Current Opinion in Neurobiology, Год журнала: 2023, Номер 79, С. 102692 - 102692
Опубликована: Фев. 17, 2023
Язык: Английский
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Окт. 14, 2023
Abstract Previous work has shown that motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains adult mice. In present study we ask whether OL production is also required for non-motor cognition, using T-maze radial-arm-maze tasks tax spatial working memory. We find maze training OLP proliferation medial prefrontal cortex (mPFC), anterior corpus callosum (genu), dorsal thalamus hippocampal formation male mice; myelin sheath stimulated genu. Genetic blockade differentiation neo-myelination Myrf conditional-knockout mice strongly impairs training-induced improvements performance. a strong positive correlation between performance individual wild type scale during training, but not with number or intensity c-Fos + neurons mPFC, underscoring important role played by lineage cognitive processing.
Язык: Английский
Процитировано
25
Pflügers Archiv - European Journal of Physiology, Год журнала: 2023, Номер 475(9), С. 1035 - 1044
Опубликована: Июль 4, 2023
Abstract In the central nervous system, oligodendrocyte precursor cells (OPCs) are recognized as progenitors responsible for generation of oligodendrocytes, which play a critical role in myelination. Extensive research has shed light on mechanisms underlying OPC proliferation and differentiation into mature myelin-forming oligodendrocytes. However, recent advances field have revealed that OPCs multiple functions beyond their progenitors, exerting control over neural circuits brain function through distinct pathways. This review aims to provide comprehensive understanding by first introducing well-established features. Subsequently, we delve emerging roles modulating both healthy diseased states. Unraveling cellular molecular influence holds great promise identifying novel therapeutic targets system diseases.
Язык: Английский
Процитировано
22
Aging and Disease, Год журнала: 2023, Номер 15(2), С. 459 - 459
Опубликована: Авг. 2, 2023
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impacts substantial number of individuals globally. Despite its widespread prevalence, there currently no cure for AD. It widely acknowledged normal synaptic function holds key role in memory, cognitive abilities, and the interneuronal transfer information. As AD advances, symptoms including impairment, decreased density, decline become increasingly noticeable. The importance glial cells formation synapses, growth neurons, brain maturation, safeguarding microenvironment central nervous system well recognized. However, during progression, overactive can cause dysfunction, neuronal death, abnormal neuroinflammation. Both neuroinflammation dysfunction are present early stages Therefore, focusing on changes glia-synapse communication could provide insights into mechanisms behind In this review, we aim to summary various cells, microglia, astrocytes, oligodendrocytes, oligodendrocyte precursor regulating dysfunction. This may offer new perspective investigating underlying
Язык: Английский
Процитировано
22
Neuron, Год журнала: 2023, Номер 111(22), С. 3604 - 3618.e11
Опубликована: Авг. 31, 2023
Язык: Английский
Процитировано
22
Translational Neurodegeneration, Год журнала: 2023, Номер 12(1)
Опубликована: Ноя. 14, 2023
Abstract Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and phagocytosis, communicating with neighboring contributing to the integrity of blood–brain barrier (BBB). However, under pathological circumstances Alzheimer’s disease (AD), brain’s microenvironment undergoes detrimental changes that significantly impact OPCs their functions. Starting OPC functions, we delve into transformation myelin-producing oligodendrocytes, intricate signaling interactions other central nervous system (CNS), fascinating process which influences function affects CNS homeostasis. Moreover, discuss essential role BBB highlight critical contribution forming CNS-protective barriers. In context AD, deterioration local brain is discussed, mainly focusing on neuroinflammation, oxidative stress, accumulation toxic proteins. The disturb delicate balance brain, impacting regenerative capacity compromising integrity. Under conditions, experience significant alterations migration proliferation, leading impaired differentiation a reduced ability produce mature oligodendrocytes. degeneration become increasingly active progressive neurodegeneration. Finally, summarize current therapeutic approaches targeting AD. Strategies revitalize senescence, modulate pathways enhance differentiation, explore potential avenues are promising alleviating AD function. conclusion, this review highlights indispensable involvement pathogenesis interplay between underscores complexity neurodegenerative diseases. Insights from studying conditions provide foundation for innovative strategies fostering Future research will advance our understanding management diseases, ultimately offering hope effective treatments improved quality life those affected by related disorders.
Язык: Английский
Процитировано
22
Frontiers in Integrative Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Фев. 19, 2024
Bioelectronic Medicine stands as an emerging field that rapidly evolves and offers distinctive clinical benefits, alongside unique challenges. It consists of the modulation nervous system by precise delivery electrical current for treatment conditions, such post-stroke movement recovery or drug-resistant disorders. The unquestionable impact is underscored successful translation to humans in last decades, long list preclinical studies. Given emergency accelerating progress new neuromodulation treatments (i.e., hypertension, autoimmune degenerative diseases), collaboration between multiple fields imperative. This work intends foster multidisciplinary bring together different provide fundamental basis underlying Medicine. In this review we will go from biophysics cell membrane, which consider inner core neuromodulation, patient care. We discuss recently discovered mechanism neurotransmission switching how it design, update on neuronal glial health disease. advances biomedical technology have facilitated collection large amounts data, thereby introducing challenges data analysis. approaches high throughput analysis, encompassing big networks, artificial intelligence, internet things. Emphasis be placed understanding electrochemical properties neural interfaces, along with integration biocompatible reliable materials compliance regulations translational applications. Preclinical validation foundational process, critical aspects animal Finally, focus point-of-care ultimate goal bioelectronic medicine. a call scientists common endeavor: accelerate decoding era therapeutic possibilities.
Язык: Английский
Процитировано
14
Cold Spring Harbor Perspectives in Biology, Год журнала: 2024, Номер 16(8), С. a041352 - a041352
Опубликована: Фев. 12, 2024
Won-Suk Chung1,4, Katherine T. Baldwin2,4 and Nicola J. Allen3,4 1Department of Biological Sciences, Korea Advanced Institute Science Technology, Yuseong-gu, Daejeon 34141, 2Department Cell Biology Physiology UNC Neuroscience Center, University North Carolina at Chapel Hill, 27599, USA 3Molecular Neurobiology Laboratory, Salk for Studies, La Jolla, California 92037, Correspondence: wonsuk.chung{at}kaist.ac.kr; ktbaldwin{at}med.unc.edu; nallen{at}salk.edu ↵4 These authors contributed equally to this work.
Язык: Английский
Процитировано
13
Developmental Cell, Год журнала: 2024, Номер 59(7), С. 853 - 868.e7
Опубликована: Фев. 14, 2024
Phagocytes remove dead and dying cells by engaging "eat-me" ligands such as phosphatidylserine (PtdSer) on the surface of apoptotic targets. However, PtdSer is obscured bulky exofacial glycocalyx, which also exposes that activate "don't-eat-me" receptors Siglecs. Clearly, unshielding juxtamembrane required for successful engulfment cells, but mechanisms underlying this process have not been described. Using human murine we find apoptosis-induced retraction weakening cytoskeleton anchors transmembrane proteins cause an inhomogeneous redistribution glycocalyx: actin-depleted blebs emerge, lacking while rest cell body retains sufficient actin to tether glycocalyx in place. Thus, can be engaged phagocytes are targeted engulfment. Therefore, with elaborate mucinous cancer "don't-come-close-to-me" barrier must removed enable clearance phagocytosis.
Язык: Английский
Процитировано
13
Nature Genetics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
1
Trends in Neurosciences, Год журнала: 2023, Номер 47(1), С. 47 - 57
Опубликована: Дек. 4, 2023
Язык: Английский
Процитировано
21