Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Март 5, 2024

Fluorescence imaging in the second near-infrared window (NIR-II) is burgeoning because of its higher fidelity monitoring physiological and pathological processes than clinical visible/the fluorescence imaging. Notably, heavily dependent on agents. So far, indocyanine green, one polymethine dyes, with good biocompatibility renal clearance only dye approved by Food Drug Administration, but it shows relatively low NIR-II brightness. Importantly, tremendous efforts are devoted to synthesizing dyes for preclinically clinically. They have shown feasibility customization structure properties fulfill various needs therapy. Herein, a timely update special focus molecular design strategies fluorescent, photoacoustic, multimodal imaging, offered. Furthermore, progress sensing biomarkers even reporting drug release illustrated. Moreover, imaging-guided therapies summarized regarding chemo-, photothermal, photodynamic, approaches. In addition, artificial intelligence pointed out potential expedite development. This comprehensive review will inspire interest among wide audience offer handbook people an dyes.

Язык: Английский

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The significant role of amino acid metabolic reprogramming in cancer

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 29, 2024

Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming amino acids cells is intricately linked to protein synthesis, nucleotide modulation signaling pathways, regulation cell metabolism, maintenance oxidative stress homeostasis, and epigenetic modifications. Furthermore, the dysregulation also impacts microenvironment immunity. can act as molecules that modulate immune function tolerance within reshaping anti-tumor response promoting evasion by cells. Moreover, influence behavior stromal cells, such cancer-associated fibroblasts, regulate ECM remodeling promote angiogenesis, thereby facilitating growth metastasis. Understanding intricate interplay between crucial significance. Expanding our knowledge multifaceted roles holds significant promise for development more effective therapies aimed at disrupting dependencies modulating enhance responses inhibit

Язык: Английский

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Subchronic oral exposure to polystyrene microplastics affects hepatic lipid metabolism, inflammation, and oxidative balance in gilthead seabream (Sparus aurata)

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 279, С. 116455 - 116455

Опубликована: Май 20, 2024

Microplastics (MPs) pose a clear threat to aquatic organisms affecting their health. Their impact on liver homeostasis, as well the potential onset of nonalcoholic fatty disease (NAFLD), is still poorly investigated and remains almost unknown. The aim this study was evaluate outcomes subchronic exposure polystyrene MPs (PS-MPs; 1–20 μm; 0, 25, or 250 mg/kg b.w./day) lipid metabolism, inflammation, oxidative balance in gilthead seabreams (Sparus aurata Linnaeus, 1758) exposed for 21 days via contaminated food. PS-MPs induced an up-regulation mRNA levels crucial genes associated with synthesis storage (i.e., PPARy, Srebp1, Fasn) without modifications involved catabolism PPARα, HL, Pla2) transport metabolism (Fabp1) liver. increase CSF1R pro-inflammatory cytokines gene expression TNF-α IL-1β) also observed fish dose-dependent manner. These findings were confirmed by hepatic histological evaluations reporting evidence accumulation, necrosis. Moreover, caused impairment antioxidant defense system through alteration its enzymatic (catalase, superoxide dismutase, glutathione reductase) non-enzymatic (glutathione) components, resulting increased production reactive oxygen species (ROS) malondialdehyde (MDA), biomarkers damage. detoxifying enzymes inferred decreased Ethoxyresorufin-O-deethylase (EROD) activity glutathione-S-transferase (GST) at highest PS-MP dose. suggests that affect health seabream. dysfunction damage result from detrimental interplay damage, systems modifications, altering gut-liver axis homeostasis. This scenario suggestive involvement MP-induced effects progression

Язык: Английский

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Ferroptosis: mechanisms and therapeutic targets

MedComm, Год журнала: 2024, Номер 5(12)

Опубликована: Ноя. 20, 2024

Ferroptosis is a nonapoptotic form of cell death characterized by iron-dependent lipid peroxidation in membrane phospholipids. Since its identification 2012, extensive research has unveiled involvement the pathophysiology numerous diseases, including cancers, neurodegenerative disorders, organ injuries, infectious autoimmune conditions, metabolic and skin diseases. Oxidizable lipids, overload iron, compromised antioxidant systems are known as critical prerequisites for driving overwhelming peroxidation, ultimately leading to plasma rupture ferroptotic death. However, precise regulatory networks governing ferroptosis ferroptosis-targeted therapy these diseases remain largely undefined, hindering development pharmacological agonists antagonists. In this review, we first elucidate core mechanisms summarize epigenetic modifications (e.g., histone modifications, DNA methylation, noncoding RNAs, N6-methyladenosine modification) nonepigenetic genetic mutations, transcriptional regulation, posttranslational modifications). We then discuss association between disease pathogenesis explore therapeutic approaches targeting ferroptosis. also introduce potential clinical monitoring strategies Finally, put forward several unresolved issues which progress needed better understand hope review will offer promise application therapies context human health disease.

Язык: Английский

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Metallothionein Alleviates Glutathione Depletion–Induced Oxidative Cardiomyopathy through CISD1-Dependent Regulation of Ferroptosis in Murine Hearts

American Journal Of Pathology, Год журнала: 2024, Номер 194(6), С. 912 - 926

Опубликована: Фев. 28, 2024

Язык: Английский

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Reductive stress: The key pathway in metabolic disorders induced by overnutrition

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The balance of redox states is crucial for maintaining physiological homeostasis. For decades, the focus has been mainly on concept oxidative stress, which involved in mechanism almost all diseases. However, robust evidence highlighted that reductive other side spectrum, plays a pivotal role development various diseases, particularly those related to metabolism and cardiovascular health. In this review, we present an extensive array occurrence stress its significant implications metabolic Reductive defined as shift cellular towards more reduced state, characterized by excess endogenous reductants (such NADH, NADPH, GSH) over their oxidized counterparts (NAD+, NADP+, GSSG). While predominant studied obesity, disorders, growing underscores critical stress. This review discusses how contributes pathologies, emphasizing effects key processes. example, excessive NADH accumulation can disrupt mitochondrial function impairing electron transport chain, leading decreased ATP production increased reactive oxygen species. endoplasmic reticulum (ER), equivalents hampers protein folding, triggering ER activating unfolded response, lead insulin resistance compromised Furthermore, explore antioxidant supplementation exacerbate further shifting balance, potentially undermining beneficial exercise, health, aggravating obese individuals. body calls reevaluation disease pathogenesis therapeutic interventions.

Язык: Английский

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Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Aging Cell, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases. It has long been speculated that “rejuvenation molecules” exist in their blood promote extended lifespan. We unexpectedly discovered longevity exhibit erythrocyte oxygen release function similar young individuals, whereas most elderly show reduced capacity. Untargeted metabolomics profiling revealed are characterized by youth‐like metabolic reprogramming these metabolites effectively differentiate the from elderly. Quantification analyses led us identify multiple novel longevity‐related within erythrocytes including adenosine, sphingosine‐1‐phosphate (S1P), glutathione (GSH) related amino acids. Mechanistically, we increased bisphosphoglycerate mutase (BPGM) MFSD2B protein levels of collaboratively work together induce elevation intracellular S1P, glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) membrane cytosol, thereby orchestrate glucose toward Rapoport–Luebering Shunt 2,3‐BPG production trigger delivery. Furthermore, glutamine glutamate transporter expression coupled with enhanced metabolism underlie elevated GSH higher anti‐oxidative stress capacity individuals. As such, displayed less systemic hypoxia‐related more antioxidative anti‐inflammatory plasma, healthier clinical outcomes inflammation parameters as well better glucose–lipid metabolism, liver kidney function. Overall, identified youthful enable counteract peripheral tissue thus maintaining healthspan.

Язык: Английский

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Role of iron in brain development, aging, and neurodegenerative diseases

Annals of Medicine, Год журнала: 2025, Номер 57(1)

Опубликована: Март 4, 2025

It is now understood that iron crosses the blood-brain barrier via a complex metabolic regulatory network and participates in diverse critical biological processes within central nervous system, including oxygen transport, energy metabolism, synthesis catabolism of myelin neurotransmitters. During brain development, distributed throughout brain, playing pivotal role key such as neuronal myelination, neurotransmitter synthesis. In physiological aging, can selectively accumulate specific regions, impacting cognitive function leading to intracellular redox imbalance, mitochondrial dysfunction, lipid peroxidation, thereby accelerating aging associated pathologies. Furthermore, accumulation may be primary contributor neurodegenerative diseases Alzheimer's Parkinson's diseases. Comprehending diseases, utilizing iron-sensitive Magnetic Resonance Imaging (MRI) technology for timely detection or prediction abnormal neurological states, implementing appropriate interventions instrumental preserving normal system function.

Язык: Английский

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Metal-organic framework-based nanozymes for water-soluble antioxidants and Total antioxidant capacity detection: Principles and applications

Food Chemistry, Год журнала: 2025, Номер unknown, С. 143876 - 143876

Опубликована: Март 1, 2025

Язык: Английский

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Unveiling the Significance of Peroxiredoxin 6 in Central Nervous System Disorders

Antioxidants, Год журнала: 2024, Номер 13(4), С. 449 - 449

Опубликована: Апрель 10, 2024

Peroxiredoxin 6 (Prdx6), a unique 1-Cys member of the peroxiredoxin family, exhibits peroxidase activity, phospholipase and lysophosphatidylcholine acyltransferase (LPCAT) activity. Prdx6 has been known to be an important enzyme for maintenance lipid peroxidation repair, cellular metabolism, inflammatory signaling, antioxidant damage. Growing research demonstrated that altered activity this is linked with various pathological processes including central nervous system (CNS) disorders. This review discusses distinctive structure, function in different CNS disorders, as well emphasizing significance neurological

Язык: Английский

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