Journal of Clinical Medicine, Год журнала: 2024, Номер 13(20), С. 6029 - 6029
Опубликована: Окт. 10, 2024
This literature review explores the association between hypertension and major neurocognitive disorders, including delirium, Alzheimer’s disease, vascular dementia, Lewy body frontotemporal which contribute significantly to global mortality morbidity. Hypertension is a potentially modifiable risk factor for cognitive decline, as it contributes progression of neurodegenerative pathologies via damage, inflammation, disruption blood–brain barrier. Despite this, effectiveness antihypertensive treatments in preventing or alleviating decline remains contentious. While some research highlights potential benefits angiotensin-converting enzyme inhibitors angiotensin receptor blockers, other studies show inconsistent results, complicated by variations definitions, diagnostic criteria confounding factors like medication adherence. Furthermore, complex bidirectional relationship disorders warrants more investigation, can exacerbate cardiovascular risks through heightened inflammatory responses compromised autonomic regulation. underscores need prospective, long-term elucidate relationships evaluate therapeutic treatments.
Язык: Английский
Процитировано
4The impact of hypertension prevention and modification on dementia burden: A systematic review of economic studies
The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер 12(1), С. 100017 - 100017
Опубликована: Янв. 1, 2025
Neurological disorders account for the largest proportion of disability-adjusted life years globally, with dementia being third leading cause. Hypertension has been identified as a priority, targetable risk factor dementia. This study aimed to systematically review economic studies that examine impact hypertension prevention and control on costs outcomes An electronic literature search was conducted using MEDLINE, EMBASE, Scopus, Web Science, EconLit, grey sources. The inclusion criteria were: 1) evaluation studies, including both full partial evaluations; 2) primary focus dementia; 3) preventing or modifying burden quality included assessed Consensus Health Economic Criteria (CHEC) list. Twelve were in final review. Four evaluations, while eight one reporting seven prevalence. Nine considered hypothetical reductions rate, three evaluated applied hypertension-related interventions. modification associated higher expectancy average age onset. Full evaluations specific interventions found these dominated (i.e. had lower quality-adjusted life-years (QALY)) status quo scenario an acceptable incremental cost-effectiveness ratio (ICER). potential reduce cost-effective way. However, further are needed determine real-world feasibility cost-effectiveness.
Язык: Английский
Процитировано
0Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
Genome-wide association studies (GWAS) have identified over 1,000 blood pressure (BP) loci and 80 for Alzheimer's disease (AD). Considering BP is an AD risk factor, identifying pleiotropy in cognitive performance measures may indicate mechanistic links between AD. scans variables-systolic (SBP), diastolic (DBP), mean arterial (MAP), pulse (PP)-and co-calibrated scores domains (executive function, language, memory) were performed using generalized linear mixed models 116,075 longitudinal from 25,726 participants of clinic-based prospective cohorts. GWAS was conducted PLACO to estimate each SNP's main effect interaction with age, their joint on pleiotropy. Effects genome-wide significant (GWS) pleiotropic SNPs cognition as direct or mediated through evaluated Mendelian randomization. Potential contribution genes top-ranked resilience assessed by comparing expression brain tissue pathologically confirmed cases without clinical symptoms. Pleiotropy GWS associations APOE 11 novel loci. In the total sample, SBP language JPH2 ( P Joint =6.09×10 -9 ) GATA3 G×Age =1.42×10 -8 ), MAP executive function PAX2 =4.22×10 LOC105371656 =1.75×10 DBP SUFU G =2.10×10 ). cohorts, found RTN4 =1.49×10 ULK2 =2.85×10 PP memory SORBS2 =2.33×10 LOC100128993 =2.81×10 observed ADAMTS3 =2.37×10 LINC02946 =3.47×10 Five influence directly, at six differentially expressed Our results provide insight into underlying mechanisms high Ongoing efforts harmonize across several cohorts will improve power discovering, replicating, generalizing
Язык: Английский
Процитировано
0Excessive Alcohol Use as a Risk Factor for Alzheimer’s Disease: Epidemiological and Preclinical Evidence
Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown, С. 211 - 242
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Evaluating the Bidirectional Causal Effects of Alzheimer’s Disease Across Multiple Conditions: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3589 - 3589
Опубликована: Апрель 10, 2025
This study systematically evaluates and meta-analyzes Mendelian randomization studies on the bidirectional causal relationship between Alzheimer’s disease (AD) systemic diseases. We searched five databases, assessed quality, extracted data. Diseases were classified using ICD-11, meta-analysis was performed with RevMan 5.4. A total of 56 identified genetic links AD susceptibility Notably, proxies for hip osteoarthritis (OR = 0.80; p 0.007) rheumatoid arthritis 0.97; 0.004) inversely associated risk, while gout 1.02; 0.049) showed a positive association. Genetic liability to depression 1.03; 0.001) elevated risk increased delirium 1.32; 0.0005). Cardiovascular traits, including coronary artery 1.07; 0.021) hypertension 4.30; 0.044), causally linked higher risk. Other conditions, such as insomnia, chronic periodontitis, migraine, certain cancers, exhibited significant correlations. Intriguingly, herpes zoster 0.87; 0.005) cataracts 0.96; 0.012) demonstrated inverse associations AD. These findings suggest potential therapeutic targets preventive strategies, emphasizing need address comorbid diseases reduce progression.
Язык: Английский
Процитировано
0Hypertension: A Continuing Public Healthcare Issue
International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 123 - 123
Опубликована: Дек. 26, 2024
Hypertension is a cardiovascular disease defined by an elevated systemic blood pressure. This devastating afflicts 30–40% of the adult population worldwide. The burden for hypertension great, and it greatly increases risk morbidity mortality. Unfortunately, there are myriad factors that result in These include genetic factors, sedentary lifestyle, obesity, salt intake, aging, stress. Although lifestyle modifications have had limited success, anti-hypertensive drugs been moderately effective lowering New approaches to control treat digital health tools compounds activate angiotensin receptor type 2 (AT2), which can promote health. Nonetheless, research on its management vital lessening significant economic this condition.
Язык: Английский
Процитировано
1The effect of depression status on osteoarthritis: A powerful two-step Mendelian randomization study
Journal of Affective Disorders, Год журнала: 2024, Номер 364, С. 49 - 56
Опубликована: Авг. 10, 2024
Язык: Английский
Процитировано
0Causal relationship between imaging-derived phenotypes and neurodegenerative diseases: a Mendelian randomization study
Mammalian Genome, Год журнала: 2024, Номер 35(4), С. 711 - 723
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
0Exploring biomarkers of Alzheimer’s disease based on multi-omics and Mendelian randomisation analysis
Annals of Human Biology, Год журнала: 2024, Номер 51(1)
Опубликована: Ноя. 7, 2024
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with no fully curative treatment.
Язык: Английский
Процитировано
0A Neuroinflammatory View of Alzheimer’s Disease
Immune system, Год журнала: 2024, Номер unknown, С. 419 - 442
Опубликована: Ноя. 8, 2024
Язык: Английский
Процитировано
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