Selenium Nanoparticles-Enriched Lactobacillus casei ATCC 393 Prevents Cognitive Dysfunction in Mice Through Modulating Microbiota-Gut-Brain Axis DOI Creative Commons
Lei Qiao, Yue Chen,

Xiaofan Song

и другие.

International Journal of Nanomedicine, Год журнала: 2022, Номер Volume 17, С. 4807 - 4827

Опубликована: Окт. 1, 2022

Purpose: The bidirectional communication between the gut and central nervous system mediated by microbiota is closely related to occurrence development of neurodegenerative diseases, including Alzheimer’s disease (AD). Selenium (Se) has been identified as playing a role against AD. Probiotics have beneficial effects on host brain function behavior modulating microbiota-gut-brain axis. Herein, we evaluated protective Lactobacillus casei ATCC 393 ( L. 393) selenium nanoparticles-enriched 393-SeNPs) D-galactose/aluminum chloride-induced AD model mice. Methods: Morris Water Maze (MWM) test was used assess cognitive morphology histopathological changes, antioxidant capacity immune responses in ileum were evaluated. alterations intestinal permeability mice determined using FITC-dextran. Gut composition assessed 16s rRNA sequencing. Results: Thirteen weeks intervention with or 393-SeNPs significantly improved dysfunction, minimized amyloid beta (Aβ) aggregation, hyperphosphorylation TAU protein, prevented neuronal death Akt/cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway. Moreover, compared 393, further effectively mitigated barrier dysfunction improving capacity, regulating response, restoring balance, increasing level short-chain fatty acids neurotransmitters, thereby inhibiting activation microglia protecting neurons from neurotoxicity such oxidative stress neuroinflammation. Conclusion: These findings indicated that targeting axis may therapeutic potential for deficits Thus, anticipate be promising safe Se nutritional supplement use food additive prevent disease. Graphical Abstract: Keywords: disease, microbiota, stress, neuroinflammation

Язык: Английский

d-Galactose-induced accelerated aging model: an overview DOI
Khairunnuur Fairuz Azman, Rahimah Zakaria

Biogerontology, Год журнала: 2019, Номер 20(6), С. 763 - 782

Опубликована: Сен. 20, 2019

Язык: Английский

Процитировано

358
Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway DOI Creative Commons
Xiaojuan Zhao,

Hanwen Yu,

Yan‐Zi Yang

и другие.

Redox Biology, Год журнала: 2018, Номер 18, С. 124 - 137

Опубликована: Июль 5, 2018

Oxidative stress is a critical factor in nonalcoholic fatty liver disease pathogenesis. MicroRNA-200a (miR-200a) reported to target Kelch-like ECH-associated protein 1 (Keap1), which regulates nuclear erythroid 2-related 2 (Nrf2) anti-oxidant pathway. Polydatin (3,4′,5-trihydroxy-stilbene-3-β-D-glucoside), polyphenol found the rhizome of Polygonum cuspidatum, have anti-oxidative, anti-inflammatory and anti-hyperlipidemic effects. However, whether miR-200a controls Keap1/Nrf2 pathway fructose-induced inflammation lipid deposition blockade polydatin are still not clear. Here, we detected down-regulation, Keap1 up-regulation, Nrf2 antioxidant inactivation, ROS-driven thioredoxin-interacting (TXNIP) over-expression, NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome activation dysregulation peroxisome proliferator activated receptor-α (PPAR-α), carnitine palmitoyl transferase-1 (CPT-1), sterol regulatory element binging (SREBP-1) stearoyl-CoA desaturase-1 (SCD-1) rat livers, BRL-3A HepG2 cells under high fructose induction. Furthermore, data from treatment or transfection minic, TXNIP siRNA, activator ROS inhibitor demonstrated that low-expression increased block pathway, then enhanced activate NLRP3 disturb metabolism-related proteins, causing cells. We also up-regulated inhibit resulting attenuation these disturbances animal cell models. These findings provide novel pathological mechanism redox status imbalance suggest enhancement control by therapeutic strategy for fructose-associated deposition.

Язык: Английский

Процитировано

217
Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer’s Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota DOI
Changjiang Li, Na Wang, Guodong Zheng

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(39), С. 46406 - 46420

Опубликована: Сен. 27, 2021

Alzheimer's disease (AD) is a neurodegenerative associated with amyloid-β (Aβ) deposition, leading to neurotoxicity (oxidative stress and neuroinflammation) gut microbiota imbalance. Resveratrol (Res) has neuroprotective properties, but its bioavailability

Язык: Английский

Процитировано

107
Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits DOI Creative Commons

Ahmad Karami,

Sajad Fakhri, Leila Kooshki

и другие.

Molecules, Год журнала: 2022, Номер 27(19), С. 6474 - 6474

Опубликована: Окт. 1, 2022

Polydatin is a natural potent stilbenoid polyphenol and resveratrol derivative with improved bioavailability. possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, apoptosis. Various imperative have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well health-promoting roles on renal system, respiratory rheumatoid diseases, skeletal women's health. In present study, targets, activities, pharmacological mechanisms, health benefits are reviewed to provide new insights researchers. The need develop further clinical trials novel delivery systems also considered reveal

Язык: Английский

Процитировано

72
Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose DOI Creative Commons
Peng Chen, Fuchao Chen, Benhong Zhou

и другие.

Scientific Reports, Год журнала: 2018, Номер 8(1)

Опубликована: Янв. 17, 2018

Accumulating evidence has suggested that oxidative stress and apoptosis are involved in the ageing process. D-galactose (gal) been reported to cause symptoms of rats, accompanied by liver brain injuries. Our study aimed investigate potential antioxidative, anti-inflammatory anti-apoptotic effects ellagic acid explore how these act on rats a D-gal-induced model. Ageing was induced subcutaneous injection D-gal (100 mg/kg/d for 8 weeks). Ellagic simultaneously administered once daily intragastric gavage. Finally, mental condition, body weight, organ index, levels inflammatory cytokines, antioxidative enzymes, function, as well expression pro- proteins, were monitored. results showed could improve index significantly decrease normalize activities modulate apoptotic protein rats. In conclusion, this illustrate suitable treatment some ageing-associated problems, such stress, had beneficial age-associated diseases.

Язык: Английский

Процитировано

151
Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO-1 pathway DOI

Runxiao Lv,

Lili Du, Lixin Zhang

и другие.

Life Sciences, Год журнала: 2018, Номер 217, С. 119 - 127

Опубликована: Ноя. 24, 2018

Язык: Английский

Процитировано

133
Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways DOI Creative Commons
Jing Ye, Hongmei Piao, Jingzhi Jiang

и другие.

Scientific Reports, Год журнала: 2017, Номер 7(1)

Опубликована: Сен. 13, 2017

Polydatin(PD) shows anti-allergic inflammatory effect, and this study investigated its underlying mechanisms in vitro vivo models. IgE-mediated passive cutaneous anaphylaxis (PCA) systemic (PSA) models were used to confirm PD effect vivo. Various signaling pathway proteins mast cell examined. RT-PCR, ELISA western blotting applied when appropriate. Activity of Lyn Fyn kinases was measured using the Kinase Enzyme System. dose-dependently reduced pigmentation Evans blue PCA model decreased concentration serum histamine PSA model, attenuated degranulation cells without generating cytotoxicity. pro-inflammatory cytokine expression (TNF-α, IL-4, IL-1β, IL-8). directly inhibited activity Syk down-regulated downstream including MAPK, PI3K/AKT NF-kB. In addition, also targets Nrf2/HO-1 inhibit cell-derived allergic reactions. conclusion, demonstrates that is a possible therapeutic candidate for diseases. It down-regulates NF-κB, up-regulates cells.

Язык: Английский

Процитировано

107
Current Perspective in the Discovery of Anti-aging Agents from Natural Products DOI Creative Commons
Aijun Ding, Shanqing Zheng, Xiaobing Huang

и другие.

Natural Products and Bioprospecting, Год журнала: 2017, Номер 7(5), С. 335 - 404

Опубликована: Май 31, 2017

Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal aging research to develop therapies that delay age-related diseases human. Since signaling pathways Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan them intervening may be useful treating Natural products have special resource advantage with few side effect. Recently, many or extracts from natural slowing been reported. Here we summarized these their mechanisms increasing longevity C. other species, prospect developing anti-aging medicine products.

Язык: Английский

Процитировано

101
Ginsenoside Rg1 prevent and treat inflammatory diseases: A review DOI
Yan Gao,

Juntong Li,

Jin Wang

и другие.

International Immunopharmacology, Год журнала: 2020, Номер 87, С. 106805 - 106805

Опубликована: Июль 27, 2020

Язык: Английский

Процитировано

77
Ovarian Dysfunction Induced by Chronic Whole‐Body PM2.5 Exposure DOI Creative Commons
Su Zhou,

Yueyue Xi,

Yingying Chen

и другие.

Small, Год журнала: 2020, Номер 16(33)

Опубликована: Июль 19, 2020

Fine particulate matter (PM2.5) pollution arouses public health concerns over the world. Increasing epidemiologic evidence suggests that exposure to ambient airborne PM2.5 increases risk of female infertility. However, relatively few studies have systematically explored harmful effect chronic on ovarian function and underlying mechanisms. In this study, C57BL/6J mice are exposed filtered air or urban for 4 months through a whole-body system. It is found significantly caused alteration estrus cycles, reproductivity, hormone levels, reserve. The granulosa cell apoptosis via mitochondria dependent pathway contributes follicle atresia. With RNA-sequencing technique, differentially expressed genes induced by mainly enriched in steroidogenesis, reactive oxygen species oxidative phosphorylation pathways. Furthermore, it increased profoundly exacerbated stress inflammation NF-κB/IL-6 signaling pathway. Notably, dietary polydatin (PD) supplement has protective against PM2.5-induced dysfunction.These striking findings demonstrate and/or critical factor dysfunction mitochondria-dependent NF-κB/IL-6-mediated pathway, PD may serve as pharmaceutic candidate pollution-associated dysfunction.

Язык: Английский

Процитировано

75