Advances in the Study of Metabolomics and Metabolites in Some Species Interactions DOI Creative Commons
Rui Liu,

Zheng-Xue Bao,

Pei‐Ji Zhao

и другие.

Molecules, Год журнала: 2021, Номер 26(11), С. 3311 - 3311

Опубликована: Май 31, 2021

In the natural environment, interactions between species are a common phenomena. The mechanisms of interaction different mainly studied using genomic, transcriptomic, proteomic, and metabolomic techniques. Metabolomics is crucial part system biology based on precision instrument analysis. last decade, emerging field metabolomics has received extensive attention. not only provides qualitative quantitative method for studying species, but also helps clarify defense host pathogen, to explore new metabolites with various biological activities. This review focuses methods progress interspecies metabolomics. Additionally, prospects challenges discussed.

Язык: Английский

Mass spectrometry-based metabolomics in microbiome investigations DOI
Anelize Bauermeister, Helena Mannochio-Russo, Letícia V. Costa‐Lotufo

и другие.

Nature Reviews Microbiology, Год журнала: 2021, Номер 20(3), С. 143 - 160

Опубликована: Сен. 22, 2021

Язык: Английский

Процитировано

334

Microalgal-bacterial consortia: From interspecies interactions to biotechnological applications DOI
Bing Zhang, Li Wei,

Yuan Guo

и другие.

Renewable and Sustainable Energy Reviews, Год журнала: 2019, Номер 118, С. 109563 - 109563

Опубликована: Ноя. 17, 2019

Язык: Английский

Процитировано

316

Recent advances in the application of metabolomics for food safety control and food quality analyses DOI
Shubo Li, Yufeng Tian,

Pingyingzi Jiang

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2020, Номер 61(9), С. 1448 - 1469

Опубликована: Май 22, 2020

As one of the omics fields, metabolomics has unique advantages in facilitating understanding physiological and pathological activities biology, physiology, pathology, food science. In this review, based on developments analytical chemistry tools, cheminformatics, bioinformatics methods, we highlight current applications safety, authenticity quality, traceability. Additionally, combined use with other techniques for "foodomics" is comprehensively described. Finally, latest advances, practical challenges limitations, requirements related to application are critically discussed, providing new insight into analysis.

Язык: Английский

Процитировано

289

Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis DOI Creative Commons
Mohamed A. Salem, Leonardo Perez de Souza, Ahmed Serag

и другие.

Metabolites, Год журнала: 2020, Номер 10(1), С. 37 - 37

Опубликована: Янв. 15, 2020

Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed hundreds to thousands metabolites, whereby the bioactivity can be represented by synergism between several metabolites. However, isolating every single compound from extract is not always possible due complex chemistry and presence most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool analysis crude extracts, leading paradigm shift research. Analytical methods such mass spectrometry (MS) nuclear magnetic resonance (NMR) used comprehensively annotate constituents plant screening, discovery well quality control purposes those required phytomedicine. In this review, current advancements sample preparation, measurements, data presented alongside few case studies successful applications these processes product discovery.

Язык: Английский

Процитировано

243

Ultraviolet Photodissociation Mass Spectrometry for Analysis of Biological Molecules DOI
Jennifer S. Brodbelt,

Lindsay Morrison,

Inês C. Santos

и другие.

Chemical Reviews, Год журнала: 2019, Номер 120(7), С. 3328 - 3380

Опубликована: Дек. 18, 2019

The development of new ion-activation/dissociation methods continues to be one the most active areas mass spectrometry owing broad applications tandem in identification and structural characterization molecules. This Review will showcase impact ultraviolet photodissociation (UVPD) as a frontier strategy for generating informative fragmentation patterns ions, especially biological molecules whose complicated structures, subtle modifications, large sizes often impede molecular characterization. UVPD energizes ions via absorption high-energy photons, which allows access dissociation pathways relative more conventional ion-activation methods. Applications analysis peptides, proteins, lipids, other classes biologically relevant are emphasized this Review.

Язык: Английский

Процитировано

237

Immunometabolism in the Brain: How Metabolism Shapes Microglial Function DOI
Louis‐Philippe Bernier, Elisa M. York, Brian A. MacVicar

и другие.

Trends in Neurosciences, Год журнала: 2020, Номер 43(11), С. 854 - 869

Опубликована: Сен. 18, 2020

Язык: Английский

Процитировано

184

Valorization of by-products from olive oil industry and added-value applications for innovative functional foods DOI

Patricia Gullón,

Beatriz Gullón, Gonzalo Astray

и другие.

Food Research International, Год журнала: 2020, Номер 137, С. 109683 - 109683

Опубликована: Сен. 18, 2020

Язык: Английский

Процитировано

166

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism DOI Creative Commons
Federica Danzi,

Raffaella Pacchiana,

Andrea Mafficini

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 22, 2023

Abstract Tumour cells have exquisite flexibility in reprogramming their metabolism order to support tumour initiation, progression, metastasis and resistance therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosynthetic redox status sustain increased energetic demand cells. Over last decades, cancer field has seen an explosion new biochemical technologies giving more tools than ever before navigate this complexity. Within cell or tissue, metabolites constitute direct signature molecular phenotype thus profiling concrete clinical applications oncology. Metabolomics fluxomics, are key technological approaches that mainly revolutionized enabling researchers both qualitative mechanistic model cancer. Furthermore, upgrade from bulk single-cell analysis provided unprecedented opportunity investigate biology at cellular resolution allowing depth quantitative complex heterogenous diseases. More recently, advent functional genomic screening allowed identification pathways, processes, biomarkers novel therapeutic targets concert with other allow patient stratification treatment regimens. This review is intended be guide for metabolism, highlighting current emerging technologies, emphasizing advantages, disadvantages potential leading development innovative anti-cancer

Язык: Английский

Процитировано

119

Advances in high throughput LC/MS based metabolomics: A review DOI Creative Commons
Robert S. Plumb, Lee A. Gethings,

Paul Rainville

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 160, С. 116954 - 116954

Опубликована: Янв. 27, 2023

Properly implemented, metabolic and lipidomic profiling can provide a deeper understanding of mammalian, plant bacterial biology. These omics-tools have developed matured over the last 40-years are now being deployed to valuable information in epidemiological studies, drug toxicology pharmacology, disease biology progression patient stratification. LC/MS has become technology choice for both lipid profiling, due its speed, sensitivity structural elucidation capabilities. In preceding two decades there been many technological methodological advances that facilitated evolution into rugged, reliable, easily tool. include, but not limited to, improvements chromatography (phases, columns, delivery system), instruments mass spectrometry, optimization sample preparation, introduction ion mobility, data analysis tools, metabolite databases, harmonized protocols, more widespread use quality control methods reference standards/matrices. Here, recent developments high throughput liquid chromatography/high resolution spectrometry phenotyping described. which may improved feature detection, increased laboratory efficiency quality, as well "biomarker" identification, discussed relation their potential application large clinical or biobank collections.

Язык: Английский

Процитировано

49

Metabolomics and chemometrics: The next-generation analytical toolkit for the evaluation of food quality and authenticity DOI Creative Commons
Pascual García-Pérez, Pier Paolo Becchi, Leilei Zhang

и другие.

Trends in Food Science & Technology, Год журнала: 2024, Номер 147, С. 104481 - 104481

Опубликована: Апрель 7, 2024

The advances in NMR and mass spectrometry metabolomics allows a comprehensive profiling of foods, potentially covering geographical origin, authenticity, quality integrity issues. However, mining specific effects within the corresponding datasets is challenging due to presence set interacting factors that finally determine signatures. This review provides an overview different approaches used food then focusing on chemometric for data interpretation. In particular, interpretation hierarchically presented, starting from unsupervised (PCA, hierarchical clusters) supervised multivariate statistics like OPLS AMOPLS multiblock ANOVA discriminant approaches. Finally, machine learning Artificial Neural Networks are discussed as novel emerging tool support Tailored advisable, rather than unique solutions, with naively provide qualitative recognition patterns, modelling markers identification. Nonetheless, approach able interpretate complex

Язык: Английский

Процитировано

27