Journal of Agricultural and Food Chemistry,
Год журнала:
2020,
Номер
68(39), С. 10489 - 10516
Опубликована: Авг. 26, 2020
Caffeoylquinic
acids
(CQAs)
are
a
broad
class
of
secondary
metabolites
that
have
been
found
in
edible
and
medicinal
plants
from
various
families.
It
has
100
years
since
the
discovery
chlorogenic
acid
1920.
In
recent
years,
number
naturally
derived
CQAs
isolated
structurally
elucidated.
Accumulated
evidence
demonstrate
wide
range
biological
activities,
such
as
antioxidation,
antibacterial,
antiparasitic,
neuroprotective,
anti-inflammatory,
anticancer,
antiviral,
antidiabetic
effects.
Up
to
date,
some
meaningful
progresses
on
biosynthesis
total
synthesis
also
made.
Therefore,
it
is
necessary
comprehensively
summarize
structure,
activity,
biosynthesis,
chemical
CQAs.
This
review
provides
extensive
coverage
occurring
discovered
1990
until
2020.
Modern
isolation
techniques,
data
(including
synthesis),
bioactivity
summarized.
would
be
helpful
for
further
research
potential
pharmaceutical
agents.
Phytotherapy Research,
Год журнала:
2019,
Номер
33(9), С. 2221 - 2243
Опубликована: Июль 29, 2019
This
review
gives
an
updated
picture
of
each
class
phenolic
compounds
and
their
properties.
The
most
common
classification
implies
the
subdivision
phenolics
in
two
main
groups:
flavonoids
(e.g.,
anthocyanins,
flavanols,
flavanones,
flavonols,
flavonones,
isoflavones)
non‐flavonoids
acids,
xanthones,
stilbens,
lignans,
tannins)
polyphenols.
great
interest
polyphenols
is
associated
with
high
potential
application
for
food
preservation
therapeutic
beneficial
use.
relationship
between
polyphenol
intake
human
health
has
been
exploited
special
reference
to
cardiovascular
diseases,
hypertension,
diabetes,
metabolic
syndrome,
obesity,
cancer.
use
current
existing
databases
bioactive
including
described
as
key
tools
research.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2018,
Номер
17(5), С. 1054 - 1112
Опубликована: Июль 10, 2018
Abstract
Flavonoids
are
plant‐derived
dietary
components
with
a
substantial
impact
on
human
health.
Research
has
expanded
massively
since
it
began
in
the
1930s,
and
complex
pathways
involved
bioavailability
of
flavonoids
body
now
well
understood.
In
recent
years,
been
appreciated
that
gut
microbiome
plays
major
role
flavonoid
action,
but
much
progress
still
needs
to
be
made
this
area.
Since
first
publications
health
effects
flavonoids,
their
action
is
understood
protect
against
various
stresses,
mechanism
evolved
from
debunked
simple
direct
antioxidant
hypothesis
into
an
understanding
molecular
targets
enzymes
specific
cell
types.
This
review
traces
development
field
over
past
8
decades,
indicates
current
state
art,
how
was
reached.
Future
recommendations
based
historical
analysis
(a)
focus
key
areas
(b)
perform
intervention
studies
focusing
protective
effects,
(c)
carry
out
cellular
vitro
experiments
using
appropriate
cells
together
chemical
form
found
at
site
action;
could
native
compounds
food
for
digestion
intestine,
conjugated
metabolites
blood
after
absorption
small
intestine
cells,
or
forms
tissues
catabolism
by
microbiota.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2020,
Номер
19(6), С. 3130 - 3158
Опубликована: Сен. 4, 2020
Abstract
Chlorogenic
acids
(CGAs),
a
group
of
hydroxycinnamates,
are
generally
abundant
in
everyday
foods
and
beverages,
most
prominently
certain
coffee
drinks.
Among
them,
the
chlorogenic
acid
(CGA),
also
termed
as
5‐
O
‐caffeoylquinic
(5‐CQA),
is
one
abundant,
highly
functional
polyphenolic
compounds
human
diet.
The
evidence
its
health
benefits
obtained
from
clinical
studies,
well
basic
research,
indicates
an
inverse
correlation
between
5‐CQA
consumption
lower
risk
metabolic
syndromes
chronic
diseases.
This
review
focuses
on
beneficial
properties
for
mechanisms
action
5‐CQA,
starting
with
history,
isomers,
dietary
sources,
processing
effects,
preparation
methods,
pharmacological
safety
evaluation,
bioavailability.
It
provides
possible
molecular
mechanistic
bases
to
explain
effects
including
neuroprotective,
cardiovascular
protective,
gastrointestinal
renoprotective,
hepatoprotective,
glucose
lipid
metabolism
regulatory,
anticarcinogenic
effects.
information
summarized
here
could
aid
research
natural
additive,
potential
drug
candidate,
promoter.
Antioxidants,
Год журнала:
2021,
Номер
10(2), С. 188 - 188
Опубликована: Янв. 28, 2021
This
review
presents
the
comprehensive
knowledge
about
bidirectional
relationship
between
polyphenols
and
gut
microbiome.
The
first
part
is
related
to
polyphenols’
impacts
on
various
microorganisms,
especially
bacteria,
their
influence
intestinal
pathogens.
research
data
mechanisms
of
polyphenol
action
were
collected
together
organized.
impact
groups
bacteria
both
whole
“microbiota”
particular
species,
including
probiotics,
are
presented.
Moreover,
present
in
food
(bound
matrix)
was
compared
with
purified
(such
as
dietary
supplements)
well
form
derivatives
glycosides)
those
aglycones.
second
paper
discusses
detail
(pathways)
role
bacterial
biotransformation
most
important
polyphenols,
production
bioactive
metabolites
a
significant
human
organism
(both
positive
negative).
Food Frontiers,
Год журнала:
2020,
Номер
1(1), С. 18 - 44
Опубликована: Март 1, 2020
Abstract
Dietary
polyphenols
have
been
widely
investigated
as
antidiabetic
agents
in
cell,
animals,
human
study,
and
clinical
trial.
The
number
of
publication
(Indexed
by
Web
Science)
on
“polyphenols
diabetes”
significantly
increased
since
2010.
This
review
highlights
the
advances
opportunities
dietary
agents.
prevent
manage
Type
2
diabetes
mellitus
via
insulin‐dependent
approaches,
for
instance,
protection
pancreatic
islet
β‐cell,
reduction
β‐cell
apoptosis,
promotion
proliferation,
attenuation
oxidative
stress,
activation
insulin
signaling,
stimulation
pancreas
to
secrete
insulin,
well
insulin‐independent
approaches
including
inhibition
glucose
absorption,
digestive
enzymes,
regulation
intestinal
microbiota,
modification
inflammation
response,
formation
advanced
glycation
end
products.
Moreover,
ameliorate
diabetic
complications,
such
vascular
dysfunction,
nephropathy,
retinopathy,
neuropathy,
cardiomyopathy,
coronary
diseases,
renal
failure,
so
on.
structure–activity
relationship
is
still
not
clear.
individual
flavonoid
or
isoflavone
has
no
therapeutic
effect
patients,
although
data
are
very
limited.
Resveratrol,
curcumin,
anthocyanins
showed
activity
study.
How
hyperglycemia
influences
bioavailability
bioactivity
understood.
An
understanding
how
alters
will
lead
an
improvement
their
benefits
outcomes.
Molecular Nutrition & Food Research,
Год журнала:
2020,
Номер
64(9)
Опубликована: Март 20, 2020
Abstract
The
full
consensus
on
the
role
of
dietary
polyphenols
as
human‐health‐promoting
compounds
remains
elusive.
two‐way
interaction
between
and
gut
microbiota
(GM)
(i.e.,
modulation
GM
by
their
catabolism
GM)
is
determinant
in
polyphenols’
effects.
identification
human
metabotypes
associated
with
a
differential
microbial
metabolism
has
opened
new
research
scenarios
to
explain
inter‐individual
variability
upon
consumption.
unequivocally
identified
so
far
are
those
involved
isoflavones
(equol
and(or)
O
‐desmethylangolesin
producers
versus
non‐producers)
ellagic
acid
(urolithin
metabotypes,
including
only
urolithin‐A
(UM‐A),
urolithin‐A,
isourolithin‐A,
urolithin‐B
(UM‐B),
non‐producers
(UM‐0)).
In
addition,
metabolites
(phenolic‐derived
postbiotics)
such
equol,
urolithins,
valerolactones,
enterolactone,
enterodiol,
8‐prenylnaringenin,
among
others,
can
exert
health
knowledge
updated
position
taken
here
i)
polyphenols,
ii)
evidence
phenolic‐derived
postbiotics
health,
iii)
biomarkers
clustering
individuals
depending
(metabotyping)
effects,
iv)
catecholamines
illustrate
intersection
personalized
nutrition
precision
medicine.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
22(1), С. 107 - 107
Опубликована: Дек. 24, 2020
Coffee
is
one
of
the
most
widely
consumed
beverages
worldwide.
It
usually
identified
as
a
stimulant
because
high
content
caffeine.
However,
caffeine
not
only
coffee
bioactive
component.
The
beverage
in
fact
mixture
number
compounds
such
polyphenols,
especially
chlorogenic
acids
(in
green
beans)
and
caffeic
acid
roasted
beans),
alkaloids
(caffeine
trigonelline),
diterpenes
(cafestol
kahweol).
Extensive
research
shows
that
consumption
appears
to
have
beneficial
effects
on
human
health.
Regular
intake
may
protect
from
many
chronic
disorders,
including
cardiovascular
disease,
type
2
diabetes,
obesity,
some
types
cancer.
Importantly,
seems
be
also
correlated
with
decreased
risk
developing
neurodegenerative
conditions
Alzheimer’s
Parkinson’s
dementia.
reduce
stroke.
mechanism
underlying
these
is,
however,
still
poorly
understood.
This
review
summarizes
current
knowledge
neuroprotective
potential
main
components,
i.e.,
caffeine,
acid,
trigonelline,
kahweol,
cafestol.
Data
both
vitro
vivo
preclinical
experiments,
their
therapeutic
applications,
are
reviewed
discussed.
Epidemiological
studies
clinical
reports
this
matter
described.
Moreover,
molecular
mechanism(s)
by
which
components
provide
neuroprotection
reviewed.
Nutrients,
Год журнала:
2020,
Номер
12(8), С. 2190 - 2190
Опубликована: Июль 23, 2020
Hydroxycinnamic
acids
(HCAs)
are
important
natural
phenolic
compounds
present
in
high
concentrations
fruits,
vegetables,
cereals,
coffee,
tea
and
wine.
Many
health
beneficial
effects
have
been
acknowledged
food
products
rich
HCAs;
however,
processing,
dietary
intake,
bioaccessibility
pharmacokinetics
a
impact
on
HCAs
to
reach
the
target
tissue
order
exert
their
biological
activities.
In
particular,
metabolism
is
of
importance
since
HCAs’
metabolites
could
either
lose
activity
or
be
even
more
potent
compared
parent
compounds.
this
review,
sources
pharmacokinetic
properties
esters
presented
discussed.
The
main
focus
along
with
activities
benefits.
Special
emphasis
given
specific
comparison
The Plant Journal,
Год журнала:
2021,
Номер
107(5), С. 1299 - 1319
Опубликована: Июнь 25, 2021
Caffeoylquinic
acids
(CQAs)
are
specialized
plant
metabolites
we
encounter
in
our
daily
life.
Humans
consume
CQAs
mg-to-gram
quantities
through
dietary
consumption
of
products.
considered
beneficial
for
human
health,
mainly
due
to
their
anti-inflammatory
and
antioxidant
properties.
Recently,
new
biosynthetic
pathways
via
a
peroxidase-type
p-coumaric
acid
3-hydroxylase
enzyme
were
discovered.
More
recently,
GDSL
lipase-like
able
transform
monoCQAs
into
diCQA
was
identified
Ipomoea
batatas.
recently
linked
memory
improvement;
they
seem
be
strong
indirect
antioxidants
Nrf2
activation.
However,
there
is
prevalent
confusion
the
designation
nomenclature
different
CQA
isomers.
Such
inconsistencies
critical
complicate
bioactivity
assessment
since
isomers
differ
potency.
A
detailed
explanation
regarding
origin
such
provided,
recommendation
unify
suggested.
Furthermore,
studies
on
bioactivity,
plant-based
laboratory
animal
diets
contain
CQAs,
which
makes
it
difficult
include
proper
control
groups
comparison.
Therefore,
synthetic
diet
free
advised
avoid
interferences
some
may
produce
even
at
nanomolar
levels.
Biotransformation
by
gut
microbiota,
discovery
enzymatic
metabolic
pathways,
assessment,
biological
properties
with
potential
drug
development
areas
active,
ongoing
research.
This
review
focused
chemistry,
biosynthesis,
occurrence,
analytical
challenges,
reported
mono-,
di-,
tri-,
tetraCQAs.