Brain-wide neural activity underlying memory-guided movement

Cell, Год журнала: 2024, Номер 187(3), С. 676 - 691.e16

Опубликована: Фев. 1, 2024

Behavior relies on activity in structured neural circuits that are distributed across the brain, but most experiments probe neurons a single area at time. Using multiple Neuropixels probes, we recorded from multi-regional loops connected to anterior lateral motor cortex (ALM), circuit node mediating memory-guided directional licking. Neurons encoding sensory stimuli, choices, and actions were brain. However, choice coding was concentrated ALM subcortical areas receiving input an ALM-dependent manner. Diverse orofacial movements encoded hindbrain; midbrain; and, lesser extent, forebrain. Choice signals first detected midbrain, followed by thalamus other brain areas. At movement initiation, choice-selective collapsed new patterns driving specific actions. Our provide foundation for models of decision-making initiation.

Язык: Английский

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The Superior Colliculus: Cell Types, Connectivity, and Behavior

Neuroscience Bulletin, Год журнала: 2022, Номер 38(12), С. 1519 - 1540

Опубликована: Апрель 28, 2022

Abstract The superior colliculus (SC), one of the most well-characterized midbrain sensorimotor structures where visual, auditory, and somatosensory information are integrated to initiate motor commands, is highly conserved across vertebrate evolution. Moreover, cell-type-specific SC neurons integrate afferent signals within local networks generate defined output related innate cognitive behaviors. This review focuses on recent progress in understanding phenotypic diversity amongst their intrinsic circuits long-projection targets. We further describe relevant neural specific cell types relation behavioral outputs functions. systematic delineation organization, types, connections put into context species as these depend upon laminar architecture. we focus circuitry involving saccadic eye movement, Overall, provides insight functioning represents a basis for pathology associated with dysfunction.

Язык: Английский

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Red Light Optogenetics in Neuroscience

Frontiers in Cellular Neuroscience, Год журнала: 2022, Номер 15

Опубликована: Янв. 3, 2022

Optogenetics, a field concentrating on controlling cellular functions by means of light-activated proteins, has shown tremendous potential in neuroscience. It possesses superior spatiotemporal resolution compared to the surgical, electrical, and pharmacological methods traditionally used studying brain function. A multitude optogenetic tools for neuroscience have been created that, example, enable control action generation via ion channels. Other proteins brain, long-term potentiation or ablate specific subtypes neurons. In vivo applications, however, majority are operated with blue, green, yellow light, which all limited penetration biological tissues red light especially infrared light. This difference is significant, considering size rodent major research model Our review will focus utilization light-operated We first outline advantages studies. Then we provide brief overview systems new developments field. Finally, highlight different further facilitate use optogenetics

Язык: Английский

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Functional Organisation of the Mouse Superior Colliculus

Frontiers in Neural Circuits, Год журнала: 2022, Номер 16

Опубликована: Апрель 29, 2022

The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that widely implicated in organisation and control behaviour. SC receives input from large number brain areas, provides outputs to areas. convergence divergence anatomical connections with different areas systems challenges for understanding how contributes Recent work mouse has provided datasets, wealth new data experiments identify manipulate cells within SC, their inputs outputs, during simple behaviours. These offer an opportunity better understand roles plays these However, some observations appear, at first sight, be contradictory. Here we review this recent hypothesise framework which can capture observations, requires only small change previous models. Specifically, functional explained by supposing three largely distinct circuits support classes behaviours–arrest, turning towards, triggering escape or capture. behaviours are hypothesised supported optic, intermediate deep layers, respectively.

Язык: Английский

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Optogenetic activation of the inhibitory nigro-collicular circuit evokes contralateral orienting movements in mice

Cell Reports, Год журнала: 2022, Номер 39(3), С. 110699 - 110699

Опубликована: Апрель 1, 2022

We report that increasing inhibition from the basal ganglia (BG) to superior colliculus (SC) through substantia nigra pars reticulata (nigra) using in vivo optogenetic activation of GABAergic terminals mice produces contralateral orienting movements. These movements are unexpected because decreases, and not increases, nigral activity generally associated with initiation found that, slice recordings, same stimulation producing evokes post-inhibitory rebound depolarization followed by Na+ spikes SC output neurons. Moreover, blocking T-type Ca2+ channels slices prevent subsequent spiking neurons also reduce likelihood vivo. On basis these results, we propose addition permissive role, BG may play an active role generation driving

Язык: Английский

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Genetically defined neuron types underlying visuomotor transformation in the superior colliculus

Nature reviews. Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Язык: Английский

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Neuronal modulation in the mouse superior colliculus during covert visual selective attention

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Фев. 15, 2022

Abstract Covert visual attention is accomplished by a cascade of mechanisms distributed across multiple brain regions. Visual cortex associated with enhanced representations relevant stimulus features, whereas the contributions subcortical circuits are less well understood but have been selection spatial locations and suppression distracting stimuli. As step toward understanding these circuits, here we identified how neuronal activity in intermediate layers superior colliculus (SC) head-fixed mice modulated during covert attention. We found that cues both firing rate spike-count correlations. Crucially, cue-related modulation was due to enhancement at cued location rather than uncued location, indicating SC neurons our task were an excitatory or disinhibitory circuit mechanism focused on broad inhibition irrelevant locations. This improved discriminability visual-change-evoked activity, only when assessed for between contralateral ipsilateral SC. Together, findings indicate mouse can contribute selective biasing processing favor expected contain task-relevant information.

Язык: Английский

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Superior colliculus bidirectionally modulates choice activity in frontal cortex

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Ноя. 14, 2023

Abstract Action selection occurs through competition between potential choice options. Neural correlates of are observed across frontal cortex and downstream superior colliculus (SC) during decision-making, yet how these regions interact to mediate remains unresolved. Here we report that SC can bidirectionally modulate drive activity in cortex. In the mouse, topographically matched formed a descending motor pathway for directional licking re-entrant loop via thalamus. During distinct neuronal populations both encoded opposing lick directions exhibited competitive interactions. GABAergic neurons ipsilateral locally inhibited glutamatergic contralateral choice. Activating or suppressing cell types could These results thus identify as major locus within broader action network.

Язык: Английский

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Involvement of superior colliculus in complex figure detection of mice

eLife, Год журнала: 2024, Номер 13

Опубликована: Янв. 25, 2024

Object detection is an essential function of the visual system. Although cortex plays important role in object detection, superior colliculus can support when ablated or silenced. Moreover, it has been shown that superficial layers mouse SC (sSC) encode features complex objects, and this code not inherited from primary cortex. This suggests sSC may provide a significant contribution to vision. Here, we use optogenetics show involved figure based on differences contrast, orientation, phase. Additionally, our neural recordings sSC, image elements belong elicit stronger activity than those same they are part background. The discriminability higher for correct trials incorrect trials. Our results new insight into behavioral relevance processing takes place sSC.

Язык: Английский

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Neural mechanisms for the localization of unexpected external motion

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 30, 2023

To localize objects during active sensing, animals must differentiate stimuli caused by volitional movement from real-world object motion. determine a neural basis for this ability, we examined the mouse superior colliculus (SC), which contains multiple egocentric maps of sensorimotor space. By placing mice in whisker-guided virtual reality, discovered rapidly adapting tactile response that transiently emerged externally generated gains whisker contact. Responses to self-generated touch matched history were significantly attenuated, revealing transient magnitude is controlled predictions. The gradually decreased with repetitions external motion, slow habituation based on history. direction motion was accurately encoded firing rates responsive neurons. These data reveal whisker-specific adaptation and predictions SC neurons enhance localization unexpected, changes

Язык: Английский

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