Nutrients,
Год журнала:
2022,
Номер
14(20), С. 4303 - 4303
Опубликована: Окт. 14, 2022
Gestational
diabetes
mellitus
(GDM)is
one
of
the
most
common
perinatal
pathologies,
with
a
prevalence
5–20%
depending
on
population
or
diagnostic
standards.
It
is
diagnosed
when
glucose
intolerance
first
detected
during
pregnancy.
In
pathogenesis
GDM,
genetic,
environmental,
and
pregnancy-related
factors
(excessive
fat
storage
increased
adipokine
cytokine
secretion)
play
important
roles.
A
growing
amount
scientific
data
has
indicated
role
gut
microbiota
(GM)
dysbiosis
in
development
Previous
studies
have
that,
comparison
to
healthy
pregnant
women,
GDM
individuals
greater
abundance
bacteria
belonging
genera
Ruminococcus,
Eubacterium,
Prevotella
lower
number
Bacteroides,
Parabacteroides,
Roseburia,
Dialister,
Akkermansia.
Recently,
many
focused
treating
methods
targeting
GM.
Several
previous
analyzed
effect
probiotics
course
but
their
are
inconclusive.
view
this
state,
aim
study
was
collect
comprehensively
discuss
current
knowledge
regarding
probiotic
supplementation
preventing
GDM.
According
data,
positive
influence
glycemic
control
promising
tool
for
lowering
frequency
However,
further
must
be
conducted
determine
optimal
model
therapy
(strain,
dose,
time
intervention,
etc.)
women
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 19, 2023
Cognitive
function
in
humans
depends
on
the
complex
and
interplay
between
multiple
body
systems,
including
hypothalamic-pituitary-adrenal
(HPA)
axis.
The
gut
microbiota,
which
vastly
outnumbers
human
cells
has
a
genetic
potential
that
exceeds
of
genome,
plays
crucial
role
this
interplay.
microbiota-gut-brain
(MGB)
axis
is
bidirectional
signalling
pathway
operates
through
neural,
endocrine,
immune,
metabolic
pathways.
One
major
neuroendocrine
systems
responding
to
stress
HPA
produces
glucocorticoids
such
as
cortisol
corticosterone
rodents.
Appropriate
concentrations
are
essential
for
normal
neurodevelopment
function,
well
cognitive
processes
learning
memory,
studies
have
shown
microbes
modulate
throughout
life.
Stress
can
significantly
impact
MGB
via
other
Animal
research
advanced
our
understanding
these
mechanisms
pathways,
leading
paradigm
shift
conceptual
thinking
about
influence
microbiota
health
disease.
Preclinical
trials
currently
underway
determine
how
animal
models
translate
humans.
In
review
article,
we
summarize
current
knowledge
relationship
axis,
cognition,
provide
an
overview
main
findings
conclusions
broad
field.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Дек. 6, 2023
Gut-liver-brain
axis
is
a
three-way
highway
of
information
interaction
system
among
the
gastrointestinal
tract,
liver,
and
nervous
systems.
In
past
few
decades,
breakthrough
progress
has
been
made
in
gut
liver
brain
axis,
mainly
through
understanding
its
formation
mechanism
increasing
treatment
strategies.
this
review,
we
discuss
various
complex
networks
including
barrier
permeability,
hormones,
microbial
metabolites,
vagus
nerve,
neurotransmitters,
immunity,
toxic
β-amyloid
(Aβ)
metabolism,
epigenetic
regulation
gut-liver-brain
axis.
Some
therapies
containing
antibiotics,
probiotics,
prebiotics,
synbiotics,
fecal
microbiota
transplantation
(FMT),
polyphenols,
low
FODMAP
diet
nanotechnology
application
regulate
Besides,
some
special
treatments
targeting
gut-liver
include
farnesoid
X
receptor
(FXR)
agonists,
takeda
G
protein-coupled
5
(TGR5)
glucagon-like
peptide-1
(GLP-1)
antagonists
fibroblast
growth
factor
19
(FGF19)
analogs.
Targeting
gut-brain
embraces
cognitive
behavioral
therapy
(CBT),
antidepressants
tryptophan
metabolism-related
therapies.
liver-brain
contains
Aβ
future,
better
interactions
will
promote
development
novel
preventative
strategies
discovery
precise
therapeutic
targets
multiple
diseases.
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(7), С. 2645 - 2673
Опубликована: Янв. 27, 2023
Abstract
Bipolar
disorders
(BD)
represent
a
severe
leading
disabling
mental
condition
worldwide
characterized
by
episodic
and
often
progressive
mood
fluctuations
with
manic
depressive
stages.
The
biological
mechanisms
underlying
the
pathophysiology
of
BD
remain
incompletely
understood,
but
it
seems
that
there
is
complex
picture
genetic
environmental
factors
implicated.
Nowadays,
gut
microbiota
in
spotlight
new
research
related
to
this
kind
psychiatric
disorder,
as
can
be
consistently
several
pathophysiological
events
observed
BD.
In
context
so-called
microbiota–gut–brain
(MGB)
axis,
shown
have
strong
influence
on
host
neuromodulation
endocrine
functions
(i.e.,
controlling
synthesis
neurotransmitters
like
serotonin
or
mediating
activation
hypothalamic–pituitary–adrenal
axis),
well
modulation
immune
responses,
critically
regulating
intestinal,
systemic
brain
inflammation
(neuroinflammation).
present
review
aims
elucidate
derived
from
MGB
axis
disruption
possible
therapeutic
approaches
mainly
focusing
network
Understanding
its
bidirectional
communication
other
systems
shed
light
discovery
therapies
for
improving
clinical
management
these
patients.
Besides,
effect
drugs
currently
used
patients,
together
therapeutical
targeting
ecosystem
(dietary
patterns,
probiotics,
prebiotics,
novelties)
will
also
contemplated.
Considerable
evidence
has
been
reported
that
tobacco
use
could
cause
alterations
in
gut
microbiota
composition.
The
microbiota-gut-brain
axis
also
turn
hinted
at
a
possible
contribution
of
the
to
smoking.
However,
population-level
studies
with
higher
level
for
causality
are
lacking.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Фев. 9, 2024
The
human
brain
remains
one
of
the
greatest
challenges
for
modern
medicine,
yet
it
is
most
integral
and
sometimes
overlooked
aspects
medicine.
consists
roughly
100
billion
neurons,
trillion
neuronal
connections
consumes
about
20–25%
body’s
energy.
Emerging
evidence
highlights
that
insufficient
or
inadequate
nutrition
linked
to
an
increased
risk
health,
mental
psychological
functioning
compromise.
A
core
component
this
relationship
includes
intricate
dynamics
brain-gut-microbiota
(BGM)
system,
which
a
progressively
recognized
factor
in
sphere
mental/brain
health.
bidirectional
between
brain,
gut,
gut
microbiota
along
BGM
system
not
only
affects
nutrient
absorption
utilization,
but
also
exerts
substantial
influence
on
cognitive
processes,
mood
regulation,
neuroplasticity,
other
indices
Neuroplasticity
brain’s
capacity
adaptation
neural
regeneration
response
stimuli.
Understanding
neuroplasticity
considering
interventions
enhance
remarkable
ability
change
through
experience
constitutes
burgeoning
area
research
has
potential
improving
well-being,
resilience,
overall
health
optimal
lifestyle
interventions.
nexus
both
academic
clinical
perspectives
nutritional
neuroscience
emerges
as
potent
tool
patient
outcomes,
proactively
mitigate
challenges,
improve
management
treatment
existing
conditions
by
championing
health-promoting
dietary
patterns,
rectifying
deficiencies,
seamlessly
integrating
nutrition-centered
strategies
into
care.
Journal of Internal Medicine,
Год журнала:
2022,
Номер
292(6), С. 858 - 869
Опубликована: Июль 12, 2022
Abstract
Antibiotics
are
recognised
as,
on
occasion,
producing
psychiatric
side
effects,
most
notably
depression
and
anxiety.
Apart
from
antimicrobial
activity,
antibiotics
have
multiple
off‐target
effects.
The
brain–gut–microbiota
axis
has
sites
for
which
may
produce
either
positive
or
negative
antibiotic
Here
we
review
how
impact
mental
health
by
acting
through
the
axis.
Microbes
in
gut
influence
brain
function
vagus
nerve
altering
production
of
short‐chain
fatty
acids
amino
acid
tryptophan,
building
block
serotonin.
Not
all
actions
a
impact.
first
antidepressant
discovered
was
actually
an
antibiotic:
isoniazid
is
antibacterial
drug
developed
treating
tuberculosis.
Minocycline,
enters
mediates
its
effects
microglia,
shows
activity.
Some
bring
about
significant
decrease
microbial
diversity,
this
viewed
as
risk
factor
depression.
Other
factors
induced
include
altered
barrier
function,
activation
hypothalamic–pituitary–adrenal
axis,
reducing
levels
brain‐derived
neurotrophic
oxytocin
alteration
vagal
tone.
Although
patients
taking
do
not
suffer
iatrogenic
disorder,
some
do.
As
clinicians,
need
to
keep
mind.
development
new
primarily
focused
resistance,
but
efforts
should
be
made
reduce
resulting
problems.
The
significance
of
Bifidobacterium
to
human
health
can
be
appreciated
from
its
early
colonization
the
neonatal
gut,
where
longum
represents
most
abundant
species.
While
relative
abundance
declines
with
age,
it
is
further
reduced
in
several
diseases.
Research
into
beneficial
properties
B.
has
unveiled
a
range
mechanisms,
including
production
bioactive
molecules,
such
as
short-chain
fatty
acids,
polysaccharides,
and
serine
protease
inhibitors.
From
intestinal
niche,
have
far-reaching
effects
body
influencing
immune
responses
lungs
even
skin,
well
brain
activity.
In
this
review,
we
present
biological
clinical
impacts
species
on
conditions
beginning
life
beyond.
available
scientific
evidence
reveals
strong
rationale
for
continued
research
trials
that
investigate
ability
treat
or
prevent
diseases
across
lifespan.
Life,
Год журнала:
2023,
Номер
13(10), С. 2023 - 2023
Опубликована: Окт. 8, 2023
The
human
gut
microbiota
(GM)
is
a
complex
microbial
ecosystem
that
colonises
the
gastrointestinal
tract
(GIT)
and
comprised
of
bacteria,
viruses,
fungi,
protozoa.
GM
has
symbiotic
relationship
with
its
host
fundamental
for
body
homeostasis.
not
limited
to
scope
GIT,
but
there
are
bidirectional
interactions
between
other
organs,
highlighting
concept
"gut-organ
axis".
Any
deviation
from
normal
composition
GM,
termed
"microbial
dysbiosis",
implicated
in
pathogenesis
various
diseases.
Only
few
studies
have
demonstrated
modifications
disease
phenotypes,
it
still
unknown
whether
an
altered
contributes
or
simply
reflects
status.
Restoration
probiotics
prebiotics
been
postulated,
evidence
effects
limited.
Prebiotics
substrates
"selectively
utilized
by
microorganisms,
conferring
health
benefit".
This
study
highlights
vital
organs
demonstrates
dysbiosis
emergence
certain
representative
Finally,
this
article
focuses
on
potential
as
target
therapy
manipulate
presents
gaps
literature
research.
