Life Sciences, Год журнала: 2019, Номер 232, С. 116595 - 116595
Опубликована: Июнь 22, 2019
Язык: Английский
Food & Function, Год журнала: 2021, Номер 12(23), С. 12142 - 12158
Опубликована: Янв. 1, 2021
Aging and aging-related metabolic complications are global problems that seriously threaten public health. Taxifolin (TAX) is a novel health food has been widely proved to have variety of biological activities used in medicine. However, the delayed effect TAX on aging process not investigated. The purpose this study explore role as natural active substance brain tissue induced by D-galactose (D-Gal) determine supplementing metabolism intestinal flora bodies. model was established intraperitoneal injection D-Gal (800 mg kg-1) once per 3 days for 12 weeks, (20 40 administered daily oral gavage after 6 weeks induction with D-Gal. After testing mice an eight-arm maze, results showed treatment significantly restored spatial learning memory impairment. Moreover, long-term incited cholinergic dysfunction mice, H&E staining revealed obvious histopathological damage structural disorder hippocampus mouse tissue, while reversed these changes. Importantly, mitigated oxidative stress injury alleviating levels reactive oxygen species (ROS) malondialdehyde (MDA) increasing antioxidant enzymes. Furthermore, decreased apoptosis regulating phosphorylation phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), activating nuclear factor-erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NADH dehydrogenase quinone 1 (NQO1) maximally moderate occurred induction. In addition, 16S rDNA analysis decelerated D-gal-induced composition abundance beneficial bacteria, including Enterorhabdus, Clostridium, Bifidobacterium, Parvibacter. conclusion, demonstrated alleviated aged also confirmed improved microbes, which provides possibility prevention disorders through potential factors.
Язык: Английский
Процитировано
58
Environmental Pollution, Год журнала: 2022, Номер 302, С. 119048 - 119048
Опубликована: Фев. 24, 2022
Язык: Английский
Процитировано
42
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(18), С. 10937 - 10937
Опубликована: Сен. 19, 2022
Aging is an unavoidable biological process that leads to the decline of human function and reduction in people's quality life. Demand for anti-aging medicines has become very urgent. Many studies have shown ellagic acid (EA), a phenolic compound widely distributed dicotyledonous plants, powerful anti-inflammation antioxidant properties. Moreover, it been demonstrated EA can enhance neuronal viability, reduce defects, alleviate damage neurodegenerative diseases such as Alzheimer's disease, Parkinson's cerebral ischemia. This paper reviews biochemical functions neuroprotective effects EA, showing clinical value its application.
Язык: Английский
Процитировано
40
Frontiers in Neuroanatomy, Год журнала: 2022, Номер 16
Опубликована: Окт. 14, 2022
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual cognitive decline. Strong antioxidants that inhibit free radicals, such as polyphenols, reduce the likelihood of developing oxidative stress-related degenerative diseases AD. Naringin, flavonoid found in citrus fruit shown to be neuroprotective, damage and minimize histopathological changes caused ischemic reperfusion, enhance long-term memory AD animal models. This work aimed comprehend role naringin defense cerebellum against aluminum chloride (AlCl3)-induced rats investigating behavioral, neurochemical, immunohistochemical, molecular mechanisms underpin its possible neuroprotective effects. Twenty-four adult albino were divided into four groups (n = 6/group): (i) Control (C) received saline per oral (p.o.), (ii) Naringin(N)-received (100 mg/kg/d) p.o, (iii) AlCl3-recived AlCl3 p.o (iv) + Naringin (AlCl3 N) both for 21 days. Behavioral tests showed an increase time reach platform Morris water maze, indicating impairment AlCl3-treated group, but co-administration significant improvement. The Rotarod test demonstrated decrease muscle coordination while it was improved N group. Neurochemical analysis hippocampus revealed significantly increased lipid peroxidation stress decreased levels reduced glutathione. Administration ameliorated these neurochemical via antioxidant properties. Cerebellar immunohistochemical expression microtubule assembly (tau protein) (iNOS) A1C13-treated On other hand, autophagic marker (LC3) marked decline Western blot confirmed cerebellar findings. Collectively, findings suggested could contribute combat AlCl3-induced
Язык: Английский
Процитировано
40
DARU Journal of Pharmaceutical Sciences, Год журнала: 2019, Номер 27(2), С. 721 - 733
Опубликована: Ноя. 18, 2019
Язык: Английский
Процитировано
63
Antioxidants, Год журнала: 2020, Номер 9(5), С. 424 - 424
Опубликована: Май 14, 2020
Antioxidant dietary intervention is considered a potential strategy in delaying age-related dysfunctions. In this study of 56 days, we assessed the antioxidant effects walnut kernel (WK) and septum extract (WSE) D-galactose (D-gal)-induced aging model naturally aged rat model. Young Wistar rats, treated with D-gal (1200 mg/week), old rats received daily WK or WSE added to feed. After 8 weeks, blood, liver, brain samples were collected hematological, biochemical, oxidative stress biomarkers, histological, immunohistochemical analyses performed. Moreover, acetylcholinesterase activity was investigated homogenates. The outcomes demonstrated significant improvement cellular and/or decrease reactive oxygen species, advanced glycation end products, nitric oxide, malondialdehyde, increase glutathione after intake both models. Additionally, showed hypoglycemic effect, lowered activity. Both diets could protect neurons against induced senescence reverse pathological conditions physiological brain. Thus, supplementation can maintain liver health reduce risk diseases, as well onset processes.
Язык: Английский
Процитировано
61
Biomedicine & Pharmacotherapy, Год журнала: 2018, Номер 108, С. 1712 - 1724
Опубликована: Окт. 12, 2018
Aging is a progressive, accumulative and natural phenomenon that leads to irreversible changes in all molecules, cells, tissues organs of an organism. Previous studies have demonstrated d-galactose (DG) imitates human aging. EA has also shown many pharmacological properties including anti-inflammatory anti-oxidant activities.In the present study, we are aimed evaluate anti-aging effects (0.01-10 μM) on DG-induced aging model SH-SY5Y neuroblastoma using assessment cell proliferation, lipid peroxidation (MDA), intra-cellular reactive oxygen species (ROS), inflammation (TNF-α), total glutathione content (GSH), Beta-Galactosidase (β-GAL) advanced glycation end products (AGEs) levels. Furthermore, were examined HO-1 or PPAR-γ pathways their selective inhibitors ZnPP GW9662, respectively.The results revealed significantly increased proliferation GSH level, while decreased levels ROS, MDA, TNF-α, β-GAL AGEs following Our findings presented pre-incubation with exacerbates toxicity features measured parameters. showed (0.1 1 either GW9662 prevents protective activities TNF-α (p < 0.001 for cases). Additionally, along did not affect AGES comparison group.Although described first time at low concentrations (0.1-1 provides greater antiaging than both its high concentration (10 metformin (2.5 mM) probably through PPAR-γ/HO-1 signaling pathway, but additional deeper investigations needed show exact involving mechanisms. It could be suggestible may as agent age-related neurological disorders such Parkinson's Alzheimer's diseases.
Язык: Английский
Процитировано
59
Microorganisms, Год журнала: 2021, Номер 9(6), С. 1288 - 1288
Опубликована: Июнь 12, 2021
Eating disorders are directly or indirectly influenced by gut microbiota and innate immunity. Probiotics have been shown to regulate stimulate immunity in a variety of species. In this study, three kinds probiotics, namely, Lactobacillus plantarum, rhamnosus Clostridium butyricum, were selected for the experiment. The results showed that addition probiotics at concentration 108 colony forming unit/mL culture water significantly increased ratio pellet feed recipients survival rate mandarin fish (Siniperca chuatsi) under pellet-feed feeding. addition, reversed decrease serum lysozyme immunoglobulin M content, activity antioxidant enzymes glutathione catalase expression appetite-stimulating regulator agouti gene-related protein caused terms intestinal health, reduced abundance pathogenic bacteria Aeromonas height villi thickness foregut basement membrane general, can improve eating
Язык: Английский
Процитировано
43
Phytomedicine, Год журнала: 2021, Номер 93, С. 153772 - 153772
Опубликована: Сен. 23, 2021
Язык: Английский
Процитировано
42
Journal of Food and Drug Analysis, Год журнала: 2022, Номер 30(2), С. 172 - 184
Опубликована: Июнь 14, 2022
It was reported that protein hydrolysates or derived peptides have more functionalities than their parent protein. Most functional are identified from various food products, including plant, fish, and land-animal sources. Within a few decades, the application of protein-origin could be divided into two main categories according to applied intentions: 1) preservatives bioactive packing materials; 2) nutraceutical ingredients. According literature, applications on preservative ingredients attracted much attention. However, approach method should changed. Multi-activities, compound formulation, comprehensive evaluation, added value by-products possible strategies. Although there been great results findings in peptides, is still big gap between lab-scale practical applications. Via this narrative review current research, scientists, food/health industry, government authorities cooperate dig new material sources application.
Язык: Английский
Процитировано
30