Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 1111 - 1137

Опубликована: Ноя. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Язык: Английский

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Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Год журнала: 2020, Номер 35, С. 100946 - 100946

Опубликована: Авг. 13, 2020

Язык: Английский

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advanced Materials, Год журнала: 2020, Номер 32(47)

Опубликована: Окт. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Язык: Английский

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Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Год журнала: 2022, Номер 9(22)

Опубликована: Июнь 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Язык: Английский

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Advanced biotechnology-assisted precise sonodynamic therapy

Chemical Society Reviews, Год журнала: 2021, Номер 50(20), С. 11227 - 11248

Опубликована: Янв. 1, 2021

Herein, we provide the enhancement of SDT effect through elaborate strategies including design and modification sonosensitizers, combination other therapy modalities, molecular imaging-guided for precise treatment.

Язык: Английский

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Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Antibiotics, Год журнала: 2022, Номер 11(2), С. 200 - 200

Опубликована: Фев. 4, 2022

Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As result, infectious diseases have become more challenging or even impossible treat, leading an increase morbidity mortality. Despite the failure of conventional, traditional therapy, past two decades, no novel class antibiotics has been introduced. Consequently, several alternative strategies combat these (multi-) drug-resistant microorganisms identified. The purpose this review is gather consider that are being applied proposed as potential alternatives antibiotics. These include combination techniques target enzymes proteins responsible for resistant bacteria, drug delivery systems, physicochemical methods, unconventional techniques, including CRISPR-Cas system. may change treatment multi-drug-resistant pathogens human clinical settings.

Язык: Английский

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Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 4996 - 5041

Опубликована: Янв. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Язык: Английский

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Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy

ACS Nano, Год журнала: 2020, Номер 14(11), С. 15119 - 15130

Опубликована: Ноя. 13, 2020

Sonodynamic therapy (SDT), which can generate reactive oxygen species (ROS) based on sonosensitizers under ultrasound (US) to kill tumor cells, has emerged as a noninvasive therapeutic modality with high tissue-penetration depth. Herein, ultrasmall iron-doped titanium oxide nanodots (Fe-TiO2 NDs) are synthesized via thermal decomposition strategy type of enhance SDT. Interestingly, the Fe doping in this system appears be crucial not only enhancing US-triggered ROS generation those NDs but also offering Fenton-catalytic function from endogenous H2O2 for chemodynamic (CDT). After polyethylene glycol (PEG) modification, Fe-TiO2-PEG demonstrate good physiological stability and biocompatibility. With efficient retention after intravenous injection revealed by vivo magnetic resonance (MR) fluorescent imaging, our Fe-TiO2 much better performance than commercial TiO2 nanoparticles owing combination CDT Moreover, most effectively excreted within one month, rendering no obvious long-term toxicity treated mice. Our work thus presents multifunctional sonosensitizer highly cancer treatment simply nanostructures metal ions.

Язык: Английский

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2D Piezoelectric Bi₂MoO₆ Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

Advanced Materials, Год журнала: 2021, Номер 33(51)

Опубликована: Окт. 16, 2021

Abstract Reducing the scavenging capacity of reactive oxygen species (ROS) and elevating ROS production are two primary goals developing novel sonosensitizers for sonodynamic therapy (SDT). Hence, ultrathin 2D Bi 2 MoO 6 –poly(ethylene glycol) nanoribbons (BMO NRs) designed as piezoelectric glutathione (GSH)‐enhanced SDT. In cancer cells, BMO NRs can consume endogenous GSH to disrupt redox homeostasis, GSH‐activated (GBMO) exhibit an oxygen‐deficient structure, which promote separation electron–hole pairs, thereby enhancing efficiency in The GBMO piezoelectric, ultrasonic waves introduce mechanical strain nanoribbons, resulting polarization band tilting, thus accelerating toxic production. as‐synthesized enable excellent computed tomography imaging tumors significant tumor suppression vitro vivo. A sonosensitizer‐mediated two‐step enhancement SDT process, is activated by amplified exogenous ultrasound, proposed. This process not only provides new options improving but also broadens application materials

Язык: Английский

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Engineering Macrophage Exosome Disguised Biodegradable Nanoplatform for Enhanced Sonodynamic Therapy of Glioblastoma

Advanced Materials, Год журнала: 2022, Номер 34(15)

Опубликована: Фев. 8, 2022

Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation damage to normal tissues, thus emerges as a promising cancer therapeutic modality for glioblastoma (GBM). However, the blood-brain barrier (BBB) hypoxic microenvironment greatly limit SDT efficiency. In this work, biodegradable nanoplatform (termed CSI) is fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO2 ) tumor hypoxia relief, then loaded with sonosensitizer indocyanine green (ICG). Inspired ability of macrophages cross BBB, CSI further coated AS1411 aptamer-modified macrophage exosomes form CSI@Ex-A, which possesses efficient BBB good cancer-cell-targeting capability. After cell endocytosis, highly expressed glutathione (GSH) triggeres biodegradation released CAT catalyzes hydrogen peroxide (H2 O2 produce relieve hypoxia. The GSH depletion self-supplying effectively enhances efficiency both in vitro vivo. addition, resulting CSI@Ex-A biocompatibility long circulation time. These findings demonstrate that may serve competent GBM therapy, potential clinical translation.

Язык: Английский

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