Printability and Shape Fidelity of Bioinks in 3D Bioprinting

Chemical Reviews, Год журнала: 2020, Номер 120(19), С. 11028 - 11055

Опубликована: Авг. 28, 2020

Three-dimensional bioprinting uses additive manufacturing techniques for the automated fabrication of hierarchically organized living constructs. The building blocks are often hydrogel-based bioinks, which need to be printed into structures with high shape fidelity intended computer-aided design. For optimal cell performance, relatively soft and printable inks preferred, although these undergo significant deformation during printing process, may impair fidelity. While concept good or poor printability seems rather intuitive, its quantitative definition lacks consensus depends on multiple rheological chemical parameters ink. This review discusses qualitative methodologies evaluate bioinks extrusion- lithography-based bioprinting. physicochemical influencing discussed, together their importance in establishing new models, predictive tools methods that deemed instrumental design next-generation reproducible comparison structural performance.

Язык: Английский

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Direct Ink Writing: A 3D Printing Technology for Diverse Materials

Advanced Materials, Год журнала: 2022, Номер 34(28)

Опубликована: Март 5, 2022

Additive manufacturing (AM) has gained significant attention due to its ability drive technological development as a sustainable, flexible, and customizable scheme. Among the various AM techniques, direct ink writing (DIW) emerged most versatile 3D printing technique for broadest range of materials. DIW allows practically any material, long precursor can be engineered demonstrate appropriate rheological behavior. This acts unique pathway introduce design freedom, multifunctionality, stability simultaneously into printed structures. Here, comprehensive review complex structures from materials, including polymers, ceramics, glass, cement, graphene, metals, their combinations through multimaterial is presented. The begins with an overview fundamentals rheology, followed by in-depth discussion methods tailor different classes Then, diverse applications ranging electronics food biomedical industries are discussed. Finally, current challenges limitations this highlighted, prospects guideline toward possible futuristic innovations.

Язык: Английский

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Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Advanced Functional Materials, Год журнала: 2021, Номер 31(21)

Опубликована: Март 8, 2021

Abstract Bone tissue engineering (BTE) is a rapidly growing field aiming to create biofunctional that can integrate and degrade in vivo treat diseased or damaged tissue. It has become evident scaffold fabrication techniques are very important dictating the final structural, mechanical properties, biological response of implanted biomaterials. A comprehensive review current accomplishments on techniques, their structure, function properties for BTE provided herein. Different types biomaterials ranging from inorganic natural synthetic polymers related composites processing presented. Emergent scaffolding such as electrospinning, freeze‐drying, bioprinting, decellularization also discussed. Strategies improve vascularization potential immunomodulation, which considered grand challenge scaffolding,

Язык: Английский

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Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting

Journal of Biological Engineering, Год журнала: 2020, Номер 14(1)

Опубликована: Март 13, 2020

Abstract Hydrogels are a three-dimensional and crosslinked network of hydrophilic polymers. They can absorb large amount water or biological fluids, which leads to their swelling while maintaining 3D structure without dissolving (Zhu Marchant, Expert Rev Med Devices 8:607–626, 2011). Among the numerous polymers have been utilized for preparation hydrogels, polysaccharides gained more attention in area pharmaceutics; Sodium alginate is non-toxic, biocompatible, biodegradable polysaccharide with several unique physicochemical properties has used as delivery vehicles drugs (Kumar Giri et al., Curr Drug Deliv 9:539–555, 2012). Owing high-water content resembling natural soft tissue, hydrogels were studied lot scaffold. The formation occur by interactions anionic alginates multivalent inorganic cations through typical ionotropic gelation method. However, those applications require control some such mechanical stiffness, swelling, degradation, cell attachment, binding release bioactive molecules using chemical physical modifications hydrogel. In current review, an overview will be presented well methods producing hydrogels. next section present review paper, application defined drug chemotherapeutic agents. recent advances alginate-based describe later wound dressing bioink bioprinting.

Язык: Английский

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Commercial hydrogels for biomedical applications

Heliyon, Год журнала: 2020, Номер 6(4), С. e03719 - e03719

Опубликована: Апрель 1, 2020

Hydrogels are polymeric networks having the ability to absorb a large volume of water. Flexibility, versatility, stimuli-responsive, soft structure advantages hydrogels. It is classified based on its source, preparation, ionic charge, response, crosslinking and physical properties. used in various fields like agriculture, food industry, biosensor, biomedical, etc. Even though hydrogels industries, more researches going field biomedical applications because resembles living tissue, biocompatibility, biodegradability. Here, we mainly focused commercially available for wound dressings, contact lenses, cosmetic applications, tissue engineering, drug delivery.

Язык: Английский

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Relationship between Structure and Rheology of Hydrogels for Various Applications

Gels, Год журнала: 2021, Номер 7(4), С. 255 - 255

Опубликована: Дек. 9, 2021

Hydrogels have gained a lot of attention with their widespread use in different industrial applications. The versatility the synthesis and nature precursor reactants allow for varying range hydrogels mechanical rheological properties. Understanding behavior relationship between chemical structure resulting properties is crucial, focus this review. Specifically, we include detailed discussion on correlation characteristics possible Different tests such as time, temperature frequency sweep, among others, are described results those reported. most prevalent applications also discussed.

Язык: Английский

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Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering

Bioactive Materials, Год журнала: 2021, Номер 12, С. 327 - 339

Опубликована: Окт. 26, 2021

Bone tissue engineering has emerged as a significant research area that provides promising novel tools for the preparation of biomimetic hydrogels applied in bone-related diseases (e.g., bone defects, cartilage damage, osteoarthritis, etc.). Herein, thermal sensitive polymers PNIPAAm, Soluplus, etc.) were introduced into main chains to fabricate with injectability and compatibility those defect need minimally invasive surgery. Mineral ions calcium, copper, zinc, magnesium), an indispensable role maintaining balance organism, linked polymer form functional accelerating regeneration. In chemically triggered hydrogel section, advanced crosslinked by different molecular agents genipin, dopamine, caffeic acid, tannic acid) possess many advantages, including extensive selectivity, rapid gel-forming capacity tunable mechanical property. Additionally, photo crosslinking response mild condition can be photoinitiators I2959, LAP, eosin Y, riboflavin, under specific wavelength light. Moreover, enzyme also utilized regeneration due its excellent biocompatibility. Particularly, some key factors determine therapy effect mentioned. Finally, brief summaries remaining issues on how properly design clinical-oriented provided this review.

Язык: Английский

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Chitosan-based materials: Preparation, modification and application

Journal of Cleaner Production, Год журнала: 2022, Номер 355, С. 131825 - 131825

Опубликована: Апрель 20, 2022

Язык: Английский

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Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Materials Today Bio, Год журнала: 2021, Номер 13, С. 100186 - 100186

Опубликована: Дек. 9, 2021

Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left door open for further improvement their applications to revitalize impaired tissues. Hence, restoring functions. The implementation therapeutic protocols merge biomimetic scaffolds, bioactive molecules, cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended engineering other biomedical purposes. They can simulate physicochemical, mechanical, biological characters innate Also, they provide aqueous conditions cell growth, support 3D conformation, mechanical stability cells, serve potent delivery matrices molecules. Many natural artificial polymers were broadly utilized design these intelligent platforms with novel advanced characteristics tailored functionalities fit such applications. In present review, we highlighted different types smart/stimuli-responsive emphasis on synthesis scheme. Besides, mechanisms responsiveness stimuli elaborated. Their potential was discussed. Furthermore, exploitation targeted drug delivery, smart biosensors, actuators, 4D printing, culture outlined. addition, threw light self-healing biomedicine. Eventually, presented future perceptions Conclusively, current progress enhances prospective function intelligent, sophisticated systems

Язык: Английский

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4D Printing of Hydrogels: A Review

Advanced Functional Materials, Год журнала: 2020, Номер 30(31)

Опубликована: Май 28, 2020

Abstract 3D printing permits the construction of objects by layer‐by‐layer deposition material, resulting in precise control dimensions and properties complex printed structures. Although fabricates inanimate objects, emerging technology 4D allows for animated structures that change their shape, function, or over time when exposed to specific external stimuli after fabrication. Among materials used printing, hydrogels have attracted growing interest due availability various smart hydrogels. The reversible shape‐morphing hydrogel is driven a stress mismatch arising from different swelling degrees parts structure upon application stimulus. This review provides state‐of‐the‐art perspective. First, main technologies employed are briefly depicted, and, each one, required physico‐chemical precursor material. Then, been described, including stimuli‐responsive hydrogels, non‐responsive sensitive solvent absorption/desorption, multimaterial totally hydrogel‐based. Finally, current future applications this presented, requisites avenues improvement terms material discussed.

Язык: Английский

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