Association of Hypertension with Different Cognitive Disorders

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6029 - 6029

Published: Oct. 10, 2024

This literature review explores the association between hypertension and major neurocognitive disorders, including delirium, Alzheimer’s disease, vascular dementia, Lewy body frontotemporal which contribute significantly to global mortality morbidity. Hypertension is a potentially modifiable risk factor for cognitive decline, as it contributes progression of neurodegenerative pathologies via damage, inflammation, disruption blood–brain barrier. Despite this, effectiveness antihypertensive treatments in preventing or alleviating decline remains contentious. While some research highlights potential benefits angiotensin-converting enzyme inhibitors angiotensin receptor blockers, other studies show inconsistent results, complicated by variations definitions, diagnostic criteria confounding factors like medication adherence. Furthermore, complex bidirectional relationship disorders warrants more investigation, can exacerbate cardiovascular risks through heightened inflammatory responses compromised autonomic regulation. underscores need prospective, long-term elucidate relationships evaluate therapeutic treatments.

Language: Английский

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The impact of hypertension prevention and modification on dementia burden: A systematic review of economic studies

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: 12(1), P. 100017 - 100017

Published: Jan. 1, 2025

Neurological disorders account for the largest proportion of disability-adjusted life years globally, with dementia being third leading cause. Hypertension has been identified as a priority, targetable risk factor dementia. This study aimed to systematically review economic studies that examine impact hypertension prevention and control on costs outcomes An electronic literature search was conducted using MEDLINE, EMBASE, Scopus, Web Science, EconLit, grey sources. The inclusion criteria were: 1) evaluation studies, including both full partial evaluations; 2) primary focus dementia; 3) preventing or modifying burden quality included assessed Consensus Health Economic Criteria (CHEC) list. Twelve were in final review. Four evaluations, while eight one reporting seven prevalence. Nine considered hypothetical reductions rate, three evaluated applied hypertension-related interventions. modification associated higher expectancy average age onset. Full evaluations specific interventions found these dominated (i.e. had lower quality-adjusted life-years (QALY)) status quo scenario an acceptable incremental cost-effectiveness ratio (ICER). potential reduce cost-effective way. However, further are needed determine real-world feasibility cost-effectiveness.

Language: Английский

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Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Genome-wide association studies (GWAS) have identified over 1,000 blood pressure (BP) loci and 80 for Alzheimer's disease (AD). Considering BP is an AD risk factor, identifying pleiotropy in cognitive performance measures may indicate mechanistic links between AD. scans variables-systolic (SBP), diastolic (DBP), mean arterial (MAP), pulse (PP)-and co-calibrated scores domains (executive function, language, memory) were performed using generalized linear mixed models 116,075 longitudinal from 25,726 participants of clinic-based prospective cohorts. GWAS was conducted PLACO to estimate each SNP's main effect interaction with age, their joint on pleiotropy. Effects genome-wide significant (GWS) pleiotropic SNPs cognition as direct or mediated through evaluated Mendelian randomization. Potential contribution genes top-ranked resilience assessed by comparing expression brain tissue pathologically confirmed cases without clinical symptoms. Pleiotropy GWS associations APOE 11 novel loci. In the total sample, SBP language JPH2 ( P Joint =6.09×10 -9 ) GATA3 G×Age =1.42×10 -8 ), MAP executive function PAX2 =4.22×10 LOC105371656 =1.75×10 DBP SUFU G =2.10×10 ). cohorts, found RTN4 =1.49×10 ULK2 =2.85×10 PP memory SORBS2 =2.33×10 LOC100128993 =2.81×10 observed ADAMTS3 =2.37×10 LINC02946 =3.47×10 Five influence directly, at six differentially expressed Our results provide insight into underlying mechanisms high Ongoing efforts harmonize across several cohorts will improve power discovering, replicating, generalizing

Language: Английский

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Excessive Alcohol Use as a Risk Factor for Alzheimer’s Disease: Epidemiological and Preclinical Evidence

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 211 - 242

Published: Jan. 1, 2025

Language: Английский

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Evaluating the Bidirectional Causal Effects of Alzheimer’s Disease Across Multiple Conditions: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3589 - 3589

Published: April 10, 2025

This study systematically evaluates and meta-analyzes Mendelian randomization studies on the bidirectional causal relationship between Alzheimer’s disease (AD) systemic diseases. We searched five databases, assessed quality, extracted data. Diseases were classified using ICD-11, meta-analysis was performed with RevMan 5.4. A total of 56 identified genetic links AD susceptibility Notably, proxies for hip osteoarthritis (OR = 0.80; p 0.007) rheumatoid arthritis 0.97; 0.004) inversely associated risk, while gout 1.02; 0.049) showed a positive association. Genetic liability to depression 1.03; 0.001) elevated risk increased delirium 1.32; 0.0005). Cardiovascular traits, including coronary artery 1.07; 0.021) hypertension 4.30; 0.044), causally linked higher risk. Other conditions, such as insomnia, chronic periodontitis, migraine, certain cancers, exhibited significant correlations. Intriguingly, herpes zoster 0.87; 0.005) cataracts 0.96; 0.012) demonstrated inverse associations AD. These findings suggest potential therapeutic targets preventive strategies, emphasizing need address comorbid diseases reduce progression.

Language: Английский

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Hypertension: A Continuing Public Healthcare Issue

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 123 - 123

Published: Dec. 26, 2024

Hypertension is a cardiovascular disease defined by an elevated systemic blood pressure. This devastating afflicts 30–40% of the adult population worldwide. The burden for hypertension great, and it greatly increases risk morbidity mortality. Unfortunately, there are myriad factors that result in These include genetic factors, sedentary lifestyle, obesity, salt intake, aging, stress. Although lifestyle modifications have had limited success, anti-hypertensive drugs been moderately effective lowering New approaches to control treat digital health tools compounds activate angiotensin receptor type 2 (AT2), which can promote health. Nonetheless, research on its management vital lessening significant economic this condition.

Language: Английский

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The effect of depression status on osteoarthritis: A powerful two-step Mendelian randomization study

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 364, P. 49 - 56

Published: Aug. 10, 2024

Language: Английский

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Causal relationship between imaging-derived phenotypes and neurodegenerative diseases: a Mendelian randomization study

Mammalian Genome, Journal Year: 2024, Volume and Issue: 35(4), P. 711 - 723

Published: Aug. 24, 2024

Language: Английский

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Exploring biomarkers of Alzheimer’s disease based on multi-omics and Mendelian randomisation analysis

Annals of Human Biology, Journal Year: 2024, Volume and Issue: 51(1)

Published: Nov. 7, 2024

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with no fully curative treatment.

Language: Английский

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A Neuroinflammatory View of Alzheimer’s Disease

Immune system, Journal Year: 2024, Volume and Issue: unknown, P. 419 - 442

Published: Nov. 8, 2024

Language: Английский

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