитировано
82
Protein & Cell, Год журнала: 2024, Номер unknown
Опубликована: Май 11, 2024
Abstract Alzheimer’s disease (AD), the leading cause of dementia, is characterized by accumulation amyloid plaques and neurofibrillary tangles in brain. This condition casts a significant shadow on global health due to its complex multifactorial nature. In addition genetic predispositions, development AD influenced myriad risk factors, including aging, systemic inflammation, chronic conditions, lifestyle, environmental exposures. Recent advancements understanding pathophysiology are paving way for enhanced diagnostic techniques, improved assessment, potentially effective prevention strategies. These discoveries crucial quest unravel complexities AD, offering beacon hope management treatment options millions affected this debilitating disease.
Язык: Английский
Процитировано
24
Cell, Год журнала: 2024, Номер 187(18), С. 4946 - 4963.e17
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
23
Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)
Опубликована: Янв. 13, 2025
Traumatic brain injury (TBI) is characterized by high mortality and disability rates. Disease-associated microglia (DAM) are a newly discovered subtype of microglia. However, their presence function in the acute phase TBI remain unclear. Although glycolysis important for microglial differentiation, its regulatory role DAM transformation during still In this study, we investigated functions DAM-like cells mice, as well relationship between glycolysis. controlled cortical impact model was used to induce adult male wild-type (WT) C57BL/6 mice TREM2 knockout mice. Various techniques were assess effects on cells, including RT‒qPCR, immunofluorescence assays, behavioural tests, extracellular acidification rate (ECAR) Western blot analysis, cell magnetic sorting culture, glucose lactate flow cytometry. observed depended expression. impaired neurological recovery possibly due part clearing debris secreting VEGFa BDNF. Moreover, exhibited significantly increased glycolytic activity. regulated AKT‒mTOR‒HIF-1α pathway TBI. The increase partially contributed Taken together, results our study demonstrated that present might influence modulating Our provide new possible intervening
Язык: Английский
Процитировано
3
Neural Regeneration Research, Год журнала: 2024, Номер 20(2), С. 454 - 463
Опубликована: Апрель 16, 2024
Microglia are present throughout the central nervous system and vital in neural repair, nutrition, phagocytosis, immunological regulation, maintaining neuronal function. In a healthy spinal cord, microglia accountable for immune surveillance, however, when cord injury occurs, microenvironment drastically changes, leading to glial scars failed axonal regeneration. this context, vary their gene protein expression during activation, proliferation reaction injury, influencing responses both favorably unfavorably. A dynamic multifaceted response is mediated by microglia, which interact directly with neurons, astrocytes, oligodendrocytes, stem/progenitor cells. Despite clear understanding of essential nature origin, mechanisms action new functions require extensive research. This review summarizes current studies on microglial genesis, physiological function, pathological state, highlights crucial roles proposes as therapeutic target.
Язык: Английский
Процитировано
10
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 165, С. 105848 - 105848
Опубликована: Авг. 13, 2024
Microglia, as immune cells in the central nervous system, are closely related to cognitive impairment associated with type 2 diabetes (T2D). Preliminary explorations have investigated relationship between T2D-related and activation polarization of microglia. This review summarizes potential mechanisms microglial context T2D. It discusses inflammatory responses, neuronal apoptosis, amyloid-β deposition, abnormal phosphorylation Tau protein mediated by polarization, exploring connections from multiple perspectives. Additionally, this provides references for future treatment targeting microglia clinical translation.
Язык: Английский
Процитировано
9
Journal of Central Nervous System Disease, Год журнала: 2025, Номер 17
Опубликована: Янв. 3, 2025
Background The association of genetic single-nucleotide polymorphisms (SNPs) related to endothelial function, inflammation, and their outcomes remains poorly studied. Objectives To evaluate the occurrence ischemic stroke (IS) other vascular events, relationships between 19 SNPs in genes associated with function inflammation a population at high risk stroke. Design A prospective cohort study multi-center community-based sectional survey. Methods As part China National Stroke Screening Survey program, investigation was carried out southern from May 2015 January 2020. Participants 8 randomly selected. In people who were determined be stroke, examined. Over an average follow-up period 4.7 years, results these subjects monitored using longitudinal method. new IS primary outcome assessed, combination events secondary outcome. Results total, 2893 participants classified as high-risk for 2698 resulting 192 (7.1%) experiencing various outcomes. Out these, 118 individuals (4.4%) had novel IS, 24 (0.9%) suffered hemorrhagic (HS), 53 (2.0%) developed myocardial infarction (MI), 33 (1.2%) passed away. Significant variations have been found genotype distributions TLR4 rs752998, IL6R rs4845625, TNF rs3093662 among adverse compared those without. Generalized multifactor dimensionality reduction (GMDR) analysis identified substantial SNP-SNP interaction involving HABP2 rs932650, rs1927911, rs4845625 ( P = .004). genotypes 3 linked increased (OR 2.186, 95% CI: 1.247-5.426, < .001) total 2.367, 1.433-5.798, .001), according multivariate logistic regression adjusted covariates. Conclusion incidence significantly greater categorized being interacting rs1927911 independently events.
Язык: Английский
Процитировано
1
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Stroke is a global disease that seriously threatens human life. The pathological mechanisms of ischemic stroke include neuroinflammation, oxidative stress, and the destruction blood vessels at lesion site. Here, biocompatible in situ hydrogel platform was designed to target multiple pathogenic post-stroke, including anti-inflammation, anti-oxidant, promotion angiogenesis. Double-crosslinked responsive multifunctional hydrogels could quickly respond microenvironment damage site mediate delivery nitric oxide (NO) ISO-1 (inhibitor macrophage migration inhibitory factor, MIF). demonstrated good biocompatibility scavenge reactive oxygen species (ROS) inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-10 (IL-10), MIF. In mouse model, hydrogels, when situated within cerebral infarction characterized by weak acidity elevated ROS release, would release anti-inflammatory nanoparticles rapidly exert an effect. Concurrently, NO sustained facilitate angiogenesis provide neuroprotective effects. Neurological function significantly improved treated mice assessed modified neurological severity score, rotarod test, open field test. These findings indicate held promise for alleviate injury responding brain's microenvironment.
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Abstract Ischemic stroke is the most common cerebrovascular disease and leading cause of permanent disability worldwide. Recent studies have shown that development prognosis are closely related to abnormal tryptophan metabolism. Here, significant downregulation 3‐hydroxy‐kynurenamine (3‐HKA) in patients animal models identified. Supplementation with 3‐HKA improved long‐term neurological recovery, reduced infarct volume, increased ipsilateral cerebral blood flow after distal middle artery occlusion (MCAO). promoted angiogenesis, functional vessel formation, blood‐brain barrier (BBB) repair. Moreover, inhibited A1‐like (neurotoxic) astrocyte activation but A2‐like (neuroprotective) polarization. Proteomic analysis revealed AIM2 inflammasome stroke, co‐labeling indicated expression typically astrocytes at 7 14 days stroke. Consistently, co‐cultures primary mouse brain microvascular endothelial cells astrocytes, angiogenesis oxygen‐glucose deprivation (OGD). overexpression abrogated 3‐HKA‐driven vascular remodeling vitro vivo, suggesting may regulate astrocyte‐mediated by impeding activation. In conclusion, promote post‐stroke regulating A1/A2 activation, thereby improving supplementation be an efficient therapy for
Язык: Английский
Процитировано
1
Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)
Опубликована: Фев. 15, 2025
Methamphetamine (METH) use disorder (MUD) is characterized by compulsive drug-seeking behavior and substantial neurotoxicity, posing a considerable burden on individuals society. Traditionally perceived as localized central nervous system disorder, recent preclinical clinical studies have elucidated that MUD multifaceted influenced various biological systems, particularly the immune system. Emerging evidence suggests both peripheral responses play crucial role in initiation persistence of MUD. Conceptualizing it systemic process prompts significant inquiries regarding mechanisms communication between compartments. Also, whether this intercommunication could serve diagnostic biomarkers or therapeutic targets. This review begins offering an overview mechanistic pertaining to neuroimmune systems. Finally, future directions are suggested through integration innovative technologies multidimensional data promote translation basic research into interventions.
Язык: Английский
Процитировано
1