Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
57(33), С. 10718 - 10722
Опубликована: Июнь 13, 2018
Abstract
The
ability
of
mechanochemistry
to
alter
established
chemical
selectivity
is
demonstrated.
A
copper(I)‐catalyzed
mechanochemical
aldehyde/alkyne/amine
coupling
using
calcium
carbide
as
the
acetylene
source
provides
selective
access
1,4‐diamino‐2‐butynes,
which
contrasts
classical
approaches
that
provide
propargylamine‐type
products.
Solventless
milling
conditions
were
found
be
essential
unmask
3
products
with
new
compositions.
ChemSusChem,
Год журнала:
2021,
Номер
14(10), С. 2145 - 2162
Опубликована: Апрель 9, 2021
In
recent
years,
mechanochemistry
has
been
growing
into
a
widely
accepted
alternative
for
chemical
synthesis.
addition
to
their
efficiency
and
practicality,
mechanochemical
reactions
are
also
recognized
sustainability.
The
association
between
Green
Chemistry
often
originates
from
the
solvent-free
nature
of
most
protocols,
which
can
reduce
waste
production.
However,
satisfies
more
than
one
Principles
Chemistry.
this
Review
we
will
present
series
examples
that
clearly
illustrate
how
significantly
contribute
fulfillment
in
holistic
manner.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
58(11), С. 3285 - 3299
Опубликована: Ноя. 12, 2018
Abstract
In
recent
years,
the
application
of
mechanical
energy
to
chemical
systems
has
repeatedly
proven
beneficial
facilitate
transformations
in
various
areas
chemistry.
Today,
a
systematic
body
evidence
indicates
that
mechanochemistry
holds
great
promise
become
game‐changer
synthesis.
Not
only
does
permit
access
products
are
inaccessible
by
established
means
(e.g.
purely
thermal
activation),
mechanochemical
reactions
often
outperform
their
solution‐based
counterparts
terms
sustainability.
Most
carried
out
ball
milling
techniques
involve
solids
and
liquids,
but
number
with
gaseous
reactants
is
increasing.
The
aim
this
Minireview
provide
an
overview
involving
samples
highlight
advances
technology
for
safe
handling
reagents.
Examples
proceeding
at
interface
solid–/liquid–/gas–gas
led
significant
improvements
reactivity
or
selectivity
will
also
be
highlighted.
ACS Catalysis,
Год журнала:
2020,
Номер
10(15), С. 8344 - 8394
Опубликована: Май 27, 2020
The
extraordinary
impact
of
metal-based
complexes
on
synthetic
methods
is
still
recognized
nowadays,
and
attempts
are
currently
undertaken
to
further
extend
the
use
metal-assisted
chemistry
environmentally
friendly
processes
within
strongly
invoked
green
paradigm.
In
recent
years,
mechanochemistry
seems
provide
attractive
responses
with
processing
having
origins
lost
in
mists
time.
Focusing
panorama
organic
synthesis,
this
Review
highlights
some
recently
developed
mechanochemical
reactions
introduce
reader
into
fascinating,
quite
unexplored
world
mechanochemistry.
Mechanochemical
transformations
have
made
chemists
enter
unknown
territories,
forcing
a
different
chemistry
perspective.
While
questioning
or
revisiting
familiar
concepts
belonging
to
solution
chemistry,
mechanochemistry
has
broken
new
ground,
especially
in
the
panorama
of
organic
synthesis.
Not
only
does
it
foster
"thinking
outside
box",
but
also
opened
reaction
paths,
allowing
overcome
weaknesses
traditional
exactly
where
use
well-established
solution-based
methodologies
rules
out
progress.
In
this
Review,
reader
is
introduced
an
intriguing
research
subject
not
yet
fully
explored
and
waiting
for
improved
understanding.
Indeed,
study
mainly
focused
on
that,
although
impossible
solution,
become
possible
under
mechanochemical
processing
conditions,
simultaneously
entailing
innovation
expanding
chemical
space.
Chemical Reviews,
Год журнала:
2021,
Номер
121(20), С. 12548 - 12680
Опубликована: Авг. 13, 2021
As
the
"chemical
chameleon",
sulfonyl-containing
compounds
and
their
variants
have
been
merged
with
various
types
of
reactions
for
efficient
construction
diverse
molecular
architectures
by
taking
advantage
incredible
reactive
flexibility.
Currently,
involvement
in
radical
transformations,
which
sulfonyl
group
typically
acts
as
a
leaving
via
selective
C–S,
N–S,
O–S,
S–S,
Se–S
bond
cleavage/functionalization,
has
facilitated
new
formation
strategies
are
complementary
to
classical
two-electron
cross-couplings
organometallic
or
ionic
intermediates.
Considering
great
influence
synthetic
potential
these
novel
avenues,
we
summarize
recent
advances
this
rapidly
expanding
area
discussing
reaction
designs,
substrate
scopes,
mechanistic
studies,
limitations,
outlining
state-of-the-art
processes
involved
radical-mediated
desulfonylation
related
transformations.
With
specific
emphasis
on
applications,
believe
review
will
be
useful
medicinal
organic
chemists
who
interested
chemistry
particular.
Advanced Materials,
Год журнала:
2022,
Номер
34(46)
Опубликована: Янв. 11, 2022
Abstract
Mechanochemistry
with
solvent‐free
and
environmentally
friendly
characteristics
is
one
of
the
most
promising
alternatives
to
traditional
liquid‐phase‐based
reactions,
demonstrating
epoch‐making
significance
in
realization
different
types
chemistry.
utilizes
mechanical
energy
promote
physical
chemical
transformations
design
complex
molecules
nanostructured
materials,
encourage
dispersion
recombination
multiphase
components,
accelerate
reaction
rates
efficiencies
via
highly
reactive
surfaces.
In
particular,
mechanochemistry
deserves
special
attention
because
it
capable
endowing
materials
unique
properties.
Herein,
latest
advances
progress
for
preparation
modification
are
reviewed.
An
outline
basic
knowledge,
methods,
mechanochemical
strategies
presented,
distinguishing
this
review
from
reviews
that
only
focus
on
ball‐milling.
Next,
followed
by
a
detailed
insightful
discussion
mechanochemistry‐involved
conversion
storage
applications.
The
comprehensively
covers
aspects
mechanical/optical/chemical
electrical
energy.
Finally,
next‐generation
advanced
proposed.
This
intended
bring
frontline
guide
burgeoning
field
interdisciplinary
research
developing
greener
force.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2020,
Номер
8(24), С. 8881 - 8893
Опубликована: Июнь 10, 2020
Recently,
the
application
of
mechanochemical
strategies
in
organic
synthesis
has
attracted
attention
both
academic
and
industrial
chemical
communities.
The
high
efficiency
low
environmental
impact
processes
performed
by
mechanical
activation
positioned
methods
among
salient
green
techniques
since
it
allows
accomplishment
most
sustainable
chemistry
principles.
In
particular,
mechanochemistry
been
used
as
a
tool
for
active
pharmaceutical
ingredients
via
or
through
biocatalytic
protocols
using
enzymes
with
outstanding
results,
while
simultaneously
increasing
sustainability
process.
this
regard,
main
purpose
present
perspective
is
to
summarize
current
developments
mechanoenzymatic
approaches
pharmacologically
compounds.
importance
these
so-called
medicinal
field
will
be
highlighted.
