Non-small-cell lung cancer
Nature Reviews Disease Primers,
Год журнала:
2024,
Номер
10(1)
Опубликована: Сен. 26, 2024
Язык: Английский
Metabolomic Analysis of Nicotine‐Induced Metabolic Disruptions and Their Amelioration by Resveratrol
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(1)
Опубликована: Янв. 1, 2025
ABSTRACT
This
study
investigates
the
metabolic
disruptions
caused
by
nicotine
(NIC)
exposure,
with
a
particular
focus
on
amino
acid
and
lipid
metabolism,
evaluates
resveratrol
(RSV)
as
potential
protective
agent.
Mice
were
divided
into
four
groups:
control
(CON),
NIC‐exposed,
NIC
+
RSV‐treated,
RSV‐only.
exposure
resulted
in
significant
weight
loss,
elevated
glucose
levels,
altered
profiles,
organ
damage,
particularly
liver
kidneys.
Increased
inflammation
was
evidenced
levels
of
IL‐6
CRP.
In
contrast,
RSV
treatment
mitigated
these
effects
improving
glycemic
indices,
reducing
inflammatory
markers.
Histopathological
analysis
confirmed
reduced
tissue
damage
group
compared
to
NIC‐alone
group.
Metabolomics
using
LC‐MS/MS
revealed
dysregulation
lipid,
acid,
nucleotide
metabolism
NIC‐exposed
mice.
Fold‐change
identified
metabolites,
including
sphingomyelin
36:1;02
(
p
<
0.001),
valine
triacylglycerol
4:0–18:1
ceramide
32:1;02
0.001).
Amino
acids
such
arginine,
phenylalanine,
glutamic
tyrosine,
lysine,
well
metabolites
like
nornicotine
cotinine,
identified,
underscoring
molecular
fragmentation
findings.
partially
restored
balance,
highlighting
its
role
modulator.
underscores
therapeutic
alleviating
NIC‐induced
dysfunctions
restoring
homeostasis
inflammation.
Additionally,
it
emphasizes
importance
addressing
NIC‐related
impairments
need
for
noninvasive
biomarkers
early
disease
detection.
Язык: Английский
Smoking-induced shifts in salivary exosomal cytokines and amino acid profiles as potential early biomarkers for oral cancer
Cytokine,
Год журнала:
2025,
Номер
187, С. 156857 - 156857
Опубликована: Янв. 11, 2025
Язык: Английский
The Role of Autophagy and Cell Communication in COPD Progression: Insights from Bioinformatics and scRNA-seq
COPD Journal of Chronic Obstructive Pulmonary Disease,
Год журнала:
2025,
Номер
22(1)
Опубликована: Фев. 24, 2025
Chronic
obstructive
pulmonary
disease
(COPD)
is
characterized
by
restricted
airflow
that
leads
to
significant
respiratory
difficulties.
This
progressive
often
results
in
diminished
function
and
the
onset
of
additional
conditions.
Autophagy,
a
critical
cellular
homeostasis
mechanism,
plays
role
exacerbation
COPD.
In
this
study,
we
utilized
various
bioinformatics
tools
identify
autophagy-related
genes
activated
smoking
individuals
with
Furthermore,
explored
immune
landscape
COPD
through
these
genes,
analyzing
cell
communication
patterns
using
scRNA-seq
data.
analysis
focused
on
key
pathways
between
epithelial
cells
other
subpopulations
different
autophagy
scores,
essential
for
understanding
initiation
progression
Язык: Английский