Plants, Год журнала: 2024, Номер 13(16), С. 2309 - 2309
Опубликована: Авг. 20, 2024
Plant-growth-promoting bacteria (PGPB) have beneficial effects on plants. They can promote growth and enhance plant defense against abiotic stress disease, these are associated with changes in the metabolite profile. The research problem addressed this study was impact of inoculation PGPB profile
Язык: Английский
The Plant Journal, Год журнала: 2021, Номер 107(5), С. 1299 - 1319
Опубликована: Июнь 25, 2021
Caffeoylquinic acids (CQAs) are specialized plant metabolites we encounter in our daily life. Humans consume CQAs mg-to-gram quantities through dietary consumption of products. considered beneficial for human health, mainly due to their anti-inflammatory and antioxidant properties. Recently, new biosynthetic pathways via a peroxidase-type p-coumaric acid 3-hydroxylase enzyme were discovered. More recently, GDSL lipase-like able transform monoCQAs into diCQA was identified Ipomoea batatas. recently linked memory improvement; they seem be strong indirect antioxidants Nrf2 activation. However, there is prevalent confusion the designation nomenclature different CQA isomers. Such inconsistencies critical complicate bioactivity assessment since isomers differ potency. A detailed explanation regarding origin such provided, recommendation unify suggested. Furthermore, studies on bioactivity, plant-based laboratory animal diets contain CQAs, which makes it difficult include proper control groups comparison. Therefore, synthetic diet free advised avoid interferences some may produce even at nanomolar levels. Biotransformation by gut microbiota, discovery enzymatic metabolic pathways, assessment, biological properties with potential drug development areas active, ongoing research. This review focused chemistry, biosynthesis, occurrence, analytical challenges, reported mono-, di-, tri-, tetraCQAs.
Язык: Английский
Процитировано
182
Molecules, Год журнала: 2022, Номер 27(11), С. 3400 - 3400
Опубликована: Май 25, 2022
The demand of foods with high antioxidant capacity have increased and research on these continues to grow. This review is focused chlorogenic acids (CGAs) from green coffee, which the most abundant source. main CGA in coffee 5-O-caffeoylquinic acid (5-CQA). Coffee extracts are currently widely used source enhance activity foods. Due solubility CGAs, their extraction mainly performed organic solvents. CGAs been associated health benefits, such as antioxidant, antiviral, antibacterial, anticancer, anti-inflammatory activity, others that reduce risk cardiovascular diseases, type 2 diabetes, Alzheimer’s disease. However, biological activities depend stability sensitive pH, temperature, light. 5-CQA attributed reducing proinflammatory cytokines. can negatively affect colon microbiota. An increase anthocyanins was observed when were added different food matrices dairy products, drinks, chocolate, bakery products. fortification has potential improve functionality
Язык: Английский
Процитировано
78
Molecules, Год журнала: 2023, Номер 28(14), С. 5540 - 5540
Опубликована: Июль 20, 2023
Chlorogenic and isochlorogenic acids are naturally occurring antioxidant dietary polyphenolic compounds found in high concentrations plants, fruits, vegetables, coffee, coffee by-products. The objective of this review was to assess the potential health risks associated with oral consumption by-products containing chlorogenic acids, considering both acute chronic exposure. An electronic literature search conducted, revealing that 5-caffeoylquinic acid (5-CQA) 3,5-dicaffeoylquinic (3,5-DCQA) major Toxicological, pharmacokinetic, clinical data from animal human studies were available for assessment, which indicated no significant evidence toxic or adverse effects following current state knowledge suggests long-term exposure by daily does not appear pose a risk when observed at doses within normal range As result, intake CQAs can be considered reasonably safe.
Язык: Английский
Процитировано
27
Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 355 - 355
Опубликована: Март 9, 2024
The methods and solvents employed in routine extraction protocols essentially impact the composition of resulting extracts, i.e., relative abundances individual biologically active metabolites quality stability isolates. Natural deep eutectic (NADESs) represent a new class environmentally friendly solvents, which are recognized as promising extractants alternative to conventional organic liquids. However, their efficiencies when applied different workflows still poorly characterized. Therefore, here, we compare potential three for natural products from Aralia elata var. mandshurica with selected using non-targeted metabolomics approach. metabolite profiling relied on reversed-phase ultra-high-performance liquid chromatography–high-resolution mass spectrometry (RP-UHPLC-HR-MS). roots A. were extracted by maceration, ultrasound-assisted (UAE), vibrocavitation-assisted (VAE). Principal component analysis (PCA) revealed clear separation extracts obtained NADES1 (choline chloride/malic acid) NADES2 (sorbitol/malic acid/water). Based results hierarchical clustering normalized further statistical evaluation t-test, it could be concluded that showed superior efficiency all addressed. this NADES was more detail. PCA followed t-test yielded only 3 efficiently whereas 46 compounds abundant VAE. When VAE UAE compared, 108 appeared VAE, 1 recovered UAE. These facts clearly indicate advantage method over maceration Seven twenty-seven tentatively identified tandem (MS/MS) found first time. Additional studies necessary understand applicability other plant materials.
Язык: Английский
Процитировано
12
Phytochemistry Letters, Год журнала: 2021, Номер 46, С. 71 - 78
Опубликована: Окт. 6, 2021
Язык: Английский
Процитировано
42
Molecules, Год журнала: 2022, Номер 27(13), С. 4271 - 4271
Опубликована: Июль 2, 2022
Peucedanum ostruthium (L.) W. D. J. Koch (Apiaceae) is a worldwide perennial herb native to the mountains of central Southern Europe. The rhizome has long tradition in popular medicine, while ethnobotanical surveys have revealed local uses leaves for superficial injuries. To experimentally validate these uses, plant material was collected Gran Paradiso National Park, Aosta Valley, Italy, and were micromorphologically phytochemically characterized. Polyphenol-enriched hydroalcoholic leaf extracts, used cell-free assays, showed strong concentration-dependent antioxidant anti-inflammatory activities. In vitro tests cyclooxygenase lipoxygenase inhibition by extract, extract induced only inhibition. MTT assays on HaCaT keratinocytes L929 fibroblasts low cytotoxicity extracts. scratch wound test resulted induction closure with effect lower. same cells similar both results confirmed traditional medicinal as an healing remedy injuries but also highlighted that can be exploited purposes equal or superior effectiveness.
Язык: Английский
Процитировано
29
Heliyon, Год журнала: 2023, Номер 9(10), С. e20232 - e20232
Опубликована: Сен. 15, 2023
Chrysanthemum is a flowering plant belonging to genus of the dicotyledonous herbaceous annual Asteraceae (Compositae) family. It perpetual plant, mostly cultivated for medicinal purposes; generally, used in popular drinks due its aroma and flavor. primarily China, Japan, Europe, United States. These flowers were extensively various healthcare systems treating diseases. are rich phenolic compounds exhibit strong properties including antioxidant, antimicrobial, anti-inflammatory, anticancer, anti-allergic, anti-obesity, immune regulation, hepatoprotective, nephroprotective activities. The main aim present review was investigate nutritional profile, phytochemistry, biological activities different species. Also, critical discussion diverse metabolites or bioactive constituents highlighted review. Moreover, flower extracts have been assessed possess phytochemical such as cyanidin-3-O-(6″-O-malonyl) glucoside, delphinidin 3-O-(6" -O-malonyl) glucoside-3′, rutin, quercetin, isorhamnetin, rutinoside, others. profiles potential health benefits, leading their utilization production supplementary food products pharmaceutical drugs within industry. However, more comprehensive research studies/investigations still needed further discover benefits human animal utilization.
Язык: Английский
Процитировано
20
Journal of the European Academy of Dermatology and Venereology, Год журнала: 2023, Номер 37(11), С. 2208 - 2221
Опубликована: Март 13, 2023
Vitiligo is a common chronic skin disease which has an adverse impact on patients' life. Its pathogenesis complex, involving autoimmunity and oxidative stress (OS). Autoimmunity leads to the loss of epidermal melanocytes formation depigmented patches disease. Treatment vitiligo should control exaggerated immune response arrest progress active disease, then promote repigmentation. Wnt/β-catenin signalling pathway been recent interest in vitiligo. downregulated Upregulation possibly autoimmune by protecting melanocyte from OS damage, inhibiting CD8+ T cell effector differentiation enhancing Treg. plays critical role regeneration driving stem cells (McSCs) into melanocytes. Promoting can not only but also Some main effective therapies for are likely work activating signalling. Agents that enhance effect may become potential candidates development new drugs treatment.
Язык: Английский
Процитировано
18
Cell Biochemistry and Function, Год журнала: 2024, Номер 42(1)
Опубликована: Янв. 1, 2024
Abstract Conventional treatment methods are not effective enough to fight the rapid increase in cancer cases. The interest is increasing investigation of herbal sources for development new anticancer therapeutics. This study aims investigate antitumor capacity Hypericum alpestre (H. alpestre) extract vitro and vivo, either alone or combination with inhibitors l ‐arginine/polyamine/nitric oxide (NO) pathway, characterize its active phytochemicals using advanced chromatographic techniques. Our previous reports suggest beneficial effects arginase inhibitor NG‐hydroxy‐nor‐ ‐arginine NO NG‐nitro‐Larginine methyl ester breast via downregulation polyamine synthesis. Here, properties H. combinations were explored a rat model mammary gland carcinogenesis induced by subcutaneous injection 7,12‐dimethylbenz[a]anthracene. revealed strong antiradical activity aerial part chemical (DPPH/ABTS) tests. In antioxidant test, demonstrated pro‐oxidant characteristics human colorectal (HT29) cells, which contingent upon hemostatic condition cells. expressed cytotoxic effect on HT29 (MCF‐7) cells measured MTT test. According comet assay results, did exhibit genotoxic nor possessed antigenotoxic Overall, 233 substances have been identified annotated LC‐Q‐Orbitrap HRMS system. vivo experiments models that activated enzymes liver, brain, tumors. combined chemotherapeutic agents attenuated cancer‐like histological alterations showed significant reductions tumor blood vessel area. Thus, N ω ‐OH‐nor‐ ‐nitro‐ ester, exhibits pro‐ antioxidant, antiangiogenic, effects.
Язык: Английский
Процитировано
8
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159705 - 159705
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1