Association of high-fat diet with neuroinflammation, anxiety-like defensive behavioral responses, and altered thermoregulatory responses in male rats DOI Creative Commons

S.S.R. Noronha,

Paulo M. A. Lima,

Glenda Siqueira Viggiano Campos

и другие.

Brain Behavior and Immunity, Год журнала: 2019, Номер 80, С. 500 - 511

Опубликована: Апрель 23, 2019

Overweight and obesity are a worldwide pandemic affecting billions of people. These conditions have been associated with chronic low-grade inflammatory state that is recognized as risk factor for range somatic diseases well neurodevelopmental disorders, anxiety trauma- stressor-related affective disorders. We previously reported the ingestion high-fat diet (HFD; 45% fat kcal/g) nine weeks was capable inducing in rats association increased reactivity to stress anxiety-related defensive behavior. In this study, we conducted nine-week protocol induce rats, followed by investigation behavioral responses using elevated T-maze (ETM), numbers FOS-immunoreactive cells after exposure avoidance or escape task ETM, neuroinflammatory cytokine expression hypothalamic amygdaloid nuclei. addition, investigated stress-induced cutaneous thermoregulatory during an open-field (OF). Here demonstrated HFD intake induced obesity, abdominal pad weight, responses, proinflammatory cytokines altered avoidance- task-induced FOS-immunoreactivity within brain structures involved control neuroendocrine, autonomic, aversive stimuli, including basolateral amygdala (BLA) dorsomedial (DMH), paraventricular (PVN) ventromedial (VMH) Furthermore, exposed HFD, relative diet-fed responded tail skin temperature at baseline throughout apparatus. data consistent hypothesis induces neuroinflammation, alters excitability nuclei controlling stressful enhances anxiety-like responses.

Язык: Английский

Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala DOI
Zhi-Heng Zheng,

Jiang-Long Tu,

Xiaohan Li

и другие.

Brain Behavior and Immunity, Год журнала: 2020, Номер 91, С. 505 - 518

Опубликована: Ноя. 6, 2020

Язык: Английский

Процитировано

207
Amygdala Circuit Substrates for Stress Adaptation and Adversity DOI Creative Commons
Wen-Hua Zhang, Junyu Zhang, Andrew Holmes

и другие.

Biological Psychiatry, Год журнала: 2021, Номер 89(9), С. 847 - 856

Опубликована: Янв. 8, 2021

Brain systems that promote maintenance of homeostasis in the face stress have significant adaptive value. A growing body work across species demonstrates a critical role for amygdala promoting by regulating physiological and behavioral responses to stress. This review focuses on an emerging evidence has begun delineate contribution specific long-range circuits mediating effects After summarizing major anatomical features its connectivity other limbic structures, we discuss recent findings from rodents showing how causes structural functional remodeling neuronal outputs defined cortical subcortical target regions. We also consider some environmental genetic factors been found moderate responds relate preclinical literature current understanding pathophysiology treatment stress-related neuropsychiatric disorders. Future effort translate these clinics may help develop valuable tools prevention, diagnosis, diseases.

Язык: Английский

Процитировано

142
Nature-based biopsychosocial resilience: An integrative theoretical framework for research on nature and health DOI Creative Commons
Mathew P. White, Terry Hartig, Leanne Martin

и другие.

Environment International, Год журнала: 2023, Номер 181, С. 108234 - 108234

Опубликована: Сен. 27, 2023

Nature-based solutions including urban forests and wetlands can help communities cope better with climate change other environmental stressors by enhancing social-ecological resilience. Natural ecosystems, settings, elements affordances also individuals become more personally resilient to a variety of stressors, although the mechanisms underpinning individual-level nature-based resilience, their relations are not well articulated. We propose 'nature-based biopsychosocial resilience theory' (NBRT) address these gaps. Our framework begins suggesting that refer both: a) person's set adaptive resources; b) processes which resources deployed. Drawing on existing nature-health perspectives, we argue nature contact support build maintain biological, psychological, social (i.e. biopsychosocial) resilience-related resources. Together can: i) reduce risk various (preventive resilience); ii) enhance reactions stressful circumstances (response resilience), and/or iii) facilitate rapid complete recovery from stress (recovery resilience). Reference three supports integration across familiar pathways involving harm reduction, capacity building, restoration. Evidence in theory, potential interventions promote issues require further consideration discussed.

Язык: Английский

Процитировано

56
Stress-Induced Functional Alterations in Amygdala: Implications for Neuropsychiatric Diseases DOI Creative Commons
Xin Zhang, Tongtong Ge,

Guanghao Yin

и другие.

Frontiers in Neuroscience, Год журнала: 2018, Номер 12

Опубликована: Май 29, 2018

The amygdala plays a major role in the processing of physiologic and behavioral responses to stress is charactered by gamma-aminobutyric acid (GABA)-mediated high inhibitory tone under resting state. Human animal studies showed that lead hyperactivity amygdala, which was accompanied removal control. However, contribution stress-induced neuropsychiatric diseases, such as anxiety mood disorders, still dubious. In this review, we will summarize various structural functional alterations including GABA receptors expression, GABAergic transmission synaptic plasticity. It may provide new insight on neuropathologic neurophysiological mechanisms diseases.

Язык: Английский

Процитировано

100
Connectivity characterization of the mouse basolateral amygdalar complex DOI Creative Commons
Houri Hintiryan, Ian Bowman, David L. Johnson

и другие.

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Май 17, 2021

The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile projection neurons inform granular, type-specific interrogations warranted. Here, we apply machine-learning based computational informatics analysis techniques results circuit-tracing experiments create foundational, comprehensive map. analyses identify three distinct domains within anterior (BLAa) that house target-specific with distinguishable morphological features. We brain-wide targets BLAa domains, as well posterior BLA, ventral basomedial, lateral nuclei. Inputs each nucleus also are identified via retrograde tracing. data suggests connectionally unique, domain-specific associated behavior networks.

Язык: Английский

Процитировано

100
Die COVID-19-Pandemie als Herausforderung für die psychische Gesundheit DOI
Eva‐Lotta Brakemeier, Janine Wirkner, Christine Knaevelsrud

и другие.

Zeitschrift für Klinische Psychologie und Psychotherapie, Год журнала: 2020, Номер 49(1), С. 1 - 31

Опубликована: Янв. 1, 2020

Zusammenfassung. Die COVID-19-Pandemie als multidimensionaler und potenziell toxischer Stressfaktor führt auch in Deutschland zu psychischen Problemen der Allgemeinbevölkerung wird voraussichtlich einen Anstieg Inzidenz- Prävalenzraten psychischer Störungen bedingen. In diesem Positionspapier erfolgt daher eine wissenschaftlich differenzierte Betrachtung psychologischen Auswirkungen auf verschiedene Altersstufen sowie psychische Vulnerabilitäten Störungsbilder, wobei Chancen für die Gesundheit psychotherapeutische Versorgung diskutiert werden. Basierend den Befunden werden abschließend u. a. folgende gesundheitspolitische Ziele Maßnahmen abgeleitet: Implementierung von universellen indizierten modularen Präventionsangeboten Anpassung evidenzbasierten Richtlinienpsychotherapien hinsichtlich Bedarf, Inhalt Modalität. Klinische Psychologie Psychotherapie stellt aufgrund ihrer ausgewiesenen Expertise im Bereich zentrales Wissen erfolgreiche Bewältigung zur Verfügung kann interdisziplinären interprofessionellen Kooperationen dazu beitragen, Herausforderungen anzugehen.

Процитировано

91
Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors DOI Creative Commons
Thibault P. Bittar, Benoît Labonté

Frontiers in Behavioral Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Июнь 21, 2021

Despite decades of research on the neurobiology major depressive disorder (MDD), mechanisms underlying its expression remain unknown. The medial prefrontal cortex (mPFC), a hub region involved in emotional processing and stress response elaboration, is highly impacted MDD patients animal models chronic stress. Recent advances showed alterations morphology activity mPFC neurons along with profound changes their transcriptional programs. Studies at circuitry level highlighted relevance deciphering contributions distinct circuits elaboration adapted maladapted behavioral responses context Interestingly, presents sexual dimorphism, feature recognized molecular field but understudied circuit level. This review examines recent literature summarizes contribution males females morphological functional that change these neuronal human depressive-like behaviors.

Язык: Английский

Процитировано

61
Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma DOI
Jennifer S. Stevens, Nathaniel G. Harnett, Lauren A. M. Lebois

и другие.

American Journal of Psychiatry, Год журнала: 2021, Номер 178(11), С. 1037 - 1049

Опубликована: Окт. 14, 2021

Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating and the of these events unfolding new psychopathology is not well understood. The authors conducted multisite transdiagnostic longitudinal study exposure related mental health outcomes identify neurobiological predictors risk, resilience, different symptom presentations.

Язык: Английский

Процитировано

61
The role of social isolation in opioid addiction DOI Creative Commons
Nina C. Christie

Social Cognitive and Affective Neuroscience, Год журнала: 2021, Номер 16(7), С. 645 - 656

Опубликована: Март 3, 2021

Humans are social animals: isolation hurts people both psychologically and physically. Strong, positive bonds help to live longer healthier lives compared with their more isolated peers. Opioid use disorder is associated feelings of isolation, an increased risk suicide and, at the community level, lower capital. I propose a psychobiological mechanistic explanation that contributes association between opioid isolation. The endogenous system plays central role in formation maintenance across life span has been investigated primarily through framework brain theory attachment. In primates, maternal-infant bonding play impaired by administration naltrexone (an antagonist), humans, chronic opioids appears be particularly (relative other drugs) corrosive close relationships. Social may development exacerbation disorder. Taken together, work on brain's suggests possible basis for bidirectional causal links Evaluation this hypothesis would benefit from longitudinal psychosocial neuropsychopharmacological investigations.

Язык: Английский

Процитировано

58
Mini-review: The neurobiology of treating substance use disorders with classical psychedelics DOI Creative Commons

Marvin M. Urban,

Moritz R. Stingl,

Marcus W. Meinhardt

и другие.

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Апрель 17, 2023

The potential of psychedelics to persistently treat substance use disorders is known since the 1960s. However, biological mechanisms responsible for their therapeutic effects have not yet been fully elucidated. While it that serotonergic hallucinogens induce changes in gene expression and neuroplasticity, particularly prefrontal regions, theories on how specifically this counteracts alterations occur neuronal circuitry throughout course addiction are largely unknown. This narrative mini-review endeavors synthesize well-established knowledge from research with findings regarding neurobiological give an overview underlie treatment classical hallucinogenic compounds point out gaps current understanding.

Язык: Английский

Процитировано

42