Potential of Genome Editing to Improve Aquaculture Breeding and Production

Trends in Genetics, Год журнала: 2019, Номер 35(9), С. 672 - 684

Опубликована: Июль 19, 2019

Aquaculture is the fastest growing food production sector and rapidly becoming primary source of seafood for human diets. Selective breeding programs are enabling genetic improvement traits, such as disease resistance, but progress limited by heritability trait generation interval species. New technologies, genome editing using CRISPR/Cas9 have potential to expedite sustainable in aquaculture. Genome can introduce favorable changes genome, fixing alleles at existing loci, creating de novo alleles, or introducing from other strains The high fecundity external fertilization most aquaculture species facilitate research application a scale that not possible farmed terrestrial animals.

Язык: Английский

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Role and relevance of fish cell lines in advanced in vitro research

Molecular Biology Reports, Год журнала: 2022, Номер 49(3), С. 2393 - 2411

Опубликована: Янв. 11, 2022

Cell line derived from fish has been established as a promising tool for studying many key issues of aquaculture covering growth, disease, reproduction, genetics, and biotechnology. In addition, cell lines are very useful in vitro models toxicological, pathological, immunological studies. The easier maintenance flexible temperature regimes hypoxic conditions make them preferable tools over mammalian lines. Great excitement observed establishing characterizing new representing diverse species tissue types. well-characterized authenticated utmost essential these represent cellular functions similar to vivo state an organism otherwise it would affect the reproducibility scientific research. have exhibited encouraging results several aspects research including virology, nutrition metabolism, production vaccines, transgenic production. review paper reports developed fish, their characterization, biobanking along with potential applications challenges

Язык: Английский

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Advancing genetic improvement in the omics era: status and priorities for United States aquaculture

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Фев. 17, 2025

The innovations of the "Omics Era" have ushered in significant advancements genetic improvement agriculturally important animal species through transforming genetics, genomics and breeding strategies. These were often coordinated, part, by support provided over 30 years 1993-2023 National Research Support Project 8 (NRSP8, Animal Genome Program, NAGRP) affiliate projects focused on enabling genomic discoveries livestock, poultry, aquaculture species. parallel advances demand strategic planning future research priorities. This paper, as an output from May 2023 Aquaculture Genomics, Genetics, Breeding Workshop, provides updated status resources for United States species, highlighting major achievements emerging Finfish shellfish genome omics enhance our understanding architecture heritability performance production traits. Workshop identified present aims genomics/omics to build this progress: (1) advancing reference assembly quality; (2) integrating multi-omics data analysis traits; (3) developing collection integration phenomics data; (4) creating pathways applying information across industries; (5) providing training, extension, outreach application phenome. focuses should emphasize collection, artificial intelligence, identifying causative relationships between genotypes phenotypes, establishing apply tools industries, expansion training programs next-generation workforce facilitate sciences into operations productivity, competitiveness, sustainability. collective vision with focus highlighted priorities is intended continued advancement genomics, genetics community industries. Critical challenges ahead include practical analytical frameworks beyond academic communities that require collaborative partnerships academia, government, industry. scope review encompasses use applications study aquatic animals cultivated human consumption settings throughout their life-cycle.

Язык: Английский

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Livestock 2.0 – genome editing for fitter, healthier, and more productive farmed animals

Genome biology, Год журнала: 2018, Номер 19(1)

Опубликована: Ноя. 26, 2018

The human population is growing, and as a result we need to produce more food whilst reducing the impact of farming on environment. Selective breeding genomic selection have had transformational livestock productivity, now transgenic genome-editing technologies offer exciting opportunities for production fitter, healthier more-productive livestock. Here, review recent progress in application genome editing farmed animal species discuss potential our ability food.

Язык: Английский

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Production of a breed of red sea bream Pagrus major with an increase of skeletal muscle mass and reduced body length by genome editing with CRISPR/Cas9

Aquaculture, Год журнала: 2018, Номер 495, С. 415 - 427

Опубликована: Июнь 2, 2018

Язык: Английский

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Application of Gene Editing for Climate Change in Agriculture

Frontiers in Sustainable Food Systems, Год журнала: 2021, Номер 5

Опубликована: Сен. 7, 2021

Climate change imposes a severe threat to agricultural systems, food security, and human nutrition. Meanwhile, efforts in crop livestock gene editing have been undertaken improve performance across range of traits. Many the targeted phenotypes include attributes that could be beneficial for climate adaptation. Here, we present examples emerging applications research initiatives are aimed at improvement crops response change, discuss technical limitations opportunities therein. While only few translated production thus far, numerous studies settings demonstrated potential potent address near future.

Язык: Английский

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Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

Frontiers in Endocrinology, Год журнала: 2018, Номер 9

Опубликована: Март 12, 2018

The insulin-like growth factor (IGF) binding protein (IGFBP) family has a broad range of physiological functions and fascinating evolutionary history. This review focuses on the IGFBPs teleost fishes, where genome duplication events have diversified gene repertoire, function regulation - with six core expanded into over twenty genes in some lineages. In addition to briefly summarizing current state knowledge IGFBP evolution, expression-level regulation, we highlight gaps our understanding, promising areas for future work.

Язык: Английский

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Genome editing and its applications in genetic improvement in aquaculture

Reviews in Aquaculture, Год журнала: 2021, Номер 14(1), С. 178 - 191

Опубликована: Июль 13, 2021

Abstract In the aquaculture industry, selective breeding has played an important role in increasing production significantly. To meet global growing demand for high quality proteins, it is essential to apply novel technologies accelerate facilitate increase production. Gene and genome editing technologies, including ZFNs, TALLENS Crispr/Cas9, are promising tools speed up genetic improvement. Among all approaches, CRISPR/Cas9 system faster, cheaper precise genes/genomes. Therefore, application of technology genomes species emerging rapidly. It been applied precisely edit genes identify gene functions generate preferred traits over 20 species. This review summarises their applications rapid improvement economic industry. Challenges future directions also discussed.

Язык: Английский

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Genome editing approaches to augment livestock breeding programs

Journal of Experimental Biology, Год журнала: 2020, Номер 223(Suppl_1)

Опубликована: Фев. 1, 2020

ABSTRACT The prospect of genome editing offers a number promising opportunities for livestock breeders. Firstly, these tools can be used in functional genomics to elucidate gene function, and identify causal variants underlying monogenic traits. Secondly, they precisely introduce useful genetic variation into structured breeding programs. Such may include repair defects, the inactivation undesired genes, moving alleles haplotypes between breeds absence linkage drag. Editing could also accelerate rate progress by enabling replacement germ cell lineage commercial animals with cells derived from genetically elite lines. In future, provide complement evolving approaches decrease length generation interval through vitro gametes. For adopted, it will need seamlessly integrate schemes. This likely involve introducing edits multiple avoid bottlenecks. It require different lines maintain diversity, enable cross-breeding. requirement is at odds process-based trigger event-based regulatory approach that has been proposed products several countries. harmony, researchers some countries have ability use food animals, while others not, resulting disparate access tools, ultimately potential global trade disruptions.

Язык: Английский

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Genome editing on finfish: Current status and implications for sustainability

Reviews in Aquaculture, Год журнала: 2021, Номер 13(4), С. 2344 - 2363

Опубликована: Май 26, 2021

Abstract Novel genome editing techniques allow for efficient and targeted improvement of aquaculture stock might be a solution to solve challenges related disease environmental impacts. This review has retrieved the latest research on aquacultured finfish species, exploring technological progress scope. Genome most often been used Nile tilapia ( Oreochromis niloticus Linnaeus), followed by Atlantic salmon (Salmo salar Linnaeus). More than half studies have focused developing solutions challenges, while rest can characterized as basic fish genetics/physiology or technology development. Main traits researched are reproduction development, growth, pigmentation, resistance, use trans‐GFP study omega‐3 metabolism, respectively. There is certain correlation between species identified their commercial relevance, indicating relevance present aquaculture. Reviewing geographical origin research, China in forefront (29 publications), United States (9) Norway (7). The seems not dependent regulative conditions respective countries, but merely purpose objectives technologies. Some technical barriers presented together with overcome these‐off‐target effects, ancestral duplication mosaicism F0. One contribution more sustainable aquaculture, where prominent issues that contribute minimizing impact biodiversity.

Язык: Английский

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