Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

Nature Medicine, Год журнала: 2019, Номер 25(7), С. 1096 - 1103

Опубликована: Июль 1, 2019

Язык: Английский

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The gut microbiome as a modulator of healthy ageing

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2022, Номер 19(9), С. 565 - 584

Опубликована: Апрель 25, 2022

Язык: Английский

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How Probiotics Affect the Microbiota

Frontiers in Cellular and Infection Microbiology, Год журнала: 2020, Номер 9

Опубликована: Янв. 15, 2020

Probiotics have been used to treat a variety of diseases for decades: however, what is the rationale under this? Such treatment was first proposed in early 19th century based on observations decreased Bifidobacteria populations children suffering diarrhea, suggesting that oral intake could replete microbiota subpopulation and improve health. Since then, studies shown modifications gut or skin course suggested positive effects certain probiotics. Most failed report any impact microbiota. The probiotics, as well bacteria colonizing food, does not reside their ability graft but rather sharing genes metabolites, supporting challenged microbiota, by direct influence epithelial immune cells. argue probiotics be associated conventional drugs insulin resistance, infectious diseases, inflammatory psychiatric disorders also interfere with drug metabolism. Nevertheless, context plethora probiotic strains associations, produced such conditions do allow comparisons, it remains difficult know whether patient would benefit from taking particular probiotic. In other words, although several mechanisms are observed when studying single strain, all individual expected share same effects. order clarify role clinics, we explore here relation between

Язык: Английский

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Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

Cell, Год журнала: 2020, Номер 181(6), С. 1263 - 1275.e16

Опубликована: Май 20, 2020

Язык: Английский

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Gut microbiota in obesity

World Journal of Gastroenterology, Год журнала: 2021, Номер 27(25), С. 3837 - 3850

Опубликована: Июль 5, 2021

Obesity is a major global health problem determined by heredity and environment, its incidence increasing yearly. In recent years, evidence linking obesity to the gut microbiota has been reported. Gut management become new method of treatment. However, complex interactions among genetics, microbiota, remain poorly understood. this review, we summarize characteristics in obesity, mechanism induced influence genetic environmental factors on provide support for understanding relationship between microbiota. At same time, prospect research related proposed.

Язык: Английский

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Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

Molecular and Cellular Endocrinology, Год журнала: 2022, Номер 546, С. 111572 - 111572

Опубликована: Янв. 20, 2022

The role of the intestinal microbiota as a regulator gut-brain axis signalling has risen to prominence in recent years. Understanding relationship between gut microbiota, metabolites it produces, and brain will be critical for subsequent development new therapeutic approaches, including identification novel psychobiotics. A key focus this regard have been short-chain fatty acids (SCFAs) produced by bacterial fermentation dietary fibre, which include butyrate, acetate, propionate. Ongoing research is focused on entry SCFAs into systemic circulation from lumen, their migration cerebral across blood barrier, potential exert acute chronic effects structure function. This review aims discuss our current mechanistic understanding direct indirect influence that function, behaviour physiology, inform future microbiota-targeted interventions disorders.

Язык: Английский

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Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Окт. 6, 2020

Abstract Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering microbiota like oral intake of probiotics or berberine (BBR), bacteriostatic agent, merit metabolic homoeostasis. We hence conducted randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patients from 20 centres in China. Four-hundred-nine eligible participants were enroled, randomly assigned (1:1:1:1) and completed 12-week treatment either BBR-alone, probiotics+BBR, probiotics-alone, placebo, after one-week run-in gentamycin pretreatment. The changes glycated haemoglobin, as the primary outcome, probiotics+BBR (least-squares mean [95% CI], −1.04[−1.19, −0.89]%) BBR-alone group (−0.99[−1.16, −0.83]%) significantly greater than that placebo probiotics-alone groups (−0.59[−0.75, −0.44]%, −0.53[−0.68, −0.37]%, P < 0.001). BBR induced more gastrointestinal side effects. Further metagenomics metabolomic studies found hypoglycaemic effect mediated by inhibition DCA biotransformation Ruminococcus bromii . Therefore, our study reports human microbial related mechanism underlying antidiabetic on T2D. (Clinicaltrial.gov Identifier: NCT02861261).

Язык: Английский

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Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives

Aging and Disease, Год журнала: 2022, Номер 13(4), С. 1106 - 1106

Опубликована: Янв. 1, 2022

Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides crucial signaling metabolites for the physiological hosts. In healthy state, gut microbiota are helpful maintaining basic functions hosts, whereas disturbed production these can lead to numerous diseases such as metabolic diseases, cardiovascular neurodegenerative and cancer. Although there many reviews about specific mechanisms on is no comprehensive summarization metabolites. this Opinion, we discuss knowledge including types their ways acting targets. addition, summarize pathologic in health shaping composition nutrition. This paper be understanding roles thus provide guidance developing suitable therapeutic strategies combat microbial-driven improve health.

Язык: Английский

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The Two-Way Polyphenols-Microbiota Interactions and Their Effects on Obesity and Related Metabolic Diseases

Frontiers in Nutrition, Год журнала: 2019, Номер 6

Опубликована: Дек. 20, 2019

Metabolic diseases can change the gut microbiota composition and function, pathogenic bacteria contribute to development of metabolic disorders. Polyphenols may act in favor increase beneficial hamper bacteria. In addition, on polyphenols their bioavailability. This two-way interaction between could affect human metabolism reduce cardiometabolic risk. Despite possible benefits for health through modulating microbiome, studies are scarce present several limitations. review provides an overview polyphenol–microbiota its effects

Язык: Английский

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Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2019, Номер 20(4), С. 439 - 447

Опубликована: Окт. 25, 2019

Abstract There is now a wealth of evidence showing that communication between microbiota and the host critical to sustain vital functions healthy host, disruptions this homeostatic coexistence are known be associated with range diseases including obesity type 2 diabetes. Microbiota-derived metabolites act both as nutrients messenger molecules can signal distant organs in body shape pathophysiology. In review, we provide new perspective on succinate gut microbiota-derived metabolite key role governing intestinal homeostasis energy metabolism. Thus, not merely major intermediary TCA traditionally considered an extracellular danger but also by-product some bacteria primary cross-feeding resident microbes. addition maintain microbiome, specific peripheral tissues regulating nutrient metabolism should rule out. Indeed, recent research point probiotic interventions directed modulate levels lumen, microbiota-based therapies treat related co-morbidities. While further essential, large strategic mediator microbiota-host cross-talk, which might basis for therapeutically approaches near future.

Язык: Английский

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