Air pollution and epigenetic aging among Black and White women in the US DOI Creative Commons
Sarah H. Koenigsberg, Che-Jung Chang, Jennifer Ish

и другие.

Environment International, Год журнала: 2023, Номер 181, С. 108270 - 108270

Опубликована: Окт. 17, 2023

DNA methylation-based measures of biological aging have been associated with air pollution and may link pollutant exposures to aging-related health outcomes. However, evidence is inconsistent there little information for Black women. We examined associations ambient particulate matter <2.5 μm <10 in diameter (PM2.5 PM10) nitrogen dioxide (NO2) methylation, including epigenetic individual CpG sites, evaluated whether differ between non-Hispanic White (NHW) Validated models were used estimate annual average outdoor residential exposure PM2.5, PM10, NO2 a sample self-identified (n=633) NHW (n=3,493) women residing the contiguous US. sampling-weighted generalized linear regression examine effects pollutants on six (primary: DunedinPACE, GrimAgeAccel, PhenoAgeAccel; secondary: Horvath intrinsic age acceleration [EAA], Hannum extrinsic EAA, skin & blood EAA) epigenome-wide sites. Wald tests nested without interaction terms effect measure modification by race/ethnicity. participants had higher median than participants. GrimAgeAccel was both PM10 among participants, (Q4 vs Q1, PM10: β=1.09, 95% CI: 0.16-2.03; NO2: β=1.01, CI 0.08-1.94) but not (p-for-heterogeneity: PM10=0.10, NO2=0.20). In we also observed monotonic exposure-response relationship DunedinPACE β=0.029, 0.004-0.055; p-for-trend=0.03), which (p-for-heterogeneity=0.09). EWAS, significantly differential methylation at 19 sites one US-wide cohort study, our findings suggest that alterations consistent Black, NHW,

Язык: Английский

The Mortality and Medical Costs of Air Pollution: Evidence from Changes in Wind Direction DOI
Tatyana Deryugina, Garth Heutel,

Nolan Miller

и другие.

American Economic Review, Год журнала: 2019, Номер 109(12), С. 4178 - 4219

Опубликована: Ноя. 26, 2019

We estimate the causal effects of acute fine particulate matter exposure on mortality, health care use, and medical costs among US elderly using Medicare data. instrument for air pollution changes in local wind direction develop a new approach that uses machine learning to life-years lost due exposure. Finally, we characterize treatment effect heterogeneity both life expectancy generic inference. Both approaches find mortality are concentrated about 25 percent population.

Язык: Английский

Процитировано

598
Long‐Term PM 2.5 Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta‐Analysis DOI Creative Commons
Stacey E. Alexeeff, Noelle S. Liao, Xi Liu

и другие.

Journal of the American Heart Association, Год журнала: 2020, Номер 10(1)

Опубликована: Дек. 31, 2020

Background Fine particulate matter <2.5 µm in diameter (PM 2.5 ) has known effects on cardiovascular morbidity and mortality. However, no study quantified compared the risks of incident myocardial infarction, stroke, ischemic heart disease (IHD) mortality, cerebrovascular mortality relation to long‐term PM exposure. Methods Results We sought quantitatively summarize studies exposure risk IHD stroke events by conducting a review meta‐analysis published December 31, 2019. The main outcomes were Random meta‐analyses used estimate combined each outcome among studies. reviewed 69 included 42 meta‐analyses. In meta‐analyses, we found that 10‐µg/m 3 increase was associated with an increased 23% for (95% CI, 15%–31%), 24% 13%–36%), 13% 11%–15%), 8% infarction −1% 18%). There insufficient number recurrent conduct Conclusions Long‐term is stroke. relationship suggestive but not conclusive. More research needed understand events.

Язык: Английский

Процитировано

200
The Impact of Fine Particulate Matter 2.5 on the Cardiovascular System: A Review of the Invisible Killer DOI Creative Commons
Shaherin Basith, Balachandran Manavalan, Tae Hwan Shin

и другие.

Nanomaterials, Год журнала: 2022, Номер 12(15), С. 2656 - 2656

Опубликована: Авг. 2, 2022

Air pollution exerts several deleterious effects on the cardiovascular system, with disease (CVD) accounting for 80% of all premature deaths caused by air pollution. Short-term exposure to particulate matter 2.5 (PM2.5) leads acute CVD-associated and nonfatal events, whereas long-term increases risk death reduces longevity. Here, we summarize published data illustrating how PM2.5 may impact system provide information mechanisms which it contribute CVDs. We an overview PM2.5, its associated health risks, global statistics, mechanistic underpinnings related mitochondria, hazardous biological effects. elaborate association between CVD development examine preventive measures future strategies combating PM2.5-related adverse The insights gained can critical guidelines preventing pollution-related CVDs through governmental, societal, personal measures, thereby benefitting humanity slowing climate change.

Язык: Английский

Процитировано

103
Particulate Matter Air Pollution is a Significant Risk Factor for Cardiovascular Disease DOI
Robert J. Henning

Current Problems in Cardiology, Год журнала: 2023, Номер 49(1), С. 102094 - 102094

Опубликована: Сен. 19, 2023

Язык: Английский

Процитировано

49
Cell death pathways of particulate matter toxicity DOI

Milena Simões Peixoto,

Marcos Felipe de Oliveira Galvão, Sílvia Regina Batistuzzo de Medeiros

и другие.

Chemosphere, Год журнала: 2017, Номер 188, С. 32 - 48

Опубликована: Авг. 21, 2017

Язык: Английский

Процитировано

151
Detection of Microplastics in Ambient Particulate Matter Using Raman Spectral Imaging and Chemometric Analysis DOI
Joseph Levermore, Thomas E. L. Smith, Frank J. Kelly

и другие.

Analytical Chemistry, Год журнала: 2020, Номер 92(13), С. 8732 - 8740

Опубликована: Июнь 22, 2020

Microplastics have been observed in indoor and outdoor air. This raises concern for human exposure, especially should they occur small enough sizes, which if inhaled, reach the central airway distal lung. As yet, methods their detection not spectroscopically verified chemical composition of microplastics this size-range. One proposed method is an automated spectroscopic technique, Raman spectral imaging; however, generates large complex data sets. study aims to optimize imaging identification (≥2 μm) ambient particulate matter, using different chemometric techniques. We show that images analyzed statistical approaches are appropriate both virgin environmental ≥2 μm size. On basis sensitivity, we recommend developed Pearson's correlation agglomerative hierarchical cluster analysis Finally, applicability by identifying airborne >4.7 matter sample obtained at urban sampling site London, United Kingdom. semiquantitative will enable procurement exposure concentrations guiding future toxicological assessments.

Язык: Английский

Процитировано

137
Particulate Matter Toxicity Is Nrf2 and Mitochondria Dependent: The Roles of Metals and Polycyclic Aromatic Hydrocarbons DOI Creative Commons
Michal Pardo, Xinghua Qiu, Ralf Zimmermann

и другие.

Chemical Research in Toxicology, Год журнала: 2020, Номер 33(5), С. 1110 - 1120

Опубликована: Апрель 17, 2020

Particulate matter (PM), an important component of air pollution, induces significant adverse health effects. Many the observed effects caused by inhaled PM are associated with oxidative stress and inflammation. This association has been linked in particular to particles' chemical components, especially inorganic/metal organic/polycyclic aromatic hydrocarbon (PAH) fractions, their ability generate reactive oxygen species biological systems. The transcription factor NF-E2 nuclear erythroid-related 2 (Nrf2) is activated redox imbalance regulates expression phase II detoxifying enzymes. Nrf2 plays a key role preventing PM-induced toxicity protecting against damage review focuses on specific particularly dissolved metals PAH roles inducing inflammation cell animal models respect mitochondria.

Язык: Английский

Процитировано

114
Interactions of particulate matter and pulmonary surfactant: Implications for human health DOI Open Access
Feifei Wang,

Jifang Liu,

Hongbo Zeng

и другие.

Advances in Colloid and Interface Science, Год журнала: 2020, Номер 284, С. 102244 - 102244

Опубликована: Авг. 19, 2020

Язык: Английский

Процитировано

82
Urbanization, ambient air pollution, and prevalence of chronic kidney disease: A nationwide cross-sectional study DOI Creative Commons
Ze Liang, Wanzhou Wang, Yueyao Wang

и другие.

Environment International, Год журнала: 2021, Номер 156, С. 106752 - 106752

Опубликована: Июль 10, 2021

An increasing number of studies have linked ambient air pollution to chronic kidney disease (CKD) prevalence. However, its potential effect modification by urbanization has not been investigated. Based on data 47,204 adults from the China National Survey Chronic Kidney Disease (CKSCKD) dataset, night light satellite remote sensing and high-resolution inversion products, present cross-sectional study investigated association between fine particulate matter <2.5 mm in diameter (PM2.5), nitrogen dioxide (NO2), index (NLI) CKD prevalence China, characterized administrative classification NLI pollutant-health associations. Our results showed that a 10-μg/m3 increase PM2.5 at 3-year moving average, NO2 5-year 10-U average were significantly associated with increased odds [OR = 1.24 (95 %CI:1.14, 1.35); OR 1.12 %CI:1.09, 1.15); 1.05 %CI:1.02, 1.07)]. Meanwhile, associations more apparent medium-urbanized areas compared low- high-urbanized areas. For instance, concentration 2-year was level second 2.78 %CI:1.77, 4.36)] third quartiles 1.49 1.95)], lowest 0.96 (95% CI: 0.73, 1.26)] highest 0.63 0.39–1.02)] quartiles. prevalence, especially medium levels, suggesting necessity strengthening environmental management regions.

Язык: Английский

Процитировано

68
PM2.5 constituents associated with childhood obesity and larger BMI growth trajectory: A 14-year longitudinal study DOI Creative Commons
Y Q Wang, Weiming Li, Shuo Chen

и другие.

Environment International, Год журнала: 2024, Номер 183, С. 108417 - 108417

Опубликована: Янв. 1, 2024

The association of specific PM2.5 chemical constituents with childhood overweight or obesity (OWOB) remain unclear. Furthermore, the long-term impacts exposure on trajectory children's body mass index (BMI) have not been explored. We conducted a longitudinal study among 1,450,830 Chinese children aged 6-19 years from Beijing and Zhongshan in China during 2005-2018 to examine associations its incident OWOB risk. extracted five main component Tracking Air Pollution (TAP) dataset. Cox proportional hazards models were applied quantify exposure-response associations. further performed principal analysis (PCA) handle multi-collinearity used quantile g-computation (QGC) approach analyze mixtures. Additionally, we selected 125,863 at least 8 physical examination measurements combined group-based (GBTM) multinomial logistic regression explore BMI Z-score trajectories years. observed each interquartile range increment was significantly associated 5.1% increase risk (95% confidence Interval [CI]: 1.036-1.066). also found black carbon, sulfate, organic matter, often linked fossil combustion, had comparable larger estimates effect (HR = 1.139-1.153) than PM2.5. Exposure mass, nitrate, ammonium, matter carbon an increased odds being assigned persistent trajectory. Our findings provide evidence that mainly fuel combustion may perceptible influence China. Moreover, contributes lager trajectories.

Язык: Английский

Процитировано

14