The Role of Autophagy and Cell Communication in COPD Progression: Insights from Bioinformatics and scRNA-seq DOI Creative Commons
Ke Ren, Lu Zou, Jingjing Yang

et al.

COPD Journal of Chronic Obstructive Pulmonary Disease, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 24, 2025

Chronic obstructive pulmonary disease (COPD) is characterized by restricted airflow that leads to significant respiratory difficulties. This progressive often results in diminished function and the onset of additional conditions. Autophagy, a critical cellular homeostasis mechanism, plays role exacerbation COPD. In this study, we utilized various bioinformatics tools identify autophagy-related genes activated smoking individuals with Furthermore, explored immune landscape COPD through these genes, analyzing cell communication patterns using scRNA-seq data. analysis focused on key pathways between epithelial cells other subpopulations different autophagy scores, essential for understanding initiation progression

Language: Английский

Non-small-cell lung cancer DOI
Lizza Hendriks, Jordi Remón, C. Faivre‐Finn

et al.

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 26, 2024

Language: Английский

Citations

43
Metabolomic Analysis of Nicotine‐Induced Metabolic Disruptions and Their Amelioration by Resveratrol DOI Open Access

Hajra Iqbal,

Kainat Ilyas,

Kanwal Rehman

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(1)

Published: Jan. 1, 2025

ABSTRACT This study investigates the metabolic disruptions caused by nicotine (NIC) exposure, with a particular focus on amino acid and lipid metabolism, evaluates resveratrol (RSV) as potential protective agent. Mice were divided into four groups: control (CON), NIC‐exposed, NIC + RSV‐treated, RSV‐only. exposure resulted in significant weight loss, elevated glucose levels, altered profiles, organ damage, particularly liver kidneys. Increased inflammation was evidenced levels of IL‐6 CRP. In contrast, RSV treatment mitigated these effects improving glycemic indices, reducing inflammatory markers. Histopathological analysis confirmed reduced tissue damage group compared to NIC‐alone group. Metabolomics using LC‐MS/MS revealed dysregulation lipid, acid, nucleotide metabolism NIC‐exposed mice. Fold‐change identified metabolites, including sphingomyelin 36:1;02 ( p < 0.001), valine triacylglycerol 4:0–18:1 ceramide 32:1;02 0.001). Amino acids such arginine, phenylalanine, glutamic tyrosine, lysine, well metabolites like nornicotine cotinine, identified, underscoring molecular fragmentation findings. partially restored balance, highlighting its role modulator. underscores therapeutic alleviating NIC‐induced dysfunctions restoring homeostasis inflammation. Additionally, it emphasizes importance addressing NIC‐related impairments need for noninvasive biomarkers early disease detection.

Language: Английский

Citations

0
Smoking-induced shifts in salivary exosomal cytokines and amino acid profiles as potential early biomarkers for oral cancer DOI
Afsareen Bano,

Ravina Vats,

Pooja Yadav

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 187, P. 156857 - 156857

Published: Jan. 11, 2025

Language: Английский

Citations

0
The Role of Autophagy and Cell Communication in COPD Progression: Insights from Bioinformatics and scRNA-seq DOI Creative Commons
Ke Ren, Lu Zou, Jingjing Yang

et al.

COPD Journal of Chronic Obstructive Pulmonary Disease, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 24, 2025

Chronic obstructive pulmonary disease (COPD) is characterized by restricted airflow that leads to significant respiratory difficulties. This progressive often results in diminished function and the onset of additional conditions. Autophagy, a critical cellular homeostasis mechanism, plays role exacerbation COPD. In this study, we utilized various bioinformatics tools identify autophagy-related genes activated smoking individuals with Furthermore, explored immune landscape COPD through these genes, analyzing cell communication patterns using scRNA-seq data. analysis focused on key pathways between epithelial cells other subpopulations different autophagy scores, essential for understanding initiation progression

Language: Английский

Citations

0