A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting

Materials, Год журнала: 2021, Номер 14(4), С. 858 - 858

Опубликована: Фев. 10, 2021

Sustaining the vital functions of cells outside organism requires strictly defined parameters. In order to ensure their optimal growth and development, it is necessary provide a range nutrients regulators. Hydrogels are excellent materials for 3D in vitro cell cultures. Their ability retain large amounts liquid, as well biocompatibility, soft structures, mechanical properties similar these living tissues, appropriate microenvironments that mimic extracellular matrix functions. The wide natural synthetic polymeric materials, simplicity physico-chemical modification, allow be adjusted different requirements. Sodium alginate-based hydrogel frequently used material culture. lack cell-interactive makes this polysaccharide most often applied combination with other including gelatin. both increases biological activity improves properties, making printing technology. use hydrogels inks allows accurate manufacturing scaffolds complex shapes geometries. aim paper an overview cultures, which mainly alginate–gelatin hydrogels, potential applications.

Язык: Английский

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Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Gels, Год журнала: 2022, Номер 8(3), С. 179 - 179

Опубликована: Март 14, 2022

Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due the increasing global demand for organ replacement and regeneration. In 3D bioprinting, which a step ahead of biomaterial printing, ink employed impregnated with cells, without compromising printability. This allows immediate scaffold cellularization generation complex structures. The use cell-laden inks or bio-inks provides opportunity enhanced cell differentiation fabrication Recognizing importance such bio-inks, current study comprehensively explores state art utilization based on natural polymers (biopolymers), as cellulose, agarose, alginate, decellularized matrix, bioprinting. Discussions regarding progress techniques approaches bioprinting polymers, limitations prospects concerning future trends human-scale are also presented.

Язык: Английский

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Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications

Carbohydrate Polymer Technologies and Applications, Год журнала: 2021, Номер 2, С. 100067 - 100067

Опубликована: Апрель 14, 2021

In this paper, a spotlight is shown on polysaccharides based biomaterials which have surfaced as versatile platform for different biomedical applications including drug delivery and tissue regeneration. Herein, structure unique properties of are described along with various functionalization strategies. Additionally, brief overview physical chemical crosslinking approaches to design derived provided. Due their inherent biocompatible biodegradable properties, being extensively explored performing difficult task under complex biological environment. Hence, recent developments in using functional especially engineering here. The studies reviewed here motivate fabricate novel outstanding functionality. Finally, future possibilities achieve widespread commercial use discussed.

Язык: Английский

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3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer Drugs

Cancers, Год журнала: 2021, Номер 14(1), С. 190 - 190

Опубликована: Дек. 31, 2021

Today, innovative three-dimensional (3D) cell culture models have been proposed as viable and biomimetic alternatives for initial drug screening, allowing the improvement of efficiency development. These are gaining popularity, given their ability to reproduce key aspects tumor microenvironment, concerning 3D architecture well interactions cells with extracellular matrix surrounding non-tumor cells. The development accurate may become beneficial decrease use laboratory animals in scientific research, accordance European Union's regulation on 3R rule (Replacement, Reduction, Refinement). This review focuses impact cancer discussing advantages, limitations, compatibility high-throughput screenings automated systems. An insight is also adequacy available readouts interpretation data obtained from models. Importantly, we emphasize need incorporation additional complementary microenvironment elements design models, towards improved predictive value efficacy.

Язык: Английский

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Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(16), С. 9035 - 9035

Опубликована: Авг. 12, 2022

Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest alginate formulations biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, bioadhesive characteristics, reiterates future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are colloidal polysaccharide group, which water-soluble, non-toxic, non-irritant. These linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) β-(1→4)-linked d-mannuronic (M) residues. Owing monosaccharide sequencing enzymatically governed reactions, alginates well-known essential bio-polymer group multifarious implementations. Additionally, alginate’s bio-adhesive property makes it significant industry. Alginate has shown immense potential wound healing applications date because gel-forming ability maintains structural resemblance extracellular matrices tissues can be altered perform numerous crucial functions. initial section this review will deliver a perception extraction source remarkable properties. Furthermore, we have aspired discuss current literature on utilization biopolymeric through administration routes. Finally, latest investigations composite addressed.

Язык: Английский

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State-of-the-art of 3D printing technology of alginate-based hydrogels—An emerging technique for industrial applications

Advances in Colloid and Interface Science, Год журнала: 2021, Номер 293, С. 102436 - 102436

Опубликована: Май 8, 2021

Язык: Английский

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Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer

Journal of Pharmaceutical Sciences, Год журнала: 2022, Номер 111(5), С. 1250 - 1261

Опубликована: Янв. 2, 2022

Язык: Английский

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Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine

Marine Drugs, Год журнала: 2023, Номер 21(3), С. 189 - 189

Опубликована: Март 18, 2023

Today, with the salient advancements of modern and smart technologies related to tissue engineering regenerative medicine (TE-RM), use sustainable biodegradable materials biocompatibility cost-effective advantages have been investigated more than before. Alginate as a naturally occurring anionic polymer can be obtained from brown seaweed develop wide variety composites for TE, drug delivery, wound healing, cancer therapy. This renewable biomaterial displays several fascinating properties such high biocompatibility, low toxicity, cost-effectiveness, mild gelation by inserting divalent cations (e.g., Ca2+). In this context, challenges still exist in relation solubility viscosity high-molecular weight alginate, density intra- inter-molecular hydrogen bonding, polyelectrolyte nature aqueous solution, lack suitable organic solvents. Herein, TE-RM applications alginate-based are deliberated, focusing on current trends, important challenges, future prospects.

Язык: Английский

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A comprehensive review on alginate-based delivery systems for the delivery of chemotherapeutic agent: Doxorubicin

Carbohydrate Polymers, Год журнала: 2021, Номер 259, С. 117696 - 117696

Опубликована: Янв. 26, 2021

Язык: Английский

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A Review of the Effect of Plasticizers on the Physical and Mechanical Properties of Alginate-Based Films

Molecules, Год журнала: 2023, Номер 28(18), С. 6637 - 6637

Опубликована: Сен. 15, 2023

In recent years, there has been a growing attempt to manipulate various properties of biodegradable materials use them as alternatives their synthetic plastic counterparts. Alginate is polysaccharide extracted from seaweed or soil bacteria that considered one the most promising for numerous applications. However, alginate potential applications relatively limited due brittleness, poor mechanical properties, scaling-up difficulties, and high water vapor permeability (WVP). Choosing an appropriate plasticizer can alleviate situation by providing higher flexibility, workability, processability, in some cases, hydrophobicity. This review paper discusses main results developments regarding effects plasticizers on alginate-based films during last decades. The used plasticizing were classified into different categories, behavior under concentrations conditions was studied. Moreover, drawback WVP are discussed. Finally, role improved processing lack knowledge aspects plasticized clarified, accordingly, recommendations more classical studies future offered.

Язык: Английский

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