Current Pharmaceutical Biotechnology,
Год журнала:
2023,
Номер
25(9), С. 1112 - 1123
Опубликована: Авг. 1, 2023
Abstract:
Neurodegenerative
disorders
(NDs)
are
a
group
of
progressive,
chronic,
and
disabling
that
highly
prevalent
the
incidence
is
on
constant
rise
globally.
Alzheimer’s
disease
(AD),
one
most
common
neurodegenerative
hallmarked
by
cognitive
impairment,
amyloid-β
(Aβ)
deposition,
hyperphosphorylation
tau
protein,
cholinergic
dysfunction,
mitochondrial
toxicity,
neurodegeneration.
Available
therapeutic
agents
only
provide
symptomatic
relief
their
use
limited
due
to
serious
side
effects.
Recent
research
has
recognized
flavonoids
as
potential
multi-target
biomolecules
can
reduce
pathogenesis
AD.
Naringin,
natural
citrus
flavonoid
been
traditionally
used
treat
various
NDs
including
AD,
gained
special
attention
because
exhibits
neuroprotective
effect
affecting
numerous
signaling
pathways
with
minimum
adverse
Naringin
reduces
deposition
Aβ,
oxidative
stress
burden,
activity
glutamate
receptors,
apoptosis
neuronal
cells.
Additionally,
it
expression
phosphorylated-P38/P38
NF-κB
pathway,
showing
wide
range
molecular
targets
involved
in
naringin's
action.
The
present
study
describes
possible
pharmacological
targets,
pathways,
mechanisms
naringin
neuroprotection
against
AD-like
pathology.
Based
above
pre-clinical
reports
be
concluded
could
an
alternative
agent
for
management
manifestation.
Thus,
there
strong
recommendation
perform
more
preclinical
clinical
studies
develop
novel
molecule
drug
counteract
Antioxidants,
Год журнала:
2023,
Номер
12(3), С. 663 - 663
Опубликована: Март 7, 2023
Flavonoids
are
a
biodiverse
family
of
dietary
compounds
that
have
antioxidant,
anti-inflammatory,
antiviral,
and
antibacterial
cell
protective
profiles.
They
received
considerable
attention
as
potential
therapeutic
agents
in
biomedicine
been
widely
used
traditional
complimentary
medicine
for
generations.
Such
medical
herbal
formulations
extremely
complex
mixtures
many
pharmacologically
active
provide
outcome
through
network
pharmacological
effects
complexity.
Methods
emerging
to
determine
the
components
their
targets
decipher
complexities
how
pharmacology
provides
such
effects.
The
gut
microbiome
has
important
roles
play
generation
bioactive
flavonoid
metabolites
retaining
or
exceeding
antioxidative
anti-inflammatory
properties
intact
and,
some
cases,
new
antitumor
antineurodegenerative
bioactivities.
Certain
food
items
identified
with
high
prebiotic
profiles
suggesting
neutraceutical
supplementation
may
be
beneficially
employed
preserve
healthy
population
bacterial
symbiont
species
minimize
establishment
harmful
pathogenic
organisms.
Gut
health
is
an
consideration
effecting
overall
wellbeing
linked
organ
systems.
Bioconversion
generates
can
also
transported
by
vagus
nerve
systemic
circulation
brain
populations
exert
beneficial
effect.
This
particularly
number
neurological
disorders
(autism,
bipolar
disorder,
AD,
PD)
characterized
on
moods,
resulting
depression
anxiety,
impaired
motor
function,
long-term
cognitive
decline.
Native
flavonoids
alleviation
inflammation
tissues,
however,
concerns
raised
levels
not
achieved,
thus
allowing
them
display
optimal
Dietary
manipulation
vagal
stimulation
both
yielded
responses
treatment
autism
spectrum
disorders,
depression,
establishing
route
communication
gut-brain
axis
established
disease
intervention.
While
native
known
penetrate
blood–brain
barrier,
microbiome-generated
(e.g.,
protocatechuic
acid,
urolithins,
γ-valerolactones),
which
retain
antioxidant
potency
addition
promote
mitochondrial
cerebrovascular
microcapillary
should
considered
biotherapeutic
agents.
Studies
warranted
experimentally
examine
efficacy
directly,
they
emerge
novel
options.
Heliyon,
Год журнала:
2023,
Номер
9(6), С. e17166 - e17166
Опубликована: Июнь 1, 2023
The
endothelial
cells
(ECs)
make
up
the
inner
lining
of
blood
vessels,
acting
as
a
barrier
separating
and
tissues
in
several
organs.
ECs
maintain
endothelium
integrity
by
controlling
constriction
relaxation
vasculature,
fluidity,
adhesion,
migration.
These
actions
are
efficiently
coordinated
via
an
intricate
signaling
network
connecting
receptors,
wide
range
cellular
macromolecules.
naturally
quiescent
i.e.;
they
not
stimulated
do
proliferate.
Upon
infection
or
disease,
become
activated,
this
alteration
is
pivotal
pathogenesis
spectrum
human
neurological,
cardiovascular,
diabetic,
cancerous,
viral
diseases.
Considering
central
position
that
play
disease
pathogenesis,
therapeutic
options
have
been
targeted
at
improving
integrity,
assembly,
functioning,
health.
dietary
intake
flavonoids
present
citrus
fruits
has
associated
with
reduced
risk
dysfunction.
Naringenin
(NGN)
Naringin
(NAR),
major
grapefruit,
tomatoes,
oranges
possess
anti-inflammatory,
antioxidant
properties,
cell
survival
potentials,
which
improve
health
vascular
endothelium.
In
review,
we
provide
comprehensive
summary
advances
understanding
mechanisms
through
NGN
NAR
modulate
biomarkers
dysfunction
protect
against
unresolved
inflammation,
oxidative
stress,
atherosclerosis,
angiogenesis.
We
also
perspectives
suggest
further
studies
will
help
assess
efficacy
therapeutics
Abstract
The
cerebellum
is
crucial
for
both
motor
and
nonmotor
functions.
Alzheimer's
disease
(AD),
alongside
other
dementias
such
as
vascular
dementia
(VaD),
Lewy
body
(DLB),
frontotemporal
(FTD),
well
neurodegenerative
diseases
(NDs)
like
Parkinson's
(PD),
amyotrophic
lateral
sclerosis
(ALS),
Huntington's
(HD),
spinocerebellar
ataxias
(SCA),
are
characterized
by
specific
non‐specific
neurodegenerations
in
central
nervous
system.
Previously,
the
cerebellum's
significance
these
conditions
was
underestimated.
However,
advancing
research
has
elevated
its
profile
a
critical
node
pathology.
We
comprehensively
review
existing
evidence
to
elucidate
relationship
between
aforementioned
diseases.
Our
findings
reveal
growing
of
unequivocally
establishing
link
AD,
forms
dementia,
NDs,
supported
clinical
evidence,
pathological
biochemical
profiles,
structural
functional
neuroimaging
data,
electrophysiological
findings.
By
contrasting
cerebellar
observations
with
those
from
cerebral
cortex
hippocampus,
we
highlight
distinct
role
processes.
Furthermore,
also
explore
emerging
therapeutic
potential
targeting
treatment
This
underscores
importance
diseases,
offering
new
insights
into
mechanisms
novel
strategies.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e24619 - e24619
Опубликована: Янв. 18, 2024
Naringin
is
a
natural
flavonoid
with
therapeutic
properties
found
in
citrus
fruits
and
an
active
product
from
herbal
plants.
has
become
focus
of
attention
recent
years
because
its
ability
to
actively
participate
the
body's
immune
response
maintain
integrity
barrier.
This
review
aims
elucidate
mechanism
action
efficacy
naringin
various
inflammatory
diseases
provide
valuable
reference
for
further
research
this
field.
The
provided
chemical
structure,
bioavailability,
pharmacological
properties,
pharmacokinetics
that
good
potential
diseases,
exerting
anti-inflammatory,
anti-apoptotic,
anti-oxidative
stress,
anti-ulcerative
detoxifying
effects
disease.
Moreover,
we
great
advantage
treatment
it
safe
can
even
alleviate
toxic
side
associated
some
other
drugs,
which
may
highlight
research.
Naringin,
product,
plays
significant
role
systemic
diseases'
anti-inflammatory
antioxidant
regulation
through
signaling
pathways
molecular
mechanisms.
Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 28
Опубликована: Июнь 23, 2024
Alzheimer's
disease
(AD)
is
the
most
common
neurodegenerative
disease,
which
mainly
caused
by
damage
of
structure
and
function
central
nervous
system.
At
present,
there
are
many
adverse
reactions
in
market-available
drugs,
can't
significantly
inhibit
occurrence
AD.
Therefore,
current
focus
research
to
find
safe
effective
therapeutic
drugs
improve
clinical
treatment
Oxidative
stress
bridges
different
mechanism
hypotheses
AD
plays
a
key
role
Numerous
studies
have
shown
that
natural
flavonoids
good
antioxidant
effects.
They
can
directly
or
indirectly
resist
oxidative
stress,
Aβ
aggregation
Tau
protein
hyperphosphorylation
activating
Nrf2
other
oxidation-antioxidation-related
signals,
regulating
synaptic
function-related
pathways,
promoting
mitochondrial
autophagy,
etc.,
play
neuroprotective
In
this
review,
we
summarised
inhibiting
oxidative
injury
recent
years.
Moreover,
because
shortcomings
poor
biofilm
permeability
low
bioavailability
flavonoids,
advantages
progress
nano-drug
delivery
systems
such
as
liposomes
solid
lipid
nanoparticles
were
highlighted.
We
hope
review
provides
useful
way
explore
treatments.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2215 - 2215
Опубликована: Фев. 28, 2025
The
imbalance
between
the
overproduction
of
reactive
species
and
antioxidant
mechanisms
can
result
in
astrogliosis
oxidative
stress
associated
with
neurodegeneration.
Based
on
described
activity
naturally
occurring
flavonoids,
this
study
evaluated
flavonoid
naringenin
senecioic
acid
ester
derivatives
cortical
astrocytes.
Naringenin
(S)-naringenin
were
purified
from
Citrus
paradisi,
them
7,4-O-disenecioic
naringenin,
(S)-7,4-O-disenecioic
7-O-senecioic
synthesized
tested
for
by
free-radical
scavenging
reaction
DPPH.
flavonoids'
toxicity
glutathione
(GS)
depletion
determined
rat
astrocyte
cultures;
effects
astrocytes'
reactivity
was
expression
glial
fibrillary
acidic
protein
(GFAP)
measuring
nitric
oxide
(NO)
production
astrocytes
treated
lipopolysaccharide
(LPS,
1
µg/mL/24
h).
compounds
(1-10
μM)
presented
effects,
(S)-7,4'-O-disenecioic
most
effective.
(1-100
not
toxic
to
astrocytes,
also
promoting
an
effect
increasing
GSH.
Moreover,
7-O-senecioc
mitigated
induced
LPS,
reducing
GFAP
NO
production.
These
findings
indicate
that
present
a
pharmacological
potential
as
anti-inflammatory
brain
diseases
via
modulation
response.
Antioxidants,
Год журнала:
2024,
Номер
13(1), С. 79 - 79
Опубликована: Янв. 8, 2024
Medical
therapies
to
avoid
the
progression
of
Alzheimer's
disease
(AD)
are
limited
date.
Certain
diets
have
been
associated
with
a
lower
incidence
neurodegenerative
diseases.
In
particular,
regular
intake
foods
rich
in
polyphenols,
such
as
epicatechin
(EC),
could
help
prevent
or
mitigate
AD
progression.
This
work
aims
explore
neuroprotective
effects
EC
using
different
transgenic
strains
