Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Май 20, 2024
Abstract
Tumor
biomarkers,
the
substances
which
are
produced
by
tumors
or
body’s
responses
to
during
tumorigenesis
and
progression,
have
been
demonstrated
possess
critical
encouraging
value
in
screening
early
diagnosis,
prognosis
prediction,
recurrence
detection,
therapeutic
efficacy
monitoring
of
cancers.
Over
past
decades,
continuous
progress
has
made
exploring
discovering
novel,
sensitive,
specific,
accurate
tumor
significantly
promoted
personalized
medicine
improved
outcomes
cancer
patients,
especially
advances
molecular
biology
technologies
developed
for
detection
biomarkers.
Herein,
we
summarize
discovery
development
including
history
conventional
innovative
used
biomarker
classification
biomarkers
based
on
tissue
origins,
application
clinical
management.
In
particular,
highlight
recent
advancements
biomarker-based
anticancer-targeted
therapies
emerging
as
breakthroughs
promising
strategies.
We
also
discuss
limitations
challenges
that
need
be
addressed
provide
insights
perspectives
turn
into
opportunities
this
field.
Collectively,
multiple
emphasized
review
may
guidance
precision
medicine,
broaden
horizons
future
research
directions,
expedite
patients
according
their
rather
than
organs
origin.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
60(42), С. 22624 - 22638
Опубликована: Авг. 12, 2020
There
has
been
much
interest
in
dual-emission
materials
the
past
few
years
for
and
life
science
applications;
however,
a
systematic
overview
of
underlying
processes
is
so-far
missing.
We
resolve
this
issue
herein
by
classifying
(DE)
phenomena
as
relying
on
one
emitter
with
two
emitting
states
(DE1),
independent
emitters
(DE2),
or
correlated
(DE3).
Relevant
DE
mechanisms
are
then
briefly
described
together
electronic
and/or
geometrical
conditions
under
which
they
occur.
For
further
reading,
references
given
that
offer
detailed
insight
into
complex
mechanistic
aspects
various
provide
overviews
families
their
applications.
By
avoiding
ambiguities
misinterpretations,
systematic,
insightful
Review
might
inspire
future
targeted
designs
materials.
Chemical Society Reviews,
Год журнала:
2019,
Номер
48(19), С. 5140 - 5176
Опубликована: Янв. 1, 2019
This
review
is
a
systematic
description
of
shape-dependent
effects
on
nanomaterials
from
theory,
synthesis,
property
to
application,
meanwhile,
elaborates
and
predicts
the
properties
applications
nanoparticles
with
diverse
morphologies
in
physicochemical
biomedical
fields.
Advanced Materials,
Год журнала:
2019,
Номер
31(49)
Опубликована: Сен. 19, 2019
Surgical
resection
is
the
primary
and
most
effective
treatment
for
patients
with
solid
tumors.
However,
suffer
from
postoperative
recurrence
metastasis.
In
past
years,
emerging
nanotechnology
has
led
way
to
minimally
invasive,
precision
intelligent
oncological
surgery
after
rapid
development
of
invasive
surgical
technology.
Advanced
in
construction
nanomaterials
(NMs)
imaging-guided
(IGS)
as
well
surgery-assisted
synergistic
therapy
summarized,
thereby
unlocking
advantages
multimodal
IGS-assisted
cancer
therapy.
First,
mechanisms
principles
NMs
targets
are
briefly
introduced.
Multimodal
imaging
based
on
molecular
technologies
provides
a
practical
method
achieve
intraoperative
visualization
high
resolution
deep
tissue
penetration.
Moreover,
multifunctional
synergize
adjuvant
(e.g.,
chemotherapy,
immunotherapy,
phototherapy)
eliminate
residual
lesions.
Finally,
key
issues
ideal
theranostic
associated
applications
challenges
clinical
transformation
discussed
push
forward
further
Chemical Society Reviews,
Год журнала:
2020,
Номер
49(3), С. 765 - 838
Опубликована: Янв. 1, 2020
Dinuclear
metal
complexes
have
enabled
breakthroughs
in
OLEDs,
photocatalytic
water
splitting
and
CO2reduction,
DSPEC,
chemosensors,
biosensors,
PDT
smart
materials.
Journal of the American Chemical Society,
Год журнала:
2019,
Номер
141(45), С. 17973 - 17977
Опубликована: Окт. 28, 2019
Tracking
signaling
H2S
in
live
mice
demands
responsive
imaging
with
fine
tissue
depth
and
low
interferences
from
scattering/autofluorescence
probe
concentration.
With
complementary
advantages
of
fluorescence
photoacoustic
(PA)
imaging,
optical/PA
dual-modality
was
suggested
for
in/ex
vivo
imaging.
Therefore,
a
meso-benzoyloxyltricarboheptamethine
cyanine,
HS-CyBz,
prepared
as
the
first
ratiometric
H2S,
profiting
keto–enol
transition
sensing
mechanism.
Tail
intravenous
injection
this
leads
to
accumulation
liver
mice,
endogenous
upregulation
triggered
by
S-adenosyl-l-methionine
has
been
verified
suggesting
promising
potential
Bioconjugate Chemistry,
Год журнала:
2020,
Номер
31(2), С. 276 - 292
Опубликована: Янв. 14, 2020
The
greatest
advantage
of
activatable
fluorescence
probes
(AFPs)
is
the
inherent
responsiveness
to
manipulate
spectroscopic
properties
by
chemical/physical
interactions
with
biological
analytes/microenvironmental
factors.
As
alternatives
"always-on"
probes,
AFPs
in
first
near-infrared
(NIR-I)
window
expanded
dramatically
over
past
decade
and
served
as
powerful
tools
biosensing
bioimaging.
Benefiting
from
deep
tissue
penetration,
minimal
damage,
negligible
background
signal
within
longer
wavelength,
recent
progress
fluorescent
materials
second
(NIR-II)
has
been
creating
vast
new
opportunities
developing
AFPs.
Here,
we
review
current
role
bioimaging,
emphasis
on
NIR-II
developed
for
biomedical
applications.
challenges
prospects
are
also
discussed
considering
clinical
translation
bench
bedside.
