Journal of Agricultural and Food Chemistry,
Год журнала:
2020,
Номер
68(39), С. 10489 - 10516
Опубликована: Авг. 26, 2020
Caffeoylquinic
acids
(CQAs)
are
a
broad
class
of
secondary
metabolites
that
have
been
found
in
edible
and
medicinal
plants
from
various
families.
It
has
100
years
since
the
discovery
chlorogenic
acid
1920.
In
recent
years,
number
naturally
derived
CQAs
isolated
structurally
elucidated.
Accumulated
evidence
demonstrate
wide
range
biological
activities,
such
as
antioxidation,
antibacterial,
antiparasitic,
neuroprotective,
anti-inflammatory,
anticancer,
antiviral,
antidiabetic
effects.
Up
to
date,
some
meaningful
progresses
on
biosynthesis
total
synthesis
also
made.
Therefore,
it
is
necessary
comprehensively
summarize
structure,
activity,
biosynthesis,
chemical
CQAs.
This
review
provides
extensive
coverage
occurring
discovered
1990
until
2020.
Modern
isolation
techniques,
data
(including
synthesis),
bioactivity
summarized.
would
be
helpful
for
further
research
potential
pharmaceutical
agents.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2020,
Номер
19(4), С. 1299 - 1352
Опубликована: Янв. 3, 2020
Acyl-quinic
acids
(chlorogenic
acids)
are
produced
by
many
plants,
including
fruits,
vegetables,
and
herbal
remedies,
with
coffee
maté
particularly
rich
dietary
sources.
Epidemiological
intervention
studies
suggest
that
they
can
reduce
the
risk
of
developing
type
2
diabetes
cardiovascular
disease.
This
review
addresses
their
metabolic
handling
after
oral
consumption
to
provide
a
mechanistic
basis
explain
possible
effects
on
health.
Intact
acyl-quinic
absorbed
only
small
extent
in
intestine,
but
cinnamic
efficiently
hydrolysis
either
digestive
or
microbial
enzymes
colon.
Metabolism
results
phenolic
conjugates
blood
urine,
varying
dependent
acid,
subject
significant
interperson
variability.
The
balance
between
hydrogenation
complete
β-oxidation
acids,
both
liver
gut
microbiota,
determines
profile
metabolites.
Pharmacokinetic
data
some
metabolites
bound
human
serum
albumin
and/or
sequestered
tissues,
exhibit
biological
activity
vitro,
consistent
proposed
protective
action
vivo.
Significant
gaps
literature
include
lack
plasma
urinary
for
free-living
individuals,
pharmacokinetic
groups
who
consume
at
regular
short
intervals.
Data
required
cis
isomers.
There
is
critical
need
precise
biomarkers
accounting
variability
individual
metabolism
beverage
composition,
thus
facilitating
better
translation
metabolite
measurements
into
accurate
improve
outcomes
future
epidemiological
studies.
Phytochemistry Reviews,
Год журнала:
2018,
Номер
18(1), С. 273 - 302
Опубликована: Окт. 10, 2018
Chlorogenic
acids
(CQAs),
the
esters
of
caffeic
and
quinic
acid,
are
biologically
important
phenolic
compounds
present
in
many
plant
species.
Nowadays
knowledge
about
their
pro-health
properties
including
anti-cancer
activity
is
great.
Yet
supposition
that
they
may
be
helpful
fighting
obesity
modify
glucose-6-phosphatase
involved
glucose
metabolism
has
led
to
some
revival
research
on
CQAs
natural
occurrence.
Considering
growing
interest
products
rich
CQAs,
it
not
surprising
more
efficient
extraction
methods,
leading
obtained
extracts
with
increased
content,
currently
being
sought.
It
worth
mentioning
here
this
task
very
easy
since
these
readily
degrade/transform
others.
Much
attention
also
paid
proper
analysis
content
plants
due
fact
main
representative
nature
i.e.
5-O-caffeoylquinic
acid
(5-CQA)
commonly
employed
as
a
marker
quality
control
various
products.
structural
similarity
instability,
number
commercially
available
standards
limited
just
few,
correct
another
challenge
should
faced.
The
aim
review
summarize
recent
advances
chemical
chlorogenic
acids,
sources,
properties,
methods
have
been
developed
improve
analysis,
special
5-CQA
compound
family
beneficial
effects
human
health.
Journal of Agricultural and Food Chemistry,
Год журнала:
2020,
Номер
68(39), С. 10489 - 10516
Опубликована: Авг. 26, 2020
Caffeoylquinic
acids
(CQAs)
are
a
broad
class
of
secondary
metabolites
that
have
been
found
in
edible
and
medicinal
plants
from
various
families.
It
has
100
years
since
the
discovery
chlorogenic
acid
1920.
In
recent
years,
number
naturally
derived
CQAs
isolated
structurally
elucidated.
Accumulated
evidence
demonstrate
wide
range
biological
activities,
such
as
antioxidation,
antibacterial,
antiparasitic,
neuroprotective,
anti-inflammatory,
anticancer,
antiviral,
antidiabetic
effects.
Up
to
date,
some
meaningful
progresses
on
biosynthesis
total
synthesis
also
made.
Therefore,
it
is
necessary
comprehensively
summarize
structure,
activity,
biosynthesis,
chemical
CQAs.
This
review
provides
extensive
coverage
occurring
discovered
1990
until
2020.
Modern
isolation
techniques,
data
(including
synthesis),
bioactivity
summarized.
would
be
helpful
for
further
research
potential
pharmaceutical
agents.
