Polyphenols: A concise overview on the chemistry, occurrence, and human health

Phytotherapy Research, Год журнала: 2019, Номер 33(9), С. 2221 - 2243

Опубликована: Июль 29, 2019

This review gives an updated picture of each class phenolic compounds and their properties. The most common classification implies the subdivision phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, isoflavones) non‐flavonoids acids, xanthones, stilbens, lignans, tannins) polyphenols. great interest polyphenols is associated with high potential application for food preservation therapeutic beneficial use. relationship between polyphenol intake human health has been exploited special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, cancer. use current existing databases bioactive including described as key tools research.

Язык: Английский

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Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Drug Design Development and Therapy, Год журнала: 2021, Номер Volume 15, С. 4503 - 4525

Опубликована: Ноя. 1, 2021

Abstract: Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has variety biological activities, among which anti-inflammatory effect significant feature it. Inflammation complex and pervasive physiological pathological process. The mechanisms inflammatory bowel disease, psoriasis, atherosclerosis, COVID-19 other research focus diseases are not clear yet, they considered to be related inflammation. can effectively improve the symptoms these expected candidate drug treatment diseases. This paper mainly reviews curcumin, mechanism diseases, regulatory on these, latest results improvement pharmacokinetics. It beneficial further study provides new ideas insights development preparations. Keywords: anti-inflammatory, osteoarthritis, atherosclerotic, pharmacokinetics, prodrug

Язык: Английский

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Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

Nutrients, Год журнала: 2018, Номер 10(10), С. 1553 - 1553

Опубликована: Окт. 19, 2018

Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which commonly used as spice in cooking and yellow pigment the food processing industry. Recent studies have demonstrated that curcumin has variety biological activities pharmacological performances, providing protection promotion human health. In addition to presenting an overview gut metabolism curcumin, this paper reviews current research progress on its versatile bioactivity, such antioxidant, anti-inflammatory, immune-regulatory activities, also intensively discusses health benefits, including protective or preventive effects cancers diabetes, well liver, nervous system, cardiovascular systems, highlighting potential molecular mechanisms. Besides, beneficial are further stated based clinical trials. Considering there still debate we discuss related challenges prospects. Overall, promising ingredient novel functional foods, with efficacy preventing certain diseases. We hope comprehensive updated review will be helpful for promoting human-based facilitate use diseases future.

Язык: Английский

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The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

International Journal of Molecular Sciences, Год журнала: 2018, Номер 19(9), С. 2729 - 2729

Опубликована: Сен. 12, 2018

Toll-like receptors (TLRs) are a well-known family of pattern recognition that play an important role in host immune system. TLR triggering leads to the induction pro-inflammatory cytokines and chemokines, driving activation both innate adaptive immunity. Recently, increasing number studies have shown link between TLRs cancer. Among them, toll-like receptor 4 (TLR4) signaling pathway is associated with inflammatory response cancer progression. Dietary phytochemicals potential modulators immunological status various pharmacological properties including anti-cancer, anti-oxidant anti-inflammatory. Curcumin, 6-gingerol, 6-shogaol, 1-dehydro-10-gingerdione, epigallocatechin gallate (EGCG), luteolin, quercetin, resveratrol, caffeic acid phenethyl ester, xanthohumol, genistein, berberine, sulforaphane can inhibit TLR4 activation. The aim present review describe We further introduce bioactive anti-inflammation chemoprevention by inhibiting

Язык: Английский

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Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

Molecules, Год журнала: 2020, Номер 25(6), С. 1397 - 1397

Опубликована: Март 19, 2020

Curcumin exerts a wide range of beneficial physiological and pharmacological activities, including antioxidant, anti-amyloid, anti-inflammatory, anti-microbial, anti-neoplastic, immune-modulating, metabolism regulating, anti-depressant, neuroprotective tissue protective effects. However, its poor solubility absorption in the free form gastrointestinal tract rapid biotransformation to inactive metabolites greatly limit utility as health-promoting agent dietary supplement. Recent advances micro- nano-formulations curcumin with enhanced resulting desirable blood levels active forms now make it possible address potential applications, pain management, protective. Using these highly bioavailable enable broad spectrum appropriate studies be conducted. This review discusses formulations designed enhance bioavailability, curcumin, relationships between particle size relative human pharmacokinetic involving formulated products, widely used but inappropriate practice hydrolyzing plasma samples for quantification current applications promising directions health maintenance applications.

Язык: Английский

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Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability

Journal of the Science of Food and Agriculture, Год журнала: 2021, Номер 101(14), С. 5747 - 5762

Опубликована: Июнь 18, 2021

Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as an aromatic stimulant, food preservative, coloring material. The commonly used names of turmeric are castor saffron, turmeric, saffron root. yellow-orange polyphenolic natural substance derived from C. rhizomes. It has been to treat common inflammatory diseases, tumors, biliary anorexia, cough, topical wounds, diabetic injuries, liver disorders, rheumatism, sinusitis. Extensive studies on the biological properties pharmacological consequences extracts have conducted recent years. Curcumin, primary yellow biocomponent anti-inflammatory, antioxidant, anticarcinogenic, antidiabetic, antibacterial, antiprotozoal, antiviral, antifibrotic, immunomodulatory, antifungal properties. Defense assessment tests showed that curcumin tolerated well at high doses, without adverse effects. Thus, highly active material with potential different diseases modern medicine. This review article focuses curcumin's characteristics. most popular methods for encapsulation also discussed. Several effective techniques approaches proposed curcuminoid capsulation, including nanocomplexing, gelation, complex coacervation, electrospraying, solvent-free pH-driven encapsulation. highlights chemical properties, allowing readers expand their perspectives its use development functional products health-promoting © 2021 Society Chemical Industry.

Язык: Английский

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Liposomes for Enhanced Bioavailability of Water-Insoluble Drugs: In Vivo Evidence and Recent Approaches

Pharmaceutics, Год журнала: 2020, Номер 12(3), С. 264 - 264

Опубликована: Март 13, 2020

It has been known that a considerable number of drugs in clinical use or under development are water-insoluble with poor bioavailability (BA). The liposomal delivery system drawn attention as one the noteworthy approaches to increase dissolution and subsequently absorption gastrointestinal (GI) tract because its biocompatibility ability encapsulate hydrophobic molecules lipid domain. However, there have several drawbacks, such structural instability GI permeability across intestinal epithelia relatively large size. In addition, no formulations approved for oral date, despite success parenteral liposomes. Nevertheless, resurged rapid published studies last decade. it is discouraging most this research vitro only not many vivo data. present review focused on evidence improved BA using liposomes resolve doubts raised concerning attempted provide insight by highlighting used achievements.

Язык: Английский

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Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Nutrients, Год журнала: 2020, Номер 12(9), С. 2499 - 2499

Опубликована: Авг. 19, 2020

Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries traditional Asian medicine, and nowadays it is widely food as dietary spice worldwide. It received considerable attention its pharmacological activities, which appear to act primarily through anti-inflammatory antioxidant mechanisms. For this reason, proposed tool management many diseases, among are gastrointestinal neurological diabetes, several types cancer. However, pharmacology curcumin remains be elucidated; indeed, discrepancy exists between well-documented vitro vivo activities poor bioavailability chemical instability that should limit any therapeutic effect. Recently, hypothesized could exert direct regulative effects tract, where high concentrations have detected after oral administration. Consequently, might directly exerts regulatory on gut microbiota, thus explaining paradox low systemic wide activities. well known microbiota important roles human physiology, composition can influenced by multitude environmental lifestyle factors. Accordingly, perturbations microbiome profile or dysbiosis key role disease progression. Interestingly, metabolites shown influence microbiota. worth noting from interaction two different phenomena arise: regulation intestinal microflora biotransformation both them potentially crucial activity. This review summarizes most recent studies topic, highlighting strong connection with final aim adding new insight into potential mechanisms effects.

Язык: Английский

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Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

Pharmaceutics, Год журнала: 2021, Номер 13(10), С. 1715 - 1715

Опубликована: Окт. 17, 2021

Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is also characterized by problematic drug delivery and scarce bioavailability, representing the main problem related to use this compound. Poor absorption, fast metabolism, rapid systemic clearance are most important factors contributing low curcumin levels in plasma tissues. Accordingly, overcome these issues, numerous strategies have been proposed investigated article. Due advances field, we describe here promising for increasing including adjuvant, complexed/encapsulated curcumin, specific formulations, nanoparticles. We analyze current strategies, already available market, advanced technologies that can offer future perspective effective formulations. focus attention on effectiveness curcumin-based formulations clinical trials, providing comprehensive summary. Clinical trial results, employing various methods showed improved bioavailability corresponds increased therapeutic efficacy. Furthermore, field nanoparticles hold great promise developing complexes as agents. Summarizing, suitable polyphenol will ensure possibility using curcumin-derived practice preventive disease-modifying therapeutics.

Язык: Английский

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Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy

Journal of Photochemistry and Photobiology C Photochemistry Reviews, Год журнала: 2020, Номер 45, С. 100384 - 100384

Опубликована: Сен. 9, 2020

Язык: Английский

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