Marine Drugs,
Год журнала:
2018,
Номер
16(8), С. 279 - 279
Опубликована: Авг. 14, 2018
The
increase
of
many
deadly
diseases
like
infections
by
multidrug-resistant
bacteria
implies
re-inventing
the
wheel
on
drug
discovery.
A
better
comprehension
metabolisms
and
regulation
diseases,
in
knowledge
based
study
disease-born
microorganisms’
genomes,
development
more
representative
disease
models
improvement
techniques,
technologies,
computation
applied
to
biology
are
advances
that
will
foster
discovery
upcoming
years.
In
this
paper,
several
aspects
current
methodologies
for
antibacterial
antifungals,
anti-tropical
antibiofilm
antiquorum
sensing,
anticancer
neuroprotectors
considered.
For
discovery,
two
different
complementary
approaches
can
be
applied:
classical
pharmacology,
also
known
as
phenotypic
which
is
historical
basis
reverse
designated
target-based
Screening
methods
have
been
used
discover
new
natural
products
mainly
from
terrestrial
origin.
Examples
marine
provided.
section
future
trends
provides
a
comprehensive
overview
recent
pharmaceutical
industry.
Journal of the American Chemical Society,
Год журнала:
2019,
Номер
141(37), С. 14878 - 14888
Опубликована: Сен. 4, 2019
The
synthesis
of
highly
acidic
metal–organic
frameworks
(MOFs)
has
attracted
significant
research
interest
in
recent
years.
We
report
here
the
design
a
strongly
Lewis
MOF,
ZrOTf-BTC,
through
two-step
transformation
MOF-808
(Zr-BTC)
secondary
building
units
(SBUs).
Zr-BTC
was
first
treated
with
1
M
hydrochloric
acid
solution
to
afford
ZrOH-BTC
by
replacing
each
bridging
formate
group
pair
hydroxide
and
water
groups.
resultant
further
trimethylsilyl
triflate
(Me3SiOTf)
ZrOTf-BTC
taking
advantage
oxophilicity
Me3Si
group.
Electron
paramagnetic
resonance
spectra
Zr-bound
superoxide
fluorescence
N-methylacridone
provided
quantitative
measurement
acidity
an
energy
splitting
(ΔE)
0.99
eV
between
πx*
πy*
orbitals,
which
is
competitive
homogeneous
benchmark
Sc(OTf)3.
shown
be
active
solid
catalyst
for
broad
range
important
organic
transformations
under
mild
conditions,
including
Diels–Alder
reaction,
epoxide
ring-opening
Friedel–Crafts
acylation,
alkene
hydroalkoxylation
reaction.
MOF
outperformed
Sc(OTf)3
terms
both
catalytic
activity
lifetime.
Moreover,
we
developed
ZrOTf-BTC@SiO2
composite
as
efficient
continuous
flow
catalysis.
Zr
centers
feature
identical
coordination
environment
based
on
spectroscopic
evidence.
displayed
exceptionally
high
turnover
numbers
(TONs)
1700
2700
326
acylation
conditions.
have
thus
created
sites
MOFs
via
triflation
constructed
MOF@SiO2
catalysis
transformations.
Frontiers in Marine Science,
Год журнала:
2021,
Номер
8
Опубликована: Март 16, 2021
Coastal
countries
have
traditionally
relied
on
the
existing
marine
resources
(e.g.,
fishing,
food,
transport,
recreation,
and
tourism)
as
well
tried
to
support
new
economic
endeavors
(ocean
energy,
desalination
for
water
supply,
seabed
mining).
Modern
societies
lifestyle
resulted
in
an
increased
demand
dietary
diversity,
better
health
well-being,
biomedicines,
natural
cosmeceuticals,
environmental
conservation,
sustainable
energy
sources.
These
societal
needs
stimulated
interest
of
researchers
diverse
underexplored
environments
promising
sources
biomolecules
biomass,
they
are
addressed
by
emerging
field
(blue)
biotechnology.
Blue
biotechnology
provides
opportunities
a
wide
range
initiatives
commercial
pharmaceutical,
biomedical,
cosmetic,
nutraceutical,
feed,
agricultural,
related
industries.
This
article
synthesizes
essence,
opportunities,
responsibilities,
challenges
encountered
outlines
attainment
valorization
directly
derived
or
bio-inspired
products
from
organisms.
First,
concept
bioeconomy
is
introduced.
Then,
diversity
bioresources
including
overview
most
prominent
organisms
their
potential
biotechnological
uses
described.
followed
introducing
methodologies
exploration
these
main
use
case
scenarios
food
agronomy,
bioremediation
climate
change,
materials,
healthcare,
well-being
sectors.
The
key
aspects
fields
legislation
funding
provided,
with
emphasis
importance
communication
stakeholder
engagement
at
all
levels
development.
Finally,
vital
overarching
concepts,
such
quadruple
helix
Responsible
Research
Innovation
principle
highlighted
important
follow
within
field.
authors
this
review
collaborating
under
European
Commission-funded
Cooperation
Science
Technology
(COST)
Action
Ocean4Biotech
–
transdisciplinary
networking
platform
focus
study
state
affairs.
Natural Product Reports,
Год журнала:
2021,
Номер
39(3), С. 560 - 595
Опубликована: Окт. 9, 2021
The
mangrove
forests
are
a
complex
ecosystem
occurring
at
tropical
and
subtropical
intertidal
estuarine
zones
nourish
variety
of
fungi
that
produce
1387
secondary
metabolites
with
the
feature
source,
chemical
bioactive
diversity.
Marine Drugs,
Год журнала:
2022,
Номер
20(1), С. 47 - 47
Опубликована: Янв. 3, 2022
Tetrodotoxin
(TTX)
is
a
crystalline,
weakly
basic,
colorless
organic
substance
and
one
of
the
most
potent
marine
toxins
known.
Although
TTX
was
first
isolated
from
pufferfish,
it
has
been
found
in
numerous
other
organisms
few
terrestrial
species.
Moreover,
tetrodotoxication
still
an
important
health
problem
today,
as
no
known
antidote.
poisonings
were
commonly
reported
Japan,
Thailand,
China,
but
today
risk
poisoning
spreading
around
world.
Recent
studies
have
shown
that
TTX-containing
fish
are
being
regions
Pacific
Indian
Ocean,
well
Mediterranean
Sea.
This
review
aims
to
summarize
pertinent
information
available
date
on
structure,
origin,
distribution,
mechanism
action
analytical
methods
used
for
detection
TTX,
organisms,
symptoms
poisoning,
incidence
worldwide.
Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products,
Год журнала:
2023,
Номер
unknown, С. 1 - 546
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(3), С. 1683 - 1683
Опубликована: Янв. 17, 2023
(1)
Background:
Polyunsaturated
fatty
acids
(PUFAs)
are
known
for
their
ability
to
protect
against
numerous
metabolic
disorders.
The
consumption
of
oily
fish
is
the
main
source
PUFAs
in
human
nutrition
and
commonly
used
supplement
production.
However,
seafood
an
overexploited
that
cannot
be
guaranteed
cover
global
demands.
Furthermore,
it
not
consumed
by
everyone
ecological,
economic,
ethical,
geographical
taste
reasons.
growing
demand
natural
dietary
sources
suggests
current
nutritional
insufficient
meet
needs,
less
will
be.
Therefore,
crucial
find
sustainable
acceptable
all,
meeting
world
population’s
needs.
(2)
Scope:
This
review
aims
evaluate
recent
evidence
about
alternative
plant
essential
acids,
focusing
on
long-chain
omega-3
(n-3)
PUFAs.
(3)
Method:
A
structured
search
was
performed
PubMed
engine
select
available
data
from
interventional
studies
using
non-animal
origin.
(4)
Results:
Several
promising
have
emerged
literature,
such
as
algae,
microorganisms,
plants
rich
stearidonic
acid
GM
plants.
costs,
acceptance
adequate
formulation
deserve
further
investigation.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
The
marine
environment
has
remained
a
source
of
novel
biological
molecules
with
diversified
applications.
ecological
and
diversity,
along
unique
physical
environment,
have
provided
the
evolutionary
advantage
to
plant,
animals
microbial
species
thriving
in
ecosystem.
In
light
fact
that
microorganisms
frequently
interact
symbiotically
or
mutualistically
higher
including
corals,
fish,
sponges,
algae,
this
paper
intends
examine
potential
as
niche
for
bacteria.
This
review
aims
analyze
summarize
modern
literature
data
on
biotechnological
fungi
bacteria
producers
wide
range
practically
valuable
products
(surfactants,
glyco-and
lipopeptides,
exopolysaccharides,
enzymes,
metabolites
different
activities:
antimicrobial,
antitumor,
cytotoxic).
Hence,
study
bioactive
secondary
from
is
need
hour.
scientific
novelty
lies
first
time,
new
resources
obtaining
biologically
active
natural
—
were
generalized.
investigates
various
kinds
derived
microorganisms,
specifically
focusing
products.
It
provides
summary
regarding
antibacterial,
antimalarial,
anticarcinogenic,
antibiofilm,
anti-inflammatory
effects
demonstrated
by
microorganisms.
There
currently
great
applied
research
standpoint
human
animal
health.
Antibiotics,
Год журнала:
2018,
Номер
7(2), С. 44 - 44
Опубликована: Май 22, 2018
Actinomycetes
have
been
proven
to
be
an
excellent
source
of
secondary
metabolites
for
more
than
half
a
century.
Exhibiting
various
bioactivities,
they
provide
valuable
approved
drugs
in
clinical
use.
Most
microorganisms
are
still
untapped
terms
their
capacity
produce
metabolites,
since
only
small
fraction
can
cultured
the
laboratory.
Thus,
improving
cultivation
techniques
extend
range
metabolite
producers
accessible
under
laboratory
conditions
is
important
first
step
prospecting
underexplored
sources
isolation
novel
antibiotics.
Currently
uncultured
actinobacteria
made
available
by
bioprospecting
extreme
or
simply
habitats
other
soil.
Furthermore,
bioinformatic
analysis
genomes
reveals
most
harbour
many
biosynthetic
gene
clusters
compounds
identified
from
any
single
strain,
which
translates
into
silent
potential
microbial
world
production
yet
unknown
natural
products.
This
review
covers
discovery
strategies
and
innovative
methods
recently
employed
access
reservoir
The
focus
order
actinomycetes
although
approaches
similarly
applicable
microbes.
Advanced
methods,
genomics-
metagenomics-based
approaches,
as
well
modern
metabolomics-inspired
highlighted
emphasise
interplay
different
disciplines
improve
