Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Май 20, 2022
Stroke
is
one
of
the
leading
causes
mortality,
and
survivors
experience
serious
neurological
motor
behavioral
deficiencies.
Following
a
cerebral
ischemic
event,
substantial
alterations
in
both
cellular
molecular
activities
occur
because
ischemia/reperfusion
injury.
Wnt
signaling
an
evolutionarily
conserved
pathway
that
has
been
manifested
to
play
key
role
embryo
development
function
maintenance
adults.
Overactivation
previously
investigated
cancer-based
research
studies.
Recently,
abnormal
activity
observed
stroke,
which
accompanied
by
massive
blood–brain
barrier
(BBB)
disruption,
neuronal
apoptosis,
neuroinflammation
within
central
nervous
system
(CNS).
Significant
therapeutic
effects
were
after
reactivating
adynamic
canonical
different
cell
types.
To
better
understand
potential
as
novel
target
for
we
reviewed
pathogenesis
stroke
types,
including
endothelial
cells,
neurons,
oligodendrocytes,
microglia.
A
comprehensive
understanding
among
cells
may
help
evaluate
its
value
strategies
based
on
activation
can
ameliorate
complications
improve
functional
rehabilitation
stroke.
Nature Reviews Gastroenterology & Hepatology,
Год журнала:
2024,
Номер
21(4), С. 222 - 247
Опубликована: Фев. 14, 2024
Crosstalk
between
gut
and
brain
has
long
been
appreciated
in
health
disease,
the
microbiota
is
a
key
player
communication
these
two
distant
organs.
Yet,
mechanisms
through
which
influences
development
function
of
gut–brain
axis
remain
largely
unknown.
Barriers
present
are
specialized
cellular
interfaces
that
maintain
strict
homeostasis
different
compartments
across
this
axis.
These
barriers
include
epithelial
barrier,
blood–brain
barrier
blood–cerebrospinal
fluid
barrier.
ideally
positioned
to
receive
communicate
microbial
signals
constituting
gateway
for
gut–microbiota–brain
communication.
In
Review,
we
focus
on
how
modulation
by
can
constitute
an
important
channel
Moreover,
malfunction
upon
alterations
composition
could
form
basis
various
conditions,
including
often
comorbid
neurological
gastrointestinal
disorders.
Thus,
should
unravelling
molecular
move
from
simplistic
framing
as
'leaky
gut'.
A
mechanistic
understanding
barriers,
especially
during
critical
windows
development,
be
aetiology
The
modulator
This
Review
provides
overview
examines
role
disease.
Preservation
of
brain
health
has
emerged
as
a
leading
public
priority
for
the
aging
world
population.
Advances
in
neurovascular
biology
have
revealed
an
intricate
relationship
among
cells,
meninges,
and
hematic
lymphatic
vasculature
(the
neurovasculome)
that
is
highly
relevant
to
maintenance
cognitive
function.
In
this
scientific
statement,
multidisciplinary
team
experts
examines
these
advances,
assesses
their
relevance
disease,
identifies
knowledge
gaps,
provides
future
directions.
Stroke,
Год журнала:
2022,
Номер
54(3), С. 873 - 881
Опубликована: Дек. 7, 2022
Endovascular
treatment
is
a
highly
effective
therapy
for
acute
ischemic
stroke
due
to
large
vessel
occlusion.
However,
in
clinical
practice,
nearly
half
of
the
patients
do
not
have
favorable
outcomes
despite
successful
recanalization
occluded
artery.
This
unfavorable
outcome
can
be
defined
as
having
clinically
ineffective
reperfusion.
The
objective
review
describe
reperfusion
after
endovascular
and
its
underlying
risk
factors
mechanisms,
including
initial
tissue
damage,
cerebral
edema,
no-reflow
phenomenon,
injury,
procedural
features,
variations
postprocedural
management.
Further
research
needed
more
accurately
identify
at
high
improve
individualized
periprocedural
management
strategies,
increase
chance
achieving
outcomes.
Annual Review of Physiology,
Год журнала:
2023,
Номер
85(1), С. 137 - 164
Опубликована: Фев. 10, 2023
Pericytes,
attached
to
the
surface
of
capillaries,
play
an
important
role
in
regulating
local
blood
flow.
Using
optogenetic
tools
and
genetically
encoded
reporters
conjunction
with
confocal
multiphoton
imaging
techniques,
3D
structure,
anatomical
organization,
physiology
pericytes
have
recently
been
subject
detailed
examination.
This
work
has
revealed
novel
functions
morphological
features
such
as
tunneling
nanotubes
brain
microtubes
heart.
Here,
we
discuss
state
our
current
understanding
roles
flow
control
heart,
where
may
differ
due
distinct
spatiotemporal
metabolic
requirements
these
tissues.
We
also
outline
concept
electro-metabolic
signaling,
a
universal
mechanistic
framework
that
links
tissue
regulation
by
vascular
smooth
muscle
cells,
capillary
K
ATP
Kir2.1
channels
primary
sensors.
Finally,
present
major
unresolved
questions
how
they
can
be
addressed.
Acta Neuropathologica,
Год журнала:
2024,
Номер
147(1)
Опубликована: Фев. 12, 2024
Abstract
Central
nervous
system
(CNS)
accumulation
of
fibrillary
deposits
made
Amyloid
β
(A
),
hyperphosphorylated
Tau
or
α
-synuclein
(
-syn),
present
either
alone
in
the
form
mixed
pathology,
characterizes
most
common
neurodegenerative
diseases
(NDDs)
as
well
aging
brain.
Compelling
evidence
supports
that
acute
neurological
disorders,
such
traumatic
brain
injury
(TBI)
and
stroke,
are
also
accompanied
by
increased
deposition
toxic
A
,
-syn
species.
While
contribution
these
pathological
proteins
to
neurodegeneration
has
been
experimentally
ascertained,
cellular
molecular
mechanisms
driving
-syn-related
damage
remain
be
fully
clarified.
In
last
few
years,
studies
have
shown
may
contribute
inducing
and/or
promoting
blood–brain
barrier
(BBB)
disruption.
These
can
affect
BBB
integrity
directly
affecting
key
components
pericytes
endothelial
cells
(ECs)
indirectly,
macrophages
activation
dysfunction.
Here,
we
summarize
critically
discuss
findings
showing
how
NDDs,
TBI
stroke.
We
highlight
need
for
a
deeper
characterization
role
dysfunction
macrophages,
ECs
improve
diagnosis
treatment
chronic
disorders.
Journal of Clinical Investigation,
Год журнала:
2024,
Номер
134(10)
Опубликована: Май 14, 2024
Cerebral
small
vessel
disease
(cSVD)
encompasses
a
heterogeneous
group
of
age-related
pathologies
that
affect
multiple
regions.
Disease
manifestations
range
from
lesions
incidentally
detected
on
neuroimaging
(white
matter
hyperintensities,
deep
infarcts,
microbleeds,
or
enlarged
perivascular
spaces)
to
severe
disability
and
cognitive
impairment.
cSVD
accounts
for
approximately
25%
ischemic
strokes
the
vast
majority
spontaneous
intracerebral
hemorrhage
is
also
most
important
vascular
contributor
dementia.
Despite
its
high
prevalence
potentially
long
therapeutic
window,
there
are
still
no
mechanism-based
treatments.
Here,
we
provide
an
overview
recent
advances
in
this
field.
We
summarize
data
highlighting
remarkable
continuum
between
monogenic
multifactorial
cSVDs
involving
NOTCH3,
HTRA1,
COL4A1/A2
genes.
Taking
vessel-centric
view,
discuss
possible
cause-and-effect
relationships
risk
factors,
structural
functional
changes,
manifestations,
underscoring
some
major
knowledge
gaps.
Although
endothelial
dysfunction
rightly
considered
central
feature
cSVD,
contributions
smooth
muscle
cells,
pericytes,
other
cells
warrant
continued
investigation.
