Molecules,
Год журнала:
2021,
Номер
26(11), С. 3311 - 3311
Опубликована: Май 31, 2021
In
the
natural
environment,
interactions
between
species
are
a
common
phenomena.
The
mechanisms
of
interaction
different
mainly
studied
using
genomic,
transcriptomic,
proteomic,
and
metabolomic
techniques.
Metabolomics
is
crucial
part
system
biology
based
on
precision
instrument
analysis.
last
decade,
emerging
field
metabolomics
has
received
extensive
attention.
not
only
provides
qualitative
quantitative
method
for
studying
species,
but
also
helps
clarify
defense
host
pathogen,
to
explore
new
metabolites
with
various
biological
activities.
This
review
focuses
methods
progress
interspecies
metabolomics.
Additionally,
prospects
challenges
discussed.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2020,
Номер
61(9), С. 1448 - 1469
Опубликована: Май 22, 2020
As
one
of
the
omics
fields,
metabolomics
has
unique
advantages
in
facilitating
understanding
physiological
and
pathological
activities
biology,
physiology,
pathology,
food
science.
In
this
review,
based
on
developments
analytical
chemistry
tools,
cheminformatics,
bioinformatics
methods,
we
highlight
current
applications
safety,
authenticity
quality,
traceability.
Additionally,
combined
use
with
other
techniques
for
"foodomics"
is
comprehensively
described.
Finally,
latest
advances,
practical
challenges
limitations,
requirements
related
to
application
are
critically
discussed,
providing
new
insight
into
analysis.
Metabolites,
Год журнала:
2020,
Номер
10(1), С. 37 - 37
Опубликована: Янв. 15, 2020
Plant-derived
natural
products
have
long
been
considered
a
valuable
source
of
lead
compounds
for
drug
development.
Natural
extracts
are
usually
composed
hundreds
to
thousands
metabolites,
whereby
the
bioactivity
can
be
represented
by
synergism
between
several
metabolites.
However,
isolating
every
single
compound
from
extract
is
not
always
possible
due
complex
chemistry
and
presence
most
secondary
metabolites
at
very
low
levels.
Metabolomics
has
emerged
in
recent
years
as
an
indispensable
tool
analysis
crude
extracts,
leading
paradigm
shift
research.
Analytical
methods
such
mass
spectrometry
(MS)
nuclear
magnetic
resonance
(NMR)
used
comprehensively
annotate
constituents
plant
screening,
discovery
well
quality
control
purposes
those
required
phytomedicine.
In
this
review,
current
advancements
sample
preparation,
measurements,
data
presented
alongside
few
case
studies
successful
applications
these
processes
product
discovery.
Chemical Reviews,
Год журнала:
2019,
Номер
120(7), С. 3328 - 3380
Опубликована: Дек. 18, 2019
The
development
of
new
ion-activation/dissociation
methods
continues
to
be
one
the
most
active
areas
mass
spectrometry
owing
broad
applications
tandem
in
identification
and
structural
characterization
molecules.
This
Review
will
showcase
impact
ultraviolet
photodissociation
(UVPD)
as
a
frontier
strategy
for
generating
informative
fragmentation
patterns
ions,
especially
biological
molecules
whose
complicated
structures,
subtle
modifications,
large
sizes
often
impede
molecular
characterization.
UVPD
energizes
ions
via
absorption
high-energy
photons,
which
allows
access
dissociation
pathways
relative
more
conventional
ion-activation
methods.
Applications
analysis
peptides,
proteins,
lipids,
other
classes
biologically
relevant
are
emphasized
this
Review.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 22, 2023
Abstract
Tumour
cells
have
exquisite
flexibility
in
reprogramming
their
metabolism
order
to
support
tumour
initiation,
progression,
metastasis
and
resistance
therapies.
These
reprogrammed
activities
include
a
complete
rewiring
of
the
bioenergetic,
biosynthetic
redox
status
sustain
increased
energetic
demand
cells.
Over
last
decades,
cancer
field
has
seen
an
explosion
new
biochemical
technologies
giving
more
tools
than
ever
before
navigate
this
complexity.
Within
cell
or
tissue,
metabolites
constitute
direct
signature
molecular
phenotype
thus
profiling
concrete
clinical
applications
oncology.
Metabolomics
fluxomics,
are
key
technological
approaches
that
mainly
revolutionized
enabling
researchers
both
qualitative
mechanistic
model
cancer.
Furthermore,
upgrade
from
bulk
single-cell
analysis
provided
unprecedented
opportunity
investigate
biology
at
cellular
resolution
allowing
depth
quantitative
complex
heterogenous
diseases.
More
recently,
advent
functional
genomic
screening
allowed
identification
pathways,
processes,
biomarkers
novel
therapeutic
targets
concert
with
other
allow
patient
stratification
treatment
regimens.
This
review
is
intended
be
guide
for
metabolism,
highlighting
current
emerging
technologies,
emphasizing
advantages,
disadvantages
potential
leading
development
innovative
anti-cancer
TrAC Trends in Analytical Chemistry,
Год журнала:
2023,
Номер
160, С. 116954 - 116954
Опубликована: Янв. 27, 2023
Properly
implemented,
metabolic
and
lipidomic
profiling
can
provide
a
deeper
understanding
of
mammalian,
plant
bacterial
biology.
These
omics-tools
have
developed
matured
over
the
last
40-years
are
now
being
deployed
to
valuable
information
in
epidemiological
studies,
drug
toxicology
pharmacology,
disease
biology
progression
patient
stratification.
LC/MS
has
become
technology
choice
for
both
lipid
profiling,
due
its
speed,
sensitivity
structural
elucidation
capabilities.
In
preceding
two
decades
there
been
many
technological
methodological
advances
that
facilitated
evolution
into
rugged,
reliable,
easily
tool.
include,
but
not
limited
to,
improvements
chromatography
(phases,
columns,
delivery
system),
instruments
mass
spectrometry,
optimization
sample
preparation,
introduction
ion
mobility,
data
analysis
tools,
metabolite
databases,
harmonized
protocols,
more
widespread
use
quality
control
methods
reference
standards/matrices.
Here,
recent
developments
high
throughput
liquid
chromatography/high
resolution
spectrometry
phenotyping
described.
which
may
improved
feature
detection,
increased
laboratory
efficiency
quality,
as
well
"biomarker"
identification,
discussed
relation
their
potential
application
large
clinical
or
biobank
collections.
Trends in Food Science & Technology,
Год журнала:
2024,
Номер
147, С. 104481 - 104481
Опубликована: Апрель 7, 2024
The
advances
in
NMR
and
mass
spectrometry
metabolomics
allows
a
comprehensive
profiling
of
foods,
potentially
covering
geographical
origin,
authenticity,
quality
integrity
issues.
However,
mining
specific
effects
within
the
corresponding
datasets
is
challenging
due
to
presence
set
interacting
factors
that
finally
determine
signatures.
This
review
provides
an
overview
different
approaches
used
food
then
focusing
on
chemometric
for
data
interpretation.
In
particular,
interpretation
hierarchically
presented,
starting
from
unsupervised
(PCA,
hierarchical
clusters)
supervised
multivariate
statistics
like
OPLS
AMOPLS
multiblock
ANOVA
discriminant
approaches.
Finally,
machine
learning
Artificial
Neural
Networks
are
discussed
as
novel
emerging
tool
support
Tailored
advisable,
rather
than
unique
solutions,
with
naively
provide
qualitative
recognition
patterns,
modelling
markers
identification.
Nonetheless,
approach
able
interpretate
complex
