Journal of Heterocyclic Chemistry,
Год журнала:
2022,
Номер
60(4), С. 566 - 575
Опубликована: Ноя. 25, 2022
Abstract
A
series
of
substituted
N
‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amines
(5a–j)
(5ab
,
5ac)
were
synthesized
in
good
yield
and
characterized
for
their
structural
confirmation.
The
pure
quinoxaline
products
screened
in‐vitro
antibacterial
activity
against
Salmonella
paratyphi,
a
well‐known
food
borne
pathogen.
preliminary
results
revealed
that
among
the
series,
compounds
5a
5c
5d
5e
5f
5h
5ab
5ac
bearing
bromo,
fluoro,
methoxy,
methyl
groups
at
para
position
on
phenyl
ring
which
inturn
third
methyl,
benzoyl
sixth
emerged
as
potential
candidates
by
displaying
antisalmonella
activity.
Among
candidates,
effective
whereas
effectively
inhibited
biofilm
formation
.
Green Chemistry,
Год журнала:
2022,
Номер
24(6), С. 2602 - 2612
Опубликована: Янв. 1, 2022
Porous
polypyridine-oxadiazole
supported
iridium
catalysts
(PPO-Ir)
revealed
high
catalytic
activity
for
the
reaction
of
dimethyl-6-aminouracil
(including
1,3-dimethylbarbituric
acid,
2-aminobenzylamine)
with
alcohols.
The Journal of Organic Chemistry,
Год журнала:
2020,
Номер
86(1), С. 1023 - 1036
Опубликована: Дек. 16, 2020
A
straightforward
and
selective
reduction
of
nitroarenes
with
various
alcohols
was
efficiently
developed
using
an
iron
catalyst
via
a
hydrogen
transfer
methodology.
This
protocol
led
specifically
to
imines
in
30–91%
yields,
good
functional
group
tolerance.
Noticeably,
starting
from
o-nitroaniline
derivatives,
the
presence
alcohols,
benzimidazoles
can
be
obtained
64–72%
yields
when
reaction
performed
additional
oxidant,
DDQ,
quinoxalines
were
prepared
1,2-diols
28–96%
yields.
methodology,
unprecedented
at
for
imines,
also
provides
sustainable
alternative
preparation
benzimidazoles.
New Journal of Chemistry,
Год журнала:
2021,
Номер
45(30), С. 13214 - 13246
Опубликована: Янв. 1, 2021
Quinoxalines
are
a
class
of
N-heterocycles
which
present
in
variety
natural
and
synthetic
compounds.
They
act
as
versatile
building
block
synthesizing
novel
heterocyclic
scaffolds
important
intermediates
many
bioactive
have
achieved
immense
significance
organic
well
medicinal
chemistry.
Several
approaches
been
developed
to
afford
quinoxaline
derivatives.
In
this
review,
we
summarized
the
recent
progress
transition
metal-catalyzed
synthesis
quinoxalines.
Organic Letters,
Год журнала:
2024,
Номер
26(9), С. 1770 - 1774
Опубликована: Фев. 14, 2024
General
and
efficient
strategies
for
highly
diastereoselective
synthesis
of
divergent
heterocyclic
scaffolds
through
desymmetric
[3+3]
cycloaddition
p-quinamines
with
1,3-dipole
surrogates
hydroximoyl
halides
α-halohydroxamates
have
been
developed.
This
synthetic
protocol
provided
a
variety
architectures
containing
1,2,4-oxadiazine
hydroquinoxaline
skeletons
in
good
yields
wide
substrate
scope.
Organic Letters,
Год журнала:
2020,
Номер
22(21), С. 8291 - 8295
Опубликована: Сен. 11, 2020
We
herein
describe
a
practical
direct
amination
of
phenols
through
palladium-catalyzed
hydrogen-transfer-mediated
activation
method
to
synthesize
the
secondary
and
tertiary
amines.
In
this
conversion,
environmentally
friendly
water
inexpensive
ammonium
formate
were
used
as
solvent
reductant,
respectively.
A
range
amines,
including
aliphatic
aniline,
diamines,
could
be
coupled
effectively
by
achieve
mono/dual
cyclization
phenols.
This
study
not
only
provides
green
mild
strategy
for
synthesis
naphthylamines
but
also
expands
chloroquine
in
organic
chemistry.
Chinese Journal of Organic Chemistry,
Год журнала:
2022,
Номер
42(1), С. 190 - 190
Опубликована: Янв. 1, 2022
A
novel
method
for
the
synthesis
of
pyrazine
and
ketone
derivatives
was
developed
by
using
asymmetric
ligand-based
catalyst
[email protected]
screening
reaction
bases,
solvents,
temperatures
time
conducted
to
determine
optimal
conditions.The
scope
generality
this
methodology
pyrazines
were
tested
results
showed
that
catalytic
system
had
good
functional
tolerance.More
than
twenty
substrates
experiments
successfully
set
up,
with
moderate
high
yields
isolated.Additionally,
could
also
be
used
systhesis
ketones
in
yields.Furthermore,
mechanism
investigations
better
understand
pyrazines.The
recycling
test
TNP-Cu@rGO
investigated
still
maintain
activity
five
times.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(24), С. 16449 - 16457
Опубликована: Дек. 1, 2022
The
replacement
of
fossil
resources
with
biomass
in
the
construction
N-heterocycles
is
rapidly
attracting
research
interest.
Herein,
we
report
palladium-catalyzed
selective
hydrogenative
coupling
nitroarenes
and
phenols
based
on
a
transfer
hydrogenation
strategy,
allowing
straightforward
access
to
spirocyclic
pyrrolo-
indolo-fused
quinoxalines,
class
compounds
found
numerous
natural
alkaloids.
synthetic
protocol
characterized
by
broad
substrate
scope
utilization
biomass-derived
reactants
commercially
available
catalysts.
In
such
transformations,
high-pressure
explosive
hydrogen
are
not
required.
This
provides
new
for
converting
into
value-added
nitrogen-containing
chemicals.
