d-Galactose-induced accelerated aging model: an overview

Biogerontology, Год журнала: 2019, Номер 20(6), С. 763 - 782

Опубликована: Сен. 20, 2019

Язык: Английский

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Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates d-Galactose-Induced Brain Aging in Mice

Neurotherapeutics, Год журнала: 2019, Номер 16(4), С. 1269 - 1282

Опубликована: Авг. 16, 2019

Despite tremendous advances in modern medicine, effective prevention or therapeutic strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) remain limited. Currently, accumulating evidence has demonstrated that microRNAs (miRNAs) are increasingly associated with and emerging promising targets. Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, been reported to have anti-oxidant, anti-inflammatory, anti-apoptotic properties. The present study primarily focused on ameliorative effect urolithin A aging mice exploration potential mechanisms an cognitive impairment brain aging. In this study, we first tested neuroprotective using vitro H

Язык: Английский

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Neuroprotective Potential of Ellagic Acid: A Critical Review

Advances in Nutrition, Год журнала: 2021, Номер 12(4), С. 1211 - 1238

Опубликована: Янв. 19, 2021

Язык: Английский

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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Antioxidants, Год журнала: 2022, Номер 11(7), С. 1224 - 1224

Опубликована: Июнь 22, 2022

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial protective several physiological processes, excessive senescent burden has been involved various pathological conditions including aging, tissue dysfunction chronic diseases. Oxidative stress (OS) can drive due a loss balance between pro-oxidant stimuli antioxidant defences. Therefore, the identification characterization compounds capable preventing or counteracting phenotype major interest. However, despite considerable number studies, comprehensive overview main molecules OS-induced still lacking. Here, besides brief description molecular mechanisms implicated OS-mediated we review discuss role enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur nitrogen non-protein molecules, minerals, flavonoids, non-flavonoids with anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.

Язык: Английский

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The Impact of Ellagitannins and Their Metabolites through Gut Microbiome on the Gut Health and Brain Wellness within the Gut–Brain Axis

Foods, Год журнала: 2023, Номер 12(2), С. 270 - 270

Опубликована: Янв. 6, 2023

Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods, such as pomegranates, berries, and nuts. The consumption ETs has often been associated with positive effects on many pathologies, including cardiovascular diseases, neurodegenerative syndromes, cancer. Although multiple biological activities (antioxidant, anti-inflammatory, chemopreventive) have discussed for ETs, their limited bioavailability prevents reaching significant concentrations systemic circulation. Instead, urolithins, ET gut microbiota-derived metabolites, better absorbed could be the molecules responsible antioxidant anti-inflammatory or anti-tumor cell progression. In this review, we examined dietary sources, metabolism, analyzed last recent findings ellagic acid, intestinal brain activities, potential mechanisms action, connection between microbiota metabolism consequences detected gut–brain axis. current vitro, vivo, clinical studies indicate that ET-rich individual microbiomes, urolithin types modulate signaling pathways promote beneficial health effects. A understanding role these metabolites disease pathogenesis may assist prevention treatment pathologies targeting

Язык: Английский

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Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress

PLoS ONE, Год журнала: 2020, Номер 15(1), С. e0227631 - e0227631

Опубликована: Янв. 16, 2020

Currently prescribed medications for the treatment of Alzheimer’s disease (AD) that are based on acetylcholinesterase inhibition only offer symptomatic relief but do not provide protection against neurodegeneration. There appear to be an intense need development therapeutic strategies improve brain functions also prevent The oxidative stress is one main causative factors AD. Various antioxidants being investigated neurodegeneration in objective this study was investigate neuroprotective effects naringenin (NAR) AlCl3+D-gal induced AD-like symptoms animal model. Rats were orally pre-treated with NAR (50 mg/kg) two weeks and then exposed (150 mg/kg + 300 intraperitoneally week develop symptoms. standard drug, donepezil (DPZ) used as a stimulator cholinergic activity. Our results showed pre-treatment significantly protected behavioral disturbances rats. In DPZ group, rats improved cognitive neuropsychiatric completely marked histopathological alterations. However, prevented dysfunctions Results present suggest may play role enhancing cognition it can potentially considered compound management AD future.

Язык: Английский

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Ellagic Acid Alleviates Hepatic Oxidative Stress and Insulin Resistance in Diabetic Female Rats

Nutrients, Год журнала: 2018, Номер 10(5), С. 531 - 531

Опубликована: Апрель 25, 2018

Non-alcoholic fatty liver disease (NAFLD) affects more than 70% of patients with type 2 diabetes mellitus (T2DM) and has become one the most common metabolic diseases worldwide. To date, treatments specifically targeting NAFLD do not exist. Oxidative stress insulin resistance have been implicated in pathogenesis diabetes. Accordingly, goal this present study was to determine whether Ellagic acid (EA), a natural antioxidant polyphenol found berries nuts, mitigates hepatic oxidative T2DM rats, thus alleviates NAFLD. Using adult female Goto Kakizaki (GK) non-obese spontaneous model T2DM, we that EA treatment significantly lowered fasting blood glucose reduced resistance, as shown by 21.8% reduction homeostasis assessment index (HOMA-IR), while triglyceride total cholesterol levels remained unchanged. Increased lipid accumulation diabetic GK rats markedly treatment. This effect associated downregulation NADPH oxidase subunit, p47-phox, overexpression NF-E2-related factor-2 (NRF2). Moreover, able decrease expression hypoxia-inducible factor (HIF-α), transcription linked hypoxia steatosis. We further showed activated an signaling pathway liver, evidenced increased phosphorylated Akt (Ser 473). In conclusion, our results demonstrate diminishes potently suppress via mechanisms involve reductions p47-phox HIF-α, upregulation NRF2 enhancement liver. Together, these reveal improves sensitivity metabolism result its effects. implies anti-diabetic beneficial effects for complications T2DM.

Язык: Английский

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Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats

Journal of Agricultural and Food Chemistry, Год журнала: 2019, Номер 67(11), С. 3140 - 3149

Опубликована: Фев. 28, 2019

Lycium ruthenicum Murr. (LR) is a perennial shrub commonly used as nutritional food and medicine. Herein, we identified 12 anthocyanins from LR, with petunidin derivatives constituting approximately 97% of the total anthocyanin content. Furthermore, potential mechanism exerting neuroprotective effects in d-galactose (d-gal)-treated rats was explored. Behavioral results showed that relieved d-gal-induced memory disorder. Additionally, reduced receptor for advanced glycation end products (RAGE) suppressed oxidative stress caused by d-gal. Anthocyanins microgliosis astrocytosis overexpression nuclear factor kappa B (NF-κB), interleukin-1-β (IL-1β), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α). Moreover, lowered C-jun N-terminal kinase (p-JNK), caspase-3 levels, B-cell lymphoma 2-associated X protein/B-cell 2 (Bax/Bcl-2) ratio. Thus, LR attenuated disfunction, neuroinflammation, neurodegeneration d-gal, possibly through RAGE/NF-κB/JNK pathway, representing promising, safe candidate prevention therapy neurodegenerative diseases.

Язык: Английский

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The bioactivity and applications of pomegranate peel extract: A review

Journal of Food Biochemistry, Год журнала: 2022, Номер 46(7)

Опубликована: Фев. 6, 2022

Pomegranate peel (PP) is a by-product in the processing of pomegranate products, which usually discarded as waste. However, large number researches have shown that extract (PPE) rich variety phenolic substances, among ellagic acid (EA), one main active components, has significant biological activities, such anti-oxidation, anti-tumor, anti-inflammatory, neuroprotection, anti-viral, and anti-bacterial. We analyzed mechanism EA's activity, discussed its application food industry, for instance, preservation, additives, functional foods. Combined with research status PPE, we limitations development potential order to provide theoretical reference scientific basis utilization by-products. PRACTICAL APPLICATIONS: (PP), inedible part fruit, treated In recent years, researchers been committed exploring various bioactive ingredients PP benefits human health, far-reaching significance. this paper, chemical constituents polyphenols were reviewed, mainly focusing on activity (EA). reviewed applications invention patents field, including additive, foods, providing recycling reuse PP.

Язык: Английский

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D-galactose-induced liver aging model: Its underlying mechanisms and potential therapeutic interventions

Experimental Gerontology, Год журнала: 2021, Номер 150, С. 111372 - 111372

Опубликована: Апрель 24, 2021

Язык: Английский

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