Aging and Disease,
Год журнала:
2024,
Номер
15(1), С. 74 - 74
Опубликована: Янв. 1, 2024
Amyotrophic
Lateral
Sclerosis
(ALS)
is
a
devastating
neurodegenerative
disease
which
strongly
associated
with
age.
The
incidence
of
ALS
increases
from
the
age
40
and
peaks
between
ages
65
70.
Most
patients
die
respiratory
muscle
paralysis
or
lung
infections
within
three
to
five
years
appearance
symptoms,
dealing
huge
blow
their
families.
With
aging
populations,
improved
diagnostic
methods
changes
in
reporting
criteria,
likely
show
an
upward
trend
coming
decades.
Despite
extensive
researches
have
been
done,
cause
pathogenesis
remains
unclear.
In
recent
decades,
large
quantities
studies
focusing
on
gut
microbiota
shown
that
its
metabolites
seem
change
evolvement
through
brain-gut-microbiota
axis,
turn,
progression
will
exacerbate
imbalance
microbiota,
thereby
forming
vicious
cycle.
This
suggests
further
exploration
identification
function
may
be
crucial
break
bottleneck
diagnosis
treatment
this
disease.
Hence,
current
review
summarizes
discusses
latest
research
advancement
future
directions
so
as
help
relevant
researchers
gain
correlative
information
instantly.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 20, 2023
Metabolic
abnormalities
lead
to
the
dysfunction
of
metabolic
pathways
and
metabolite
accumulation
or
deficiency
which
is
well-recognized
hallmarks
diseases.
Metabolite
signatures
that
have
close
proximity
subject's
phenotypic
informative
dimension,
are
useful
for
predicting
diagnosis
prognosis
diseases
as
well
monitoring
treatments.
The
lack
early
biomarkers
could
poor
serious
outcomes.
Therefore,
noninvasive
methods
with
high
specificity
selectivity
desperately
needed.
Small
molecule
metabolites-based
metabolomics
has
become
a
specialized
tool
biomarker
pathway
analysis,
revealing
possible
mechanisms
human
various
deciphering
therapeutic
potentials.
It
help
identify
functional
related
variation
delineate
biochemical
changes
indicators
pathological
damage
prior
disease
development.
Recently,
scientists
established
large
number
profiles
reveal
underlying
networks
target
exploration
in
biomedicine.
This
review
summarized
analysis
on
potential
value
small-molecule
candidate
metabolites
clinical
events,
may
better
diagnosis,
prognosis,
drug
screening
treatment.
We
also
discuss
challenges
need
be
addressed
fuel
next
wave
breakthroughs.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
Pharmacological Research,
Год журнала:
2023,
Номер
189, С. 106687 - 106687
Опубликована: Фев. 4, 2023
Accumulating
evidence
indicates
gut
microbiota
contributes
to
aging-related
disorders.
However,
the
exact
mechanism
underlying
dysbiosis-related
pathophysiological
changes
during
aging
remains
largely
unclear.
In
current
study,
we
first
performed
remodeling
on
old
mice
by
fecal
transplantation
(FMT)
from
young
mice,
and
then
characterized
bacteria
signature
that
was
specifically
altered
FMT.
Our
results
revealed
FMT
significantly
improved
natural
systemic
disorders,
particularly
exerted
hepatoprotective
effects,
glucose
sensitivity,
hepatosplenomegaly,
inflammaging,
antioxidative
capacity
intestinal
barrier.
Moreover,
increased
abundance
of
A.muciniphila,
which
almost
nondetectable
in
mice.
Interestingly,
A.muciniphila
supplementation
also
similar
benefits
with
Notably,
targeted
metabolomics
short
chain
fatty
acids
(SCFAs)
only
acetic
acid
consistently
reversed
Then,
intervention
beneficial
actions
both
Caenorhabditis
elegans
conclusion,
our
study
demonstrated
disorders
through
its
derived
acid,
suggesting
interventions
potent
stimulative
A.
muciniphila
growth
production
alternative
effective
way
maintain
healthy
aging.
The
data
RNAseq
16
S
rRNA
gene
sequencing
can
be
accessed
NCBI
accession
number
PRJNA848996
PRJNA849355.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 484 - 484
Опубликована: Апрель 18, 2024
The
antioxidant
and
anti-inflammatory
effects
of
hormetic
nutrition
for
enhancing
stress
resilience
overall
human
health
have
received
much
attention.
Recently,
the
gut-brain
axis
has
attracted
prominent
interest
preventing
therapeutically
impacting
neuropathologies
gastrointestinal
diseases.
Polyphenols
polyphenol-combined
nanoparticles
in
synergy
with
probiotics
shown
to
improve
gut
bioavailability
blood-brain
barrier
(BBB)
permeability,
thus
inhibiting
oxidative
stress,
metabolic
dysfunction
inflammation
linked
dysbiosis
ultimately
onset
progression
central
nervous
system
(CNS)
disorders.
In
accordance
hormesis,
polyphenols
display
biphasic
dose-response
by
activating
at
a
low
dose
Nrf2
pathway
resulting
upregulation
Ovarian
aging
occurs
prior
to
the
of
other
organ
systems
and
acts
as
pacemaker
process
multiple
organs.
As
life
expectancy
has
increased,
preventing
ovarian
become
an
essential
goal
for
promoting
extended
reproductive
function
improving
bone
genitourinary
conditions
related
in
women.
An
improved
understanding
may
ultimately
provide
tools
prediction
mitigation
this
process.
Recent
studies
have
suggested
a
connection
between
gut
microbiota,
alterations
composition
functional
profile
microbiota
profound
consequences
on
function.
The
interaction
ovaries
is
bidirectional.
In
review,
we
examine
current
knowledge
ovary-gut
crosstalk
further
discuss
potential
role
anti-aging
interventions.
Microbiota-based
manipulation
appealing
approach
that
offer
new
therapeutic
strategies
delay
or
reverse
aging.
Aging-related
abnormalities
in
gut
microbiota
are
associated
with
cognitive
decline,
depression,
and
anxiety,
but
underlying
mechanisms
remain
unstudied.
Here,
our
study
demonstrated
that
transplanting
old
to
young
mice
induced
inflammation
the
brain
coupled
anxiety.
We
observed
diminished
mucin
formation
increased
permeability
("leaky
gut")
a
reduction
beneficial
metabolites
like
butyrate
because
of
decline
butyrate-producing
bacteria
aged
microbiota.
This
led
suppressed
expression
receptors,
free
fatty
acid
receptors
2
3
(FFAR2/3).
Administering
alleviated
inflammation,
restored
barriers,
corrected
dysfunction.
Furthermore,
intestine-specific
loss
FFAR2/3
exhibited
akin
those
older
mice.
Our
results
demonstrate
reduced
result
low
levels
signaling,
leading
increases
permeability,
abnormalities.
These
findings
underscore
significance
butyrate-FFAR2/3
agonism
as
potential
strategy
mitigate
microbiota-induced
detrimental
effects
on
health
adults.
