Activation of Wnt/Beta-Catenin Signaling Pathway as a Promising Therapeutic Candidate for Cerebral Ischemia/Reperfusion Injury DOI Creative Commons

Zhizhun Mo,

Zhongyi Zeng, Yuxiang Liu

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: May 20, 2022

Stroke is one of the leading causes mortality, and survivors experience serious neurological motor behavioral deficiencies. Following a cerebral ischemic event, substantial alterations in both cellular molecular activities occur because ischemia/reperfusion injury. Wnt signaling an evolutionarily conserved pathway that has been manifested to play key role embryo development function maintenance adults. Overactivation previously investigated cancer-based research studies. Recently, abnormal activity observed stroke, which accompanied by massive blood–brain barrier (BBB) disruption, neuronal apoptosis, neuroinflammation within central nervous system (CNS). Significant therapeutic effects were after reactivating adynamic canonical different cell types. To better understand potential as novel target for we reviewed pathogenesis stroke types, including endothelial cells, neurons, oligodendrocytes, microglia. A comprehensive understanding among cells may help evaluate its value strategies based on activation can ameliorate complications improve functional rehabilitation stroke.

Language: Английский

Neurovascular coupling: motive unknown DOI
Patrick J. Drew

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 45(11), P. 809 - 819

Published: Aug. 19, 2022

Language: Английский

Citations

96
Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis DOI Creative Commons
María R. Aburto, John F. Cryan

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(4), P. 222 - 247

Published: Feb. 14, 2024

Crosstalk between gut and brain has long been appreciated in health disease, the microbiota is a key player communication these two distant organs. Yet, mechanisms through which influences development function of gut–brain axis remain largely unknown. Barriers present are specialized cellular interfaces that maintain strict homeostasis different compartments across this axis. These barriers include epithelial barrier, blood–brain barrier blood–cerebrospinal fluid barrier. ideally positioned to receive communicate microbial signals constituting gateway for gut–microbiota–brain communication. In Review, we focus on how modulation by can constitute an important channel Moreover, malfunction upon alterations composition could form basis various conditions, including often comorbid neurological gastrointestinal disorders. Thus, should unravelling molecular move from simplistic framing as 'leaky gut'. A mechanistic understanding barriers, especially during critical windows development, be aetiology The modulator This Review provides overview examines role disease.

Language: Английский

Citations

90
The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association DOI Open Access
Costantino Iadecola, Eric E. Smith, Josef Anrather

et al.

Stroke, Journal Year: 2023, Volume and Issue: 54(6)

Published: April 3, 2023

Preservation of brain health has emerged as a leading public priority for the aging world population. Advances in neurovascular biology have revealed an intricate relationship among cells, meninges, and hematic lymphatic vasculature (the neurovasculome) that is highly relevant to maintenance cognitive function. In this scientific statement, multidisciplinary team experts examines these advances, assesses their relevance disease, identifies knowledge gaps, provides future directions.

Language: Английский

Citations

77
Angiogenesis after ischemic stroke DOI
Jie Fang, Zhi Wang, Chao‐Yu Miao

et al.

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 44(7), P. 1305 - 1321

Published: Feb. 24, 2023

Language: Английский

Citations

71
Clinically Ineffective Reperfusion After Endovascular Therapy in Acute Ischemic Stroke DOI Open Access
Ximing Nie, Xinyi Leng, Zhongrong Miao

et al.

Stroke, Journal Year: 2022, Volume and Issue: 54(3), P. 873 - 881

Published: Dec. 7, 2022

Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large vessel occlusion. However, in clinical practice, nearly half of the patients do not have favorable outcomes despite successful recanalization occluded artery. This unfavorable outcome can be defined as having clinically ineffective reperfusion. The objective review describe reperfusion after endovascular and its underlying risk factors mechanisms, including initial tissue damage, cerebral edema, no-reflow phenomenon, injury, procedural features, variations postprocedural management. Further research needed more accurately identify at high improve individualized periprocedural management strategies, increase chance achieving outcomes.

Language: Английский

Citations

70
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature DOI
Bo‐Ran Choi, Kory Johnson, Dragan Maric

et al.

Nature Immunology, Journal Year: 2023, Volume and Issue: 24(7), P. 1110 - 1123

Published: May 29, 2023

Language: Английский

Citations

50
Pericytes and the Control of Blood Flow in Brain and Heart DOI
Thomas A. Longden, Guiling Zhao, Ashwini Hariharan

et al.

Annual Review of Physiology, Journal Year: 2023, Volume and Issue: 85(1), P. 137 - 164

Published: Feb. 10, 2023

Pericytes, attached to the surface of capillaries, play an important role in regulating local blood flow. Using optogenetic tools and genetically encoded reporters conjunction with confocal multiphoton imaging techniques, 3D structure, anatomical organization, physiology pericytes have recently been subject detailed examination. This work has revealed novel functions morphological features such as tunneling nanotubes brain microtubes heart. Here, we discuss state our current understanding roles flow control heart, where may differ due distinct spatiotemporal metabolic requirements these tissues. We also outline concept electro-metabolic signaling, a universal mechanistic framework that links tissue regulation by vascular smooth muscle cells, capillary K ATP Kir2.1 channels primary sensors. Finally, present major unresolved questions how they can be addressed.

Language: Английский

Citations

46
The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders DOI Creative Commons
Ying‐Chieh Wu,

Tizibt Ashine Bogale,

Jari Koıstınaho

et al.

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 147(1)

Published: Feb. 12, 2024

Abstract Central nervous system (CNS) accumulation of fibrillary deposits made Amyloid β (A ), hyperphosphorylated Tau or α -synuclein ( -syn), present either alone in the form mixed pathology, characterizes most common neurodegenerative diseases (NDDs) as well aging brain. Compelling evidence supports that acute neurological disorders, such traumatic brain injury (TBI) and stroke, are also accompanied by increased deposition toxic A , -syn species. While contribution these pathological proteins to neurodegeneration has been experimentally ascertained, cellular molecular mechanisms driving -syn-related damage remain be fully clarified. In last few years, studies have shown may contribute inducing and/or promoting blood–brain barrier (BBB) disruption. These can affect BBB integrity directly affecting key components pericytes endothelial cells (ECs) indirectly, macrophages activation dysfunction. Here, we summarize critically discuss findings showing how NDDs, TBI stroke. We highlight need for a deeper characterization role dysfunction macrophages, ECs improve diagnosis treatment chronic disorders.

Language: Английский

Citations

28
Obesity-induced inflammation: connecting the periphery to the brain DOI
Ophélia Le Thuc, Cristina García‐Cáceres

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(7), P. 1237 - 1252

Published: July 12, 2024

Language: Английский

Citations

22
Pathophysiology of cerebral small vessel disease: a journey through recent discoveries DOI Creative Commons
Nicolas Dupré, Antoine Drieu, Anne Joutel

et al.

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(10)

Published: May 14, 2024

Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related pathologies that affect multiple regions. Disease manifestations range from lesions incidentally detected on neuroimaging (white matter hyperintensities, deep infarcts, microbleeds, or enlarged perivascular spaces) to severe disability and cognitive impairment. cSVD accounts for approximately 25% ischemic strokes the vast majority spontaneous intracerebral hemorrhage is also most important vascular contributor dementia. Despite its high prevalence potentially long therapeutic window, there are still no mechanism-based treatments. Here, we provide an overview recent advances in this field. We summarize data highlighting remarkable continuum between monogenic multifactorial cSVDs involving NOTCH3, HTRA1, COL4A1/A2 genes. Taking vessel-centric view, discuss possible cause-and-effect relationships risk factors, structural functional changes, manifestations, underscoring some major knowledge gaps. Although endothelial dysfunction rightly considered central feature cSVD, contributions smooth muscle cells, pericytes, other cells warrant continued investigation.

Language: Английский

Citations

16