ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(1), P. 801 - 812
Published: Jan. 14, 2022
Radiotherapy
is
widely
applied
for
multiple
malignant
tumors
ablation
in
the
clinic.
However,
redundant
doses
of
X-rays
might
destroy
normal
tissue
periphery
tumor
sites.
Here,
we
developed
an
integrated
nanosystem
(Bac@BNP)
composed
engineered
bacteria
(Bac)
and
Bi2S3
nanoparticles
(BNPs)
sensitizing
radiotherapy.
Bac
could
target
colonize
sites
alternatively,
which
overexpressed
cytolysin
A
(ClyA)
protein
to
regulate
cell
cycle
from
a
radioresistant
phase
radiosensitive
phase.
Simultaneously,
peptide-modified
BNPs,
as
radiosensitizer
with
high-Z
element,
was
released
surface
owing
matrix
metalloproteinase-2
(MMP-2)
response
microenvironment.
Under
X-ray
irradiation,
BNPs
enhance
radiotherapy
sensitivity
by
triggering
intracellular
generation
reactive
oxygen
species
(ROS),
coupled
DNA
damage.
In
this
constructed
nanosystem,
combination
Bac@BNP
irradiation
led
significant
suppression
breast
carcinoma
murine
models
reduced
side
effects.
ACS Energy Letters,
Journal Year:
2021,
Volume and Issue:
6(2), P. 739 - 768
Published: Jan. 29, 2021
Radiation
detection,
using
materials
to
convert
high-energy
photons
low-energy
(X-ray
imaging)
or
electrical
charges
detector),
has
become
essential
for
a
wide
range
of
applications
including
medical
diagnostic
technologies,
computed
tomography,
quality
inspection
and
security,
etc.
Metal
halide
perovskite-based
high-resolution
scintillation-imaging
screens
direct
conversion
detectors
are
promising
candidates
such
applications,
because
they
have
high
absorption
cross
sections
X-rays
due
their
heavy
atom
(e.g.,
Pb2+,
Bi3+,
I–)
compositions;
moreover,
these
solution-processable
at
low
temperature,
possessing
tunable
bandgaps,
near-unity
photoluminescence
quantum
yields,
trap
density,
charge
carrier
mobility,
fast
photoresponse.
In
this
review,
we
explore
decipher
the
working
mechanism
scintillators
as
well
key
advantages
perovskites
both
detection
approaches.
We
further
discuss
recent
advancements
in
research
area,
pointing
out
remaining
challenges
our
perspective
future
directions
toward
X-ray
applications.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Feb. 17, 2023
Abstract
Having
a
hypoxic
microenvironment
is
common
and
salient
feature
of
most
solid
tumors.
Hypoxia
has
profound
effect
on
the
biological
behavior
malignant
phenotype
cancer
cells,
mediates
effects
chemotherapy,
radiotherapy,
immunotherapy
through
complex
mechanisms,
closely
associated
with
poor
prognosis
in
various
patients.
Accumulating
studies
have
demonstrated
that
normalization
tumor
vasculature,
nanoparticle
carriers
biocarriers
can
effectively
increase
oxygen
concentration
microenvironment,
improve
drug
delivery
efficacy
radiotherapy.
They
also
infiltration
innate
adaptive
anti-tumor
immune
cells
to
enhance
immunotherapy.
Furthermore,
drugs
targeting
key
genes
hypoxia,
including
hypoxia
tracers,
hypoxia-activated
prodrugs,
hypoxia-inducible
factors
downstream
targets,
be
used
for
visualization
quantitative
analysis
antitumor
activity.
However,
relationship
between
an
area
research
requires
further
exploration.
Here,
we
investigated
potential
development
cancer,
changes
signaling
pathways
occur
adapt
environments,
mechanisms
hypoxia-induced
tolerance,
chemotherapeutic
enhanced
radiation
as
well
insights
applications
therapy.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(4), P. 1109 - 1143
Published: Jan. 1, 2020
As
star
material,
perovskites
have
been
widely
used
in
the
fields
of
optics,
photovoltaics,
electronics,
magnetics,
catalysis,
sensing,
etc.
However,
some
inherent
shortcomings,
such
as
low
efficiency
(power
conversion
efficiency,
external
quantum
etc.)
and
poor
stability
(against
water,
oxygen,
ultraviolet
light,
etc.),
limit
their
practical
applications.
Downsizing
materials
into
nanostructures
incorporating
rare
earth
(RE)
ions
are
effective
means
to
improve
properties
broaden
This
review
will
systematically
summarize
key
points
design,
synthesis,
property
improvements
application
expansion
RE-containing
(including
both
RE-based
RE-doped)
halide
oxide
perovskite
nanomaterials
(PNMs).
The
critical
factors
RE
elements
different
structures
rational
design
functional
be
discussed
detail.
advantages
disadvantages
synthesis
methods
for
PNMs
reviewed.
paper
also
experiences
selecting
suitable
designing
multi-functional
according
mechanisms
principles
REs
promoting
perovskites.
At
end
this
review,
we
provide
an
outlook
on
opportunities
challenges
various
fields.
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(3), P. 2585 - 2627
Published: Feb. 7, 2020
Nanotheranostics
is
one
of
the
biggest
scientific
breakthroughs
in
nanomedicine.
Most
currently
available
diagnosis
and
therapies
are
invasive,
time-consuming,
associated
with
severe
toxic
side
effects.
Nanotheranostics,
on
other
hand,
has
potential
to
bridge
this
gap
by
harnessing
capabilities
nanotechnology
nanomaterials
for
combined
therapeutics
diagnostics
markedly
enhanced
efficacy.
However,
nanomaterial
applications
nanotheranostics
still
its
infancy.
This
due
fact
that
each
disease
a
particular
microenvironment
well-defined
characteristics,
which
promotes
deeper
selection
criteria
meet
needs.
In
review,
we
have
outlined
how
designed
tailored
cancer
diseases
such
as
neurodegenerative,
autoimmune
(particularly
rheumatoid
arthritis),
cardiovascular
diseases.
The
penetrability
retention
biological
system,
therapeutic
strategy
used,
imaging
mode
selected
some
aspects
discussed
disease.
specific
properties
terms
feasibility,
physicochemical
challenges,
progress
clinical
trials,
toxicity,
their
future
application
translational
medicine
addressed.
Our
review
meticulously
critically
examines
various
nanomaterials,
including
graphene,
across
several
diseases,
offering
broader
perspective
emerging
field.
Cancers,
Journal Year:
2021,
Volume and Issue:
13(17), P. 4447 - 4447
Published: Sept. 3, 2021
Photodynamic
therapy
(PDT)
is
a
promising
against
cancer.
Even
though
it
has
been
investigated
for
more
than
100
years,
scientific
publications
have
grown
exponentially
in
the
last
two
decades.
For
this
reason,
we
present
brief
compendium
of
reviews
decades
classified
under
different
topics,
namely,
overviews,
about
specific
cancers,
and
meta-analyses
photosensitisers,
PDT
mechanisms,
dosimetry,
light
sources.
The
key
issues
main
conclusions
are
summarized,
including
ways
means
to
improve
outcomes.
Due
broad
scope
work
being
first
time
that
latest
performed
PDT,
may
be
interest
wide
audience.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(4), P. 6147 - 6191
Published: March 19, 2021
Janus
nanoparticles
(JNPs)
refer
to
the
integration
of
two
or
more
chemically
discrepant
composites
into
one
structure
system.
Studies
JNPs
have
been
significant
interest
due
their
interesting
characteristics
stemming
from
asymmetric
structures,
which
can
integrate
different
functional
properties
and
perform
synergetic
functions
simultaneously.
Herein,
we
present
recent
progress
particles,
comprehensively
detailing
fabrication
strategies
applications.
First,
classification
is
divided
three
blocks,
consisting
polymeric
composites,
inorganic
hybrid
polymeric/inorganic
composites.
Then,
are
alternately
summarized,
examining
self-assembly
strategy,
phase
separation
seed-mediated
polymerization,
microfluidic
preparation
nucleation
growth
methods,
masking
methods.
Finally,
various
intriguing
applications
presented,
including
solid
surfactants
agents,
micro/nanomotors,
biomedical
such
as
biosensing,
controlled
drug
delivery,
bioimaging,
cancer
therapy,
combined
theranostics.
Furthermore,
challenges
future
works
in
this
field
provided.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(50)
Published: Nov. 9, 2020
Chemotherapy
causes
off-target
toxicity
and
is
often
ineffective
against
solid
tumors.
Targeted
on-demand
release
of
chemotherapeutics
remains
a
challenge.
Here,
cancer-cell-membrane-coated
mesoporous
organosilica
nanoparticles
(MONs)
containing
X-ray-
reactive
oxygen
species
(ROS)-responsive
diselenide
bonds
for
controlled
doxorubicin
(DOX)
at
tumor
sites
are
developed.
DOX-loaded
MONs
coated
with
4T1
breast
cancer
cell
membranes
(CM@MON@DOX)
show
greater
accumulation
prolonged
blood
circulation
time
versus
an
uncoated
control
in
mice
bearing
orthotopic
mammary
Under
low-dose
X-ray
radiation,
the
exhibit
carrier
degradation-controlled
via
cleavage
bonds,
resulting
DOX-mediated
immunogenic
death
site.
Combination
PD-L1
checkpoint
blockade
further
enhances
inhibition
growth
metastasis
low
systemic
toxicity.
Together,
findings
promise
these
biomimetic,
radiation-responsive
diselenide-bond-bridged
chemo-immunotherapy.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
9(5)
Published: Dec. 19, 2021
Cancer
immunotherapy
has
achieved
promising
clinical
progress
over
the
recent
years
for
its
potential
to
treat
metastatic
tumors
and
inhibit
their
recurrences
effectively.
However,
low
patient
response
rates
dose-limiting
toxicity
remain
as
major
dilemmas
immunotherapy.
Stimuli-responsive
nanoparticles
(srNPs)
combined
with
offer
possibility
amplify
anti-tumor
immune
responses,
where
weak
acidity,
high
concentration
of
glutathione,
overexpressions
enzymes,
reactive
oxygen
species,
external
stimuli
in
act
triggers
controlled
drug
release.
This
review
highlights
design
srNPs
based
on
tumor
microenvironment
and/or
combine
different
drugs,
especially
immunoregulatory
agents,
which
eventually
realize
synergistic
malignant
primary
or
acquire
a
long-term
memory
prevent
recurrence.
The
authors
hope
that
this
can
provide
theoretical
guidance
construction
transformation
smart
delivery
cancer
