Hallmarks of aging: An expanding universe

Cell, Год журнала: 2023, Номер 186(2), С. 243 - 278

Опубликована: Янв. 1, 2023

Язык: Английский

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The gut microbiome as a modulator of healthy ageing

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2022, Номер 19(9), С. 565 - 584

Опубликована: Апрель 25, 2022

Язык: Английский

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Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

Molecular and Cellular Endocrinology, Год журнала: 2022, Номер 546, С. 111572 - 111572

Опубликована: Янв. 20, 2022

The role of the intestinal microbiota as a regulator gut-brain axis signalling has risen to prominence in recent years. Understanding relationship between gut microbiota, metabolites it produces, and brain will be critical for subsequent development new therapeutic approaches, including identification novel psychobiotics. A key focus this regard have been short-chain fatty acids (SCFAs) produced by bacterial fermentation dietary fibre, which include butyrate, acetate, propionate. Ongoing research is focused on entry SCFAs into systemic circulation from lumen, their migration cerebral across blood barrier, potential exert acute chronic effects structure function. This review aims discuss our current mechanistic understanding direct indirect influence that function, behaviour physiology, inform future microbiota-targeted interventions disorders.

Язык: Английский

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Meta-hallmarks of aging and cancer

Cell Metabolism, Год журнала: 2023, Номер 35(1), С. 12 - 35

Опубликована: Янв. 1, 2023

Язык: Английский

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The landscape of aging

Science China Life Sciences, Год журнала: 2022, Номер 65(12), С. 2354 - 2454

Опубликована: Сен. 2, 2022

Язык: Английский

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Язык: Английский

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Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Microbiome, Год журнала: 2022, Номер 10(1)

Опубликована: Апрель 29, 2022

Altered intestinal microbiota composition in later life is associated with inflammaging, declining tissue function, and increased susceptibility to age-associated chronic diseases, including neurodegenerative dementias. Here, we tested the hypothesis that manipulating influences development of major comorbidities aging and, particular, inflammation affecting brain retina.

Язык: Английский

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Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease

Molecular Neurodegeneration, Год журнала: 2022, Номер 17(1)

Опубликована: Март 5, 2022

The implication of gut microbiota in the control brain functions health and disease is a novel, currently emerging concept. Accumulating data suggest that exert its action at least part by modulating neuroinflammation. Given link between neuroinflammatory changes neuronal activity, it plausible may affect indirectly impacting microglia, key player Indeed, increasing evidence suggests interplay microglia synaptic dysfunction involve microbiota, among other factors. In addition to these indirect microglia-dependent actions on has been recently recognized could also activity directly stimulation vagus nerve.

Язык: Английский

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Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine

Nature Neuroscience, Год журнала: 2022, Номер 25(3), С. 295 - 305

Опубликована: Март 1, 2022

Язык: Английский

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The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

Cellular and Molecular Life Sciences, Год журнала: 2022, Номер 79(2)

Опубликована: Янв. 19, 2022

Abstract The gut and brain link via various metabolic signalling pathways, each with the potential to influence mental, cognitive health. Over past decade, involvement of microbiota in gut–brain communication has become focus increased scientific interest, establishing microbiota–gut–brain axis as a field research. There is growing number association studies exploring microbiota’s possible role memory, learning, anxiety, stress, neurodevelopmental neurodegenerative disorders. Consequently, attention now turning how can target nutritional therapeutic strategies for improved health well-being. However, while such that function are currently under development varying levels success, still very little yet known about triggers mechanisms underlying apparent on or most evidence comes from pre-clinical rather than well controlled clinical trials/investigations. Filling knowledge gaps requires standardised methodology human studies, including strong guidance specific areas axis, need more extensive biological sample analyses, identification relevant biomarkers. Other urgent requirements new advanced models vitro vivo mechanisms, greater omics technologies supporting bioinformatics resources (training, tools) efficiently translate study findings, targets populations. key building validated base rely increasing sharing multi-disciplinary collaborations, along continued public–private funding support. This will allow research move its next phase so we identify realistic opportunities modulate better

Язык: Английский

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