Polyphenols: A concise overview on the chemistry, occurrence, and human health

Phytotherapy Research, Год журнала: 2019, Номер 33(9), С. 2221 - 2243

Опубликована: Июль 29, 2019

This review gives an updated picture of each class phenolic compounds and their properties. The most common classification implies the subdivision phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, isoflavones) non‐flavonoids acids, xanthones, stilbens, lignans, tannins) polyphenols. great interest polyphenols is associated with high potential application for food preservation therapeutic beneficial use. relationship between polyphenol intake human health has been exploited special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, cancer. use current existing databases bioactive including described as key tools research.

Язык: Английский

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The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2018, Номер 17(5), С. 1054 - 1112

Опубликована: Июль 10, 2018

Abstract Flavonoids are plant‐derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and complex pathways involved bioavailability of flavonoids body now well understood. In recent years, been appreciated that gut microbiome plays major role flavonoid action, but much progress still needs to be made this area. Since first publications health effects flavonoids, their action is understood protect against various stresses, mechanism evolved from debunked simple direct antioxidant hypothesis into an understanding molecular targets enzymes specific cell types. This review traces development field over past 8 decades, indicates current state art, how was reached. Future recommendations based historical analysis (a) focus key areas (b) perform intervention studies focusing protective effects, (c) carry out cellular vitro experiments using appropriate cells together chemical form found at site action; could native compounds food for digestion intestine, conjugated metabolites blood after absorption small intestine cells, or forms tissues catabolism by microbiota.

Язык: Английский

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Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2020, Номер 19(6), С. 3130 - 3158

Опубликована: Сен. 4, 2020

Abstract Chlorogenic acids (CGAs), a group of hydroxycinnamates, are generally abundant in everyday foods and beverages, most prominently certain coffee drinks. Among them, the chlorogenic acid (CGA), also termed as 5‐ O ‐caffeoylquinic (5‐CQA), is one abundant, highly functional polyphenolic compounds human diet. The evidence its health benefits obtained from clinical studies, well basic research, indicates an inverse correlation between 5‐CQA consumption lower risk metabolic syndromes chronic diseases. This review focuses on beneficial properties for mechanisms action 5‐CQA, starting with history, isomers, dietary sources, processing effects, preparation methods, pharmacological safety evaluation, bioavailability. It provides possible molecular mechanistic bases to explain effects including neuroprotective, cardiovascular protective, gastrointestinal renoprotective, hepatoprotective, glucose lipid metabolism regulatory, anticarcinogenic effects. information summarized here could aid research natural additive, potential drug candidate, promoter.

Язык: Английский

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The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota

Antioxidants, Год журнала: 2021, Номер 10(2), С. 188 - 188

Опубликована: Янв. 28, 2021

This review presents the comprehensive knowledge about bidirectional relationship between polyphenols and gut microbiome. The first part is related to polyphenols’ impacts on various microorganisms, especially bacteria, their influence intestinal pathogens. research data mechanisms of polyphenol action were collected together organized. impact groups bacteria both whole “microbiota” particular species, including probiotics, are presented. Moreover, present in food (bound matrix) was compared with purified (such as dietary supplements) well form derivatives glycosides) those aglycones. second paper discusses detail (pathways) role bacterial biotransformation most important polyphenols, production bioactive metabolites a significant human organism (both positive negative).

Язык: Английский

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Dietary polyphenols as antidiabetic agents: Advances and opportunities

Food Frontiers, Год журнала: 2020, Номер 1(1), С. 18 - 44

Опубликована: Март 1, 2020

Abstract Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web Science) on “polyphenols diabetes” significantly increased since 2010. This review highlights the advances opportunities dietary agents. prevent manage Type 2 diabetes mellitus via insulin‐dependent approaches, for instance, protection pancreatic islet β‐cell, reduction β‐cell apoptosis, promotion proliferation, attenuation oxidative stress, activation insulin signaling, stimulation pancreas to secrete insulin, well insulin‐independent approaches including inhibition glucose absorption, digestive enzymes, regulation intestinal microbiota, modification inflammation response, formation advanced glycation end products. Moreover, ameliorate diabetic complications, such vascular dysfunction, nephropathy, retinopathy, neuropathy, cardiomyopathy, coronary diseases, renal failure, so on. structure–activity relationship is still not clear. individual flavonoid or isoflavone has no therapeutic effect patients, although data are very limited. Resveratrol, curcumin, anthocyanins showed activity study. How hyperglycemia influences bioavailability bioactivity understood. An understanding how alters will lead an improvement their benefits outcomes.

Язык: Английский

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Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Molecular Nutrition & Food Research, Год журнала: 2020, Номер 64(9)

Опубликована: Март 20, 2020

Abstract The full consensus on the role of dietary polyphenols as human‐health‐promoting compounds remains elusive. two‐way interaction between and gut microbiota (GM) (i.e., modulation GM by their catabolism GM) is determinant in polyphenols’ effects. identification human metabotypes associated with a differential microbial metabolism has opened new research scenarios to explain inter‐individual variability upon consumption. unequivocally identified so far are those involved isoflavones (equol and(or) O ‐desmethylangolesin producers versus non‐producers) ellagic acid (urolithin metabotypes, including only urolithin‐A (UM‐A), urolithin‐A, isourolithin‐A, urolithin‐B (UM‐B), non‐producers (UM‐0)). In addition, metabolites (phenolic‐derived postbiotics) such equol, urolithins, valerolactones, enterolactone, enterodiol, 8‐prenylnaringenin, among others, can exert health knowledge updated position taken here i) polyphenols, ii) evidence phenolic‐derived postbiotics health, iii) biomarkers clustering individuals depending (metabotyping) effects, iv) catecholamines illustrate intersection personalized nutrition precision medicine.

Язык: Английский

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Neuroprotective Effects of Coffee Bioactive Compounds: A Review

International Journal of Molecular Sciences, Год журнала: 2020, Номер 22(1), С. 107 - 107

Опубликована: Дек. 24, 2020

Coffee is one of the most widely consumed beverages worldwide. It usually identified as a stimulant because high content caffeine. However, caffeine not only coffee bioactive component. The beverage in fact mixture number compounds such polyphenols, especially chlorogenic acids (in green beans) and caffeic acid roasted beans), alkaloids (caffeine trigonelline), diterpenes (cafestol kahweol). Extensive research shows that consumption appears to have beneficial effects on human health. Regular intake may protect from many chronic disorders, including cardiovascular disease, type 2 diabetes, obesity, some types cancer. Importantly, seems be also correlated with decreased risk developing neurodegenerative conditions Alzheimer’s Parkinson’s dementia. reduce stroke. mechanism underlying these is, however, still poorly understood. This review summarizes current knowledge neuroprotective potential main components, i.e., caffeine, acid, trigonelline, kahweol, cafestol. Data both vitro vivo preclinical experiments, their therapeutic applications, are reviewed discussed. Epidemiological studies clinical reports this matter described. Moreover, molecular mechanism(s) by which components provide neuroprotection reviewed.

Язык: Английский

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Antibacterial and antioxidant activities for natural and synthetic dual-active compounds

European Journal of Medicinal Chemistry, Год журнала: 2018, Номер 158, С. 91 - 105

Опубликована: Сен. 5, 2018

Язык: Английский

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Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites

Nutrients, Год журнала: 2020, Номер 12(8), С. 2190 - 2190

Опубликована: Июль 23, 2020

Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged food products rich HCAs; however, processing, dietary intake, bioaccessibility pharmacokinetics a impact on HCAs to reach the target tissue order exert their biological activities. In particular, metabolism is of importance since HCAs’ metabolites could either lose activity or be even more potent compared parent compounds. this review, sources pharmacokinetic properties esters presented discussed. The main focus along with activities benefits. Special emphasis given specific comparison

Язык: Английский

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Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

The Plant Journal, Год журнала: 2021, Номер 107(5), С. 1299 - 1319

Опубликована: Июнь 25, 2021

Caffeoylquinic acids (CQAs) are specialized plant metabolites we encounter in our daily life. Humans consume CQAs mg-to-gram quantities through dietary consumption of products. considered beneficial for human health, mainly due to their anti-inflammatory and antioxidant properties. Recently, new biosynthetic pathways via a peroxidase-type p-coumaric acid 3-hydroxylase enzyme were discovered. More recently, GDSL lipase-like able transform monoCQAs into diCQA was identified Ipomoea batatas. recently linked memory improvement; they seem be strong indirect antioxidants Nrf2 activation. However, there is prevalent confusion the designation nomenclature different CQA isomers. Such inconsistencies critical complicate bioactivity assessment since isomers differ potency. A detailed explanation regarding origin such provided, recommendation unify suggested. Furthermore, studies on bioactivity, plant-based laboratory animal diets contain CQAs, which makes it difficult include proper control groups comparison. Therefore, synthetic diet free advised avoid interferences some may produce even at nanomolar levels. Biotransformation by gut microbiota, discovery enzymatic metabolic pathways, assessment, biological properties with potential drug development areas active, ongoing research. This review focused chemistry, biosynthesis, occurrence, analytical challenges, reported mono-, di-, tri-, tetraCQAs.

Язык: Английский

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