Pathology - Research and Practice, Год журнала: 2024, Номер 266, С. 155791 - 155791
Опубликована: Дек. 24, 2024
Язык: Английский
Pharmaceutics, Год журнала: 2023, Номер 15(1), С. 229 - 229
Опубликована: Янв. 10, 2023
Curcumin (CUR) is a polyphenol extracted from the rhizome of Curcuma longa that possesses potent anti-inflammatory and antioxidant potential. Despite CUR’s numerous beneficial effects on human health, it has limitations, such as poor absorption. Nano-based drug delivery systems have recently been applied to improve solubility bioavailability potentialize its health effects. This review investigated different CUR-based nanomedicines inflammatory immunomodulated diseases. PUBMED, EMBASE, COCHRANE, GOOGLE SCHOLAR databases were searched, Scale for Assessment Narrative Review Articles (SANRA) was used quality assessment PRISMA guidelines. Overall, 66 studies included comprising atherosclerosis, rheumatoid arthritis (RA), Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), Huntington’s (HD), bowel diseases (IBD), psoriasis, liver fibrosis, epilepsy, COVID-19. The available scientific show there are many known nanoformulations with curcumin. They can be found in nanosuspensions, nanoparticles, nanoemulsions, solid lipid particles, nanocapsules, nanospheres, liposomes. These formulations CUR effectively adjuvants several immune-mediated atheroma plaque formation, RA, dementia, AD, PD, MS, IBD, COVID-19, anti-fibrotic fibrotic disease.
Язык: Английский
Процитировано
50
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 367 - 402
Опубликована: Янв. 1, 2025
Abstract: Poor aqueous solubility and bioavailability limit the translation of new drug candidates into clinical applications. Nanocrystal formulations offer a promising approach for improving dissolution rate saturation solubility. These are applicable various routes administration, with each presenting unique opportunities challenges posed by physiological barriers. The development nanocrystal formulation requires comprehensive understanding these barriers biological environment, along strategic modulation particle size, surface properties, charge to facilitate improved target site. This review focuses on applications nanocrystals diverse administration strategies in overcoming anatomical delivery orally administered benefit from increased solubility, prolonged gastrointestinal retention, enhanced permeation. However, nanocrystals, due their small size high area, susceptible aggregation presence gastric fluids more prone enzymatic degradation compared macrocrystalline form. Although composed pure API, application excipients like stabilizers reduces improves stability, bioavailability. Some can sustained release. Emerging research include blood-brain barrier transport, intranasal delivery, stimuli responsiveness, multifunctionality, diagnostic purposes. related toxicity, scale-up, still need further attention. Overall, engineering serves as versatile platform expanding therapeutic potential insoluble drugs enabling dose reduction existing drugs, which minimize toxicity improve at lower dosages. Keywords: nanotechnology, nanosuspension, route barriers, brain oral,
Язык: Английский
Процитировано
1
Nanomaterials, Год журнала: 2022, Номер 12(18), С. 3201 - 3201
Опубликована: Сен. 15, 2022
Cancer nanotherapeutics is an important field of research which utilizes nanomaterials as approach to cancer therapy. Nano-mediated therapeutic delivery systems overcome the adverse side effects traditional treatment methods. Nanoparticles (NPs) are considered excellent tumor-targeting vehicles due their compact and variable size, large surface area, ability load several genes drugs, mediation increased payload uptake. Despite rapid development nanotechnology, there growing concern regarding possible long-term NPs on environment human health. Green chemistry using plant materials, such curcumin, a sustainable alternative conventional reduction methods confers dual reducing capping properties. Curcumin bioactive compound isolated from rhizome Curcuma longa plant, exhibits various medicinal Curcumin-capped exhibit solubility, bioavailability, indices, antitumor This review highlights potential properties economical, simple, eco-friendly curcumin-synthesized capped for localized drugs tumor microenvironment with fewer effects.
Язык: Английский
Процитировано
30
PLoS ONE, Год журнала: 2024, Номер 19(11), С. e0309795 - e0309795
Опубликована: Ноя. 14, 2024
Background The study’s primary goal is to ascertain whether there a relationship between the processed green tea methanolic extract’s (GTME) phytochemical components and its potential effectiveness against human liver cancer cells. GTME’s composition was identified using gas chromatography-mass spectrometry, capacity lower cellular proliferation cause apoptosis in HepG2 cancerous cell lines checked. Results findings of chromatogram showed that GTME included bioactive antioxidants anticancer substances. Additionally, utilizing MTT, comet assay, acridine revealed selective cytotoxic impact with significant IC 50 value (27.3 µg/ml) on cells without any harmful effects WI-38 healthy Also, compared untreated cells, extract-treated had an upsurge proportion have undergone displayed nucleus, which sign DNA damage. In addition, treated stop G1 phase sub-G1 apoptotic (37.32%) flow cytometry analysis. Furthermore, reactive oxygen species were shown be responsible for apoptosis, tested extract significantly reduced their levels Lastly, changed protein expression linked cycle arrest apoptosis. Conclusion These provided information about processes through inhibited growth HepG2. Therefore, it has as effective natural therapy treatment cancer. However, validate these findings, animal models must used vivo studies.
Язык: Английский
Процитировано
7
Biomedical Materials, Год журнала: 2024, Номер 19(5), С. 052009 - 052009
Опубликована: Авг. 27, 2024
Abstract Curcumin is a natural polyphenolic compound extracted from turmeric with antibacterial, antioxidant, antitumor, preventive and therapeutic neurological disorders variety of bioactivities, which widely used in the field food medicine. However, drawbacks curcumin such as poor aqueous solubility stability have limited practical application curcumin. To overcome these defects enhance its functional properties, various nanoscale systems (liposomes, polymer nanoparticles, protein solid lipid metal etc) been extensively employed for encapsulation delivery. Despite rapid development nanoformulations, there lack comprehensive reviews on their preparation properties. This review provides an overview construction nano-delivery systems, mechanisms action, nanocarrier methods applications nanocarriers pharmaceutical fields to provide theoretical basis technological support efficient bio-utilization, product early clinical
Язык: Английский
Процитировано
5
Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, anticancer properties. However, efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, extensive excretion. Thus, research has focused on improving delivery systems, such as, example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve and/or facilitate targeted cancer cells. promising modulating cancer-related pathways cell proliferation death, metastatic invasion, though translation patients hindered complex mechanisms. This review analyzes factors that affect PF bioavailability, evidences of vivo effects animal models mechanisms, results clinical trials, strategies enhance bioavailability. The idea need directly interact the challenged. Future aims optimize combine standard treatments, explore epigenetic effects, modulation tumor microenvironment, interactions gut microbiota. Advances personalized medicine structural modifications stability absorption could further potential. Despite challenges, remain a avenue complementary oncotherapy solutions.
Язык: Английский
Процитировано
0
European Polymer Journal, Год журнала: 2023, Номер 196, С. 112215 - 112215
Опубликована: Июнь 10, 2023
Язык: Английский
Процитировано
11
Toxicology Reports, Год журнала: 2023, Номер 11, С. 355 - 367
Опубликована: Окт. 12, 2023
Confronting the profound public health concern of alcohol-induced liver damage calls for inventive therapeutic measures. The social, economic, and clinical ramifications are extensive demand a comprehensive understanding. This thorough examination uncovers complex relationship between alcohol intake damage, with special emphasis on pivotal roles Toll-like receptor 4 (TLR4)/NF-κB p65 CYP2E1/ROS/Nrf2 signalling networks. Different consumption patterns, determined by myriad factors, have significant implications health, leading to spectrum adverse effects. TLR4/NF-κB pathway, principal regulator inflammation immune responses, significantly contributes various disease states when its balance is disrupted. Notably, TLR4/MD-2-TNF-α pathway has been linked non-alcohol related disease, while NF-κB activation associated (ALD). subunit NF-κB, primarily responsible release inflammatory cytokines, hastens progression ALD. Breakthrough insights suggest that curcumin, robust antioxidant anti-inflammatory compound sourced from turmeric, effectively disrupts pathway. heralds new approach managing damage. Initial trials support curcumin's potential, highlighting ability substantially reduce enzyme levels. narrative surrounding alcohol-related injury gradually becoming more intricate, intertwining networks such as CYP2E1/ROS/Nrf2. protective role curcumin against marks dawn treatment possibilities. However, full realisation this promising potential necessitates rigorous future research definitively understand these mechanisms establish effectiveness safety in disorders.
Язык: Английский
Процитировано
11
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106376 - 106376
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
World Journal of Methodology, Год журнала: 2023, Номер 13(3), С. 29 - 45
Опубликована: Июнь 19, 2023
The global incidence of oral cancer has steadily increased in recent years and is associated with high morbidity mortality. Oral the most common head neck region, predominantly epithelial origin (i.e. squamous cell carcinoma). treatment modalities mainly include surgery or without radiotherapy chemotherapy. Though proven effective, chemotherapy significant adverse effects possibilities tumor resistance to anticancer drugs recurrence. Thus, there an imperative need identify suitable therapies that are highly precise minimal side make effective safer. Among available adjuvant curcumin, a plant polyphenol isolated from rhizome turmeric Curcuma longa. Curcumin been demonstrated have anti-infectious, antioxidant, anti-inflammatory, anticarcinogenic properties. poor bioavailability, which overcome by its various analogues nanoformulations, such as nanoparticles, liposome complexes, micelles, phospholipid complexes. Studies shown curcumin mediated action on multiple molecular targets, including activator protein 1, kinase B (Akt), nuclear factor κ-light-chain-enhancer activated cells, mitogen-activated kinase, epidermal growth receptor (EGFR) expression, EGFR downstream signaling pathways. These targets play important roles pathogenesis, thereby making promising modality. This review aims summarize different novel formulations their role cancer.
Язык: Английский
Процитировано
9