Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Март 10, 2022

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA its derivatives have been used for many centuries due to their natural healing medicinal properties. possesses various biological pharmacological activities, including antioxidant, anti-inflammatory, anticancer, neuroprotective effects. The potential therapeutic effects of are mediated via repression inhibition transcription growth factors. anticancer human cell cultures animal models. However, the biomolecular interactions pathways described highlighting target binding proteins signaling molecules. current review focuses on CA’s chemical, physical, properties, We further characteristics future directions.

Язык: Английский

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Dietary Anti-Aging Polyphenols and Potential Mechanisms

Antioxidants, Год журнала: 2021, Номер 10(2), С. 283 - 283

Опубликована: Фев. 13, 2021

For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, decreasing morbidities. With assistance basic research investigating potential mechanisms, it become clear that beneficial effects plant-based foods are mainly due to large amount bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies humans have supported supplementation polyphenols various health-promoting effects, especially elderly population. In vitro examinations on anti-aging mechanisms widely performed, using different types natural synthetic compounds. The aim this review is critically evaluate experimental evidence demonstrating aging-related diseases. We highlight polyphenols, including antioxidant signaling, preventing cellular senescence, targeting microRNA, influencing NO bioavailability, promoting mitochondrial function. While trends utilizing disorders getting growing attention, we suggest exploration combination multiple or polyphenol-rich foods, as would be more physiologically relevant daily life.

Язык: Английский

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Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Cell Death and Disease, Год журнала: 2023, Номер 14(2)

Опубликована: Фев. 16, 2023

Abstract The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in cardiovascular due its key contribution detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous investigations have suggested that disruption GSH a critical element pathogenesis myocardial injury. Meanwhile, newly proposed type cell death, ferroptosis, has been demonstrated closely related system, which affects process outcome Moreover, facing various pathological challenges, mammalian heart, possesses high levels mitochondria weak capacity, susceptible oxidant production oxidative damage. Therefore, targeted enhancement along with prevention ferroptosis myocardium promising therapeutic strategy. In this review, we first systematically describe physiological functions anabolism as well effects on cardiac Then, discuss relationship between comprehensive summary activation strategies presented, where mainly identify several herbal monomers, may provide valuable guidelines for exploration new approaches.

Язык: Английский

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Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

Metabolites, Год журнала: 2022, Номер 12(1), С. 50 - 50

Опубликована: Янв. 8, 2022

The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning of organism, affecting health disease status individuals. There continuous bidirectional communication between host, conforming to unique entity known as “holobiont”. Among these crosstalk mechanisms, synthesizes broad spectrum bioactive compounds or metabolites which exert pleiotropic effects on human organism. Many microbial can cross blood–brain barrier (BBB) have significant brain, playing key role in so-called microbiota-gut-brain axis. An altered (MGB) axis major characteristic many neuropsychiatric disorders, including depressive disorder (MDD). Significative differences eubiosis dysbiosis mental disorders like MDD with their different metabolite composition concentrations are being discussed. In present review, main (short-chain fatty acids -SCFAs-, bile acids, amino tryptophan -trp- derivatives, more), signaling pathways functions will be summarized explain part pathophysiology. Conclusions from promising translational approaches related metabolome addressed more depth discuss possible clinical value management patients.

Язык: Английский

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Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Nutrients, Год журнала: 2024, Номер 16(7), С. 924 - 924

Опубликована: Март 23, 2024

Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects response to variety pathological challenges, particularly conditions associated with chronic metabolic diseases and age-related disorders. It shows multidimensional functions, including neuroprotection for neurodegenerative disorders diabetic peripheral neuropathy, anti-inflammation, anti-oxidation, anti-pathogens, mitigation cardiovascular disorders, skin diseases, diabetes mellitus, liver kidney injuries, anti-tumor activities. Mechanistically, its integrative functions act through the modulation anti-inflammation/oxidation homeostasis. can thwart inflammatory constituents at multiple levels curtailing NF-kB pathways neutralize primitive factors, hindering propagation, alleviating inflammation-related tissue injury. concurrently raises pivotal antioxidants by activating Nrf2 pathway, thus scavenging excessive cellular free radicals. elevates AMPK maintenance restoration homeostasis glucose lipids. Additionally, neuromodulation targeting neuroreceptors ion channels. In this review, we systematically recapitulate CGA’s pharmacological activities, medicinal properties, mechanistic actions potential agent. Further studies defining specific molecules, improving bioavailability, validating clinical efficacy are required corroborate CGA.

Язык: Английский

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Dietary Phenolic Compounds: Their Health Benefits and Association with the Gut Microbiota

Antioxidants, Год журнала: 2023, Номер 12(4), С. 880 - 880

Опубликована: Апрель 4, 2023

Oxidative stress causes various diseases, such as type II diabetes and dyslipidemia, while antioxidants in foods may prevent a number of diseases delay aging by exerting their effects vivo. Phenolic compounds are phytochemicals flavonoids which consist flavonols, flavones, flavanonols, flavanones, anthocyanidins, isoflavones, lignans, stilbenoids, curcuminoids, phenolic acids, tannins. They have hydroxyl groups molecular structures. These present most plants, abundant nature, contribute to the bitterness color foods. Dietary compounds, quercetin onions sesamin sesame, exhibit antioxidant activity help cell diseases. In addition, other kinds tannins, larger weights, many unexplained aspects still exist. The activities be beneficial for human health. On hand, metabolism intestinal bacteria changes structures these with properties, resulting metabolites exert recent years, it has become possible analyze composition microbiota. augmentation microbiota intake been implicated disease prevention symptom recovery. Furthermore, "brain-gut axis", is communication system between gut microbiome brain, attracting increasing attention, research revealed that dietary affect brain homeostasis. this review, we discuss usefulness against some biotransformation microbiota, microflora, on brain-gut axis.

Язык: Английский

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Risk Assessment of Trigonelline in Coffee and Coffee By-Products

Molecules, Год журнала: 2023, Номер 28(8), С. 3460 - 3460

Опубликована: Апрель 14, 2023

Trigonelline is a bioactive pyridine alkaloid that occurs naturally in high concentrations coffee (up to 7.2 g/kg) and by-products 62.6 such as leaves, flowers, cherry husks or pulp, parchment, silver skin, spent grounds. In the past, were mostly considered waste discarded. recent years, however, use of food has attracted interest because their economic nutritional value environmental benefits sustainable resource use. Their authorization so-called novel foods European Union may lead increased oral exposure general population trigonelline. Therefore, aim this review was assess risk human health acute chronic trigonelline from by-products. An electronic literature search performed. Current toxicological knowledge limited, with few data available lack epidemiological clinical studies. There no evidence adverse effects after exposure. No conclusion can be drawn on isolated due data. However, ingested component appears safe for health, based traditional these products.

Язык: Английский

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Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence

Metabolites, Год журнала: 2025, Номер 15(2), С. 124 - 124

Опубликована: Фев. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Язык: Английский

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Relationship between the Chemical Composition and the Biological Functions of Coffee

Molecules, Год журнала: 2021, Номер 26(24), С. 7634 - 7634

Опубликована: Дек. 16, 2021

Coffee is a Rubiaceae coffee plant ranked as the first of three most important beverages in world, with effects including lowering blood sugar, protecting liver, and nerves. contains many chemical components, alkaloids, phenolic acids, flavonoids, terpenoids, so on. Chemical components are basis its biological function taste. The activities form characteristic aroma coffee. main have been extensively studied, which would provide relevant theoretical support for further development industry.

Язык: Английский

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Oxidative Stress and Cognitive Decline: The Neuroprotective Role of Natural Antioxidants

Frontiers in Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Окт. 13, 2021

Free- radicals (Oxygen and Nitrogen species) are formed in mitochondria during the oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads an increase of stress. This condition affects above all brain, that usually needs a large oxygen amount which there is major possibility accumulate “Reacting Species.” Antioxidant molecules fundamental limiting free-radical damage, particular central nervous system: stress, fact, seems worsen course neurodegenerative diseases. The aim this review sum up natural antioxidant with greatest neuroprotective properties against free radical genesis, understanding their relationship Central Nervous System.

Язык: Английский

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