Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Год журнала: 2020, Номер 33(4)

Опубликована: Дек. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Язык: Английский

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Carbon dots as a new class of nanomedicines: Opportunities and challenges

Coordination Chemistry Reviews, Год журнала: 2021, Номер 442, С. 214010 - 214010

Опубликована: Май 12, 2021

Язык: Английский

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Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 176, С. 113891 - 113891

Опубликована: Июль 26, 2021

CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9) is a potent technology for gene-editing. Owing to its high specificity and efficiency, extensity used human diseases treatment, especially cancer, which involves multiple genetic alterations. Different concepts of cancer treatment by are established. However, significant challenges remain clinical applications. The greatest challenge therapy how safely efficiently deliver it target sites in vivo. Nanotechnology has greatly contributed drug delivery. Here, we present the action mechanisms CRISPR/Cas9, application focus on nanotechnology-based delivery gene editing immunotherapy pave way translation. We detail difficult barriers CRISIR/Cas9 vivo discuss relative solutions encapsulation, delivery, controlled release, cellular internalization, endosomal escape.

Язык: Английский

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Influencing factors and strategies of enhancing nanoparticles into tumors in vivo

Acta Pharmaceutica Sinica B, Год журнала: 2021, Номер 11(8), С. 2265 - 2285

Опубликована: Март 24, 2021

The administration of nanoparticles (NPs) first faces the challenges evading renal filtration and clearance reticuloendothelial system (RES). After that, NPs infiltrate through expanded endothelial space penetrated dense stroma tumor microenvironment to cells. As long as possible prolong time remaining in tissue, release active agent induce pharmacological action. This review provides a comprehensive summary physical chemical properties influence various biological factors microenvironment, discusses how improve final efficacy adjusting characteristics structure NPs. Perspectives future directions are also provided.

Язык: Английский

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Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance

npj Precision Oncology, Год журнала: 2024, Номер 8(1)

Опубликована: Фев. 10, 2024

Abstract Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and immunosuppressive nature microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components TME. M2-like TAMs are in facilitating metastasis as well augmenting tumors. This review encapsulates mechanisms that use to promote resistance. We also describe emerging therapeutic strategies currently targeting combination with other antitumor drugs, some still undergoing clinical trial evaluation. Furthermore, we summarize analyze various existing approaches for developing novel drugs target overcome resistance, highlighting how can effectively stop growth, metastasis,

Язык: Английский

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Amino‐Acid‐Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy

Advanced Materials, Год журнала: 2022, Номер 34(16)

Опубликована: Фев. 18, 2022

Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design photothermal remains extremely challenging due to vulnerability variability noncovalent interactions governing supramolecular self-assembly. Herein, it reported that amino acid encoding a facile potent means construct nanodrugs controlled therapeutic activities. It found amount type dominates assembled nanostructures, structural stability, energy-conversion pathway, mechanism resulting nanodrugs. Two optimized are endowed robust integrity against disassembly along high conversion efficiency, efficient cellular internalization, enhanced tumor accumulation, which result in more ablation. This work demonstrates offers an unprecedented opportunity construction remarkable photoactive nanomedicines toward diagnostics therapeutics.

Язык: Английский

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What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives

Coordination Chemistry Reviews, Год журнала: 2021, Номер 449, С. 214210 - 214210

Опубликована: Сен. 14, 2021

Язык: Английский

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Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles

Journal of Controlled Release, Год журнала: 2021, Номер 341, С. 227 - 246

Опубликована: Ноя. 22, 2021

Язык: Английский

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Metal-free bioorthogonal click chemistry in cancer theranostics

Chemical Society Reviews, Год журнала: 2022, Номер 51(4), С. 1336 - 1376

Опубликована: Янв. 1, 2022

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems. reactions between pair of biologically reactive groups can rapidly and specifically take place mild physiological milieu without perturbing inherent biochemical processes. Attributed their high selectivity efficiency, bioorthogonal significantly decrease background signals bioimaging. Compared with metal-catalyzed click reactions, metal-free are more biocompatible the metal catalyst-induced cytotoxicity. Although great number chemistry-based strategies have been reported for cancer theranostics, comprehensive review scarce highlight advantages these strategies. In this review, recent progress theranostics guided by will be depicted detail. The elaborate design as well tumor summarized future prospects emerging field emphasized.

Язык: Английский

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Towards principled design of cancer nanomedicine to accelerate clinical translation

Materials Today Bio, Год журнала: 2022, Номер 13, С. 100208 - 100208

Опубликована: Янв. 1, 2022

Nanotechnology in medical applications, especially oncology as drug delivery systems, has recently shown promising results. However, although these advances have been the pre-clinical stages, clinical translation of this technology is challenging. To create systems with increased treatment efficacy for translation, physicochemical characteristics nanoparticles such size, shape, elasticity (flexibility/rigidity), surface chemistry, and charge can be specified to optimize efficiency a given application. Consequently, interdisciplinary researchers focused on producing biocompatible materials, production technologies, or new formulations efficient loading, high stability. The effects design parameters studied

Язык: Английский

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