European Journal of Neurology,
Год журнала:
2024,
Номер
31(12)
Опубликована: Авг. 20, 2024
Abstract
Background
and
purpose
Peripheral
inflammation
is
probably
involved
in
the
pathogenesis
of
progressive
supranuclear
palsy
(PSP)
it
may
be
a
common
feature
with
Parkinson's
disease
(PD).
The
peripheral
immune
profile
PSP
remains
unclear,
as
well
whether
inflammatory
pathways
differ
from
those
PD.
neutrophil‐to‐lymphocyte
ratio
(NLR)
has
been
proven
to
well‐established
biomarker
systemic
inflammation.
This
study
aimed
evaluate
compared
Methods
A
cross‐sectional
was
conducted
including
patients
PD
healthy
controls
(HCs).
Leukocyte
subpopulations
NLR
were
measured
blood.
Multivariate
linear
regression
post
hoc
tests
applied.
Electronic
databases
searched
November
2023
perform
meta‐analyses
clarify
PSP.
Results
Our
cohort
included
121
PSP,
127
266
HCs.
higher
had
neutrophil
count
Whilst
lower
lymphocyte
found
HCs,
did
not
between
supported
this
profile.
Conclusions
show
an
increased
Different
pathogenic
mechanisms
are
PD,
since
altered
mainly
driven
by
neutrophils.
Understanding
neutrophils'
role
allow
for
development
targeted
therapies.
Investigative Ophthalmology & Visual Science,
Год журнала:
2025,
Номер
66(4), С. 15 - 15
Опубликована: Апрель 7, 2025
This
study
aimed
to
explore
the
relationship
between
corneal
nerve
degeneration
and
elevated
dendritic
cells
(DCs)
in
diabetic
keratopathy.
Corneas
from
healthy
mice
were
analyzed
using
single-cell
RNA
sequencing.
Corneal
density
DC
T-cell
infiltration
quantified
through
whole-mount
staining.
Freshly
isolated
mouse
trigeminal
ganglion
(TG)
neurons
co-cultured
with
immature
DCs,
mature
activated
CD8+
T
cells,
CD4+CD25-
cells.
TG
neurite
outgrowth
was
assessed
identify
potential
effector
driving
degeneration.
In
addition,
interferon-gamma
(IFN-γ)
blocking
antibodies
used
evaluate
their
effects
on
mice.
Compared
age-matched
mice,
exhibited
a
significant
reduction
sensitivity,
along
increased
of
CD4+
vitro
co-culture
experiments
revealed
that
rather
than
DCs
significantly
inhibited
outgrowth.
Among
cytokines,
IFN-γ
corneas
impaired
induced
degeneration,
whereas
IL-4
IL-17
had
no
such
effect.
Blocking
alleviated
T-cell-induced
inhibition
but
not
or
contribute
process
partially
mediated
by
IFN-γ.
European journal of medical research,
Год журнала:
2025,
Номер
30(1)
Опубликована: Апрель 15, 2025
Parkinson's
disease
(PD),
a
progressive
neurodegenerative
disease,
still
lacks
disease-modifying
treatment
strategies.
The
formation
of
Lewy
body
is
the
typical
pathological
feature
PD.
Pathological
progression
can
be
defined
by
Braak
stages.
However,
molecular
mechanism
for
this
ascending
course
α-synuclein
pathology
remains
unclear.
In
study,
weighted
gene
co-expression
network
analysis
(WGCNA)
was
used
to
screen
stage-related
signatures,
followed
functional
enrichment
analysis,
including
ontology
(GO),
Kyoto
Encyclopedia
Genes
and
Genomes
(KEGG)
Gene
Set
Enrichment
Analysis
(GSEA).
hub
genes
were
screened
through
CytoHubba
Least
Absolute
Shrinkage
Selection
Operator
(LASSO)
analysis.
immune
cell
proportion
predicted
ImmuCellAI.
Furthermore,
transcription
factors
(TFs)
miRNAs
targeting
constructed.
After
verifying
expression
level
independent
data
sets.
validated
further
analyzed
elucidate
potential
mechanism.
Total
388
associated
with
stages
out
WGCNA
KEGG
showed
that
these
involved
in
endocytosis,
HIF-1
signaling
pathway,
synaptic
vesicle
cycle,
dopaminergic
synapse,
oxytocin
etc.
Immune
infiltration
CD4
+
T
cells,
nTreg,
Th2,
Th17,
obviously
different
between
eights
stages-related
identified,
CAMK2B,
CPLX2,
GAPDH,
GRIN1,
KCNA1,
MAPK3,
MAPT,
STXBP1
cytoHubba
plugin
LASSO
three
sets,
CPLX2
finally
identified
as
most
reliable
stages-associated
This
study
revealed
signatures
PD
novel
PD,
which
provided
target
future
therapeutic
interventions
markers.
specific
remained
clarified.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Сен. 13, 2023
Angiogenic
growth
factors
(AGFs)
are
a
class
of
secreted
cytokines
related
to
angiogenesis
that
mainly
include
vascular
endothelial
(VEGFs),
stromal-derived
factor-1
(SDF-1),
platelet-derived
(PDGFs),
fibroblast
(FGFs),
transforming
factor-beta
(TGF-β)
and
angiopoietins
(ANGs).
Accumulating
evidence
indicates
the
role
AGFs
is
not
only
limited
tumor
but
also
participating
in
progression
by
other
mechanisms
go
beyond
their
angiogenic
role.
were
shown
be
upregulated
glioma
microenvironment
characterized
extensive
high
immunosuppression.
produced
stromal
cells
can
exert
an
immunomodulatory
interacting
with
immune
cells.
This
review
aims
sum
up
interactions
among
AGFs,
cancer
particular
emphasis
on
tries
provide
new
perspectives
for
understanding
in-depth
explorations
anti-glioma
therapy.
Reviews in Medical Virology,
Год журнала:
2024,
Номер
34(6)
Опубликована: Ноя. 1, 2024
Abstract
The
emergence
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2)
in
December
2019
triggered
a
swift
global
spread,
leading
to
devastating
pandemic.
Alarmingly,
approximately
one
four
individuals
diagnosed
with
disease
(COVID‐19)
experience
varying
degrees
cognitive
impairment,
raising
concerns
about
potential
increase
neurological
sequelae
cases.
Neuroinflammation
seems
be
the
key
pathophysiological
hallmark
linking
mild
COVID‐19
fatigue,
and
patients,
highlighting
interaction
between
nervous
immune
systems
following
SARS‐CoV‐2
infection.
Several
hypotheses
have
been
proposed
explain
how
virus
disrupts
physiological
pathways
trigger
inflammation
within
CNS,
potentially
neuronal
damage.
These
include
neuroinvasion,
systemic
inflammation,
disruption
lung
gut‐brain
axes,
reactivation
latent
viruses.
This
review
explores
origins
neuroinflammation
underlying
neuroimmune
cross‐talk,
important
unanswered
questions
field.
Addressing
these
fundamental
issues
could
enhance
our
understanding
virus's
impact
on
CNS
inform
strategies
mitigate
its
detrimental
effects.
European Journal of Neurology,
Год журнала:
2024,
Номер
31(12)
Опубликована: Авг. 20, 2024
Abstract
Background
and
purpose
Peripheral
inflammation
is
probably
involved
in
the
pathogenesis
of
progressive
supranuclear
palsy
(PSP)
it
may
be
a
common
feature
with
Parkinson's
disease
(PD).
The
peripheral
immune
profile
PSP
remains
unclear,
as
well
whether
inflammatory
pathways
differ
from
those
PD.
neutrophil‐to‐lymphocyte
ratio
(NLR)
has
been
proven
to
well‐established
biomarker
systemic
inflammation.
This
study
aimed
evaluate
compared
Methods
A
cross‐sectional
was
conducted
including
patients
PD
healthy
controls
(HCs).
Leukocyte
subpopulations
NLR
were
measured
blood.
Multivariate
linear
regression
post
hoc
tests
applied.
Electronic
databases
searched
November
2023
perform
meta‐analyses
clarify
PSP.
Results
Our
cohort
included
121
PSP,
127
266
HCs.
higher
had
neutrophil
count
Whilst
lower
lymphocyte
found
HCs,
did
not
between
supported
this
profile.
Conclusions
show
an
increased
Different
pathogenic
mechanisms
are
PD,
since
altered
mainly
driven
by
neutrophils.
Understanding
neutrophils'
role
allow
for
development
targeted
therapies.
