Biosensors and Bioelectronics, Год журнала: 2021, Номер 197, С. 113738 - 113738
Опубликована: Окт. 29, 2021
Язык: Английский
Bioactive Materials, Год журнала: 2022, Номер 19, С. 237 - 250
Опубликована: Апрель 20, 2022
The limited clinical response and serious side effect have been challenging in cancer immunotherapy resulting from immunosuppressive tumor microenvironment (TME) inferior drug targeting. Herein, an active targeting TME nanoplatform capable of revising the is designed. Briefly, gold nanorods (GNRs) are covered with silica dioxide (SiO2) then coated manganese (MnO2) to obtain GNRs@SiO2@MnO2 (GSM). Myeloid-derived suppressor cells (MDSCs) membrane further camouflaged on surface GSM GNRs@SiO2@MnO2@MDSCs (GSMM). In this system, GSMM inherits capacity MDSCs. localized plasmon resonance GNRs developed near-infrared II window by MnO2 layer coating, realizing NIR-II photothermal imaging photoacoustic GSMM. Based release Mn2+ acidic TME, can be also used for magnetic imaging. cells, catalyzes H2O2 into ·OH (chemodynamic therapy) CDT leading activate cGAS-STING, but directly acts STING inducing secretion type I interferons, pro-inflammatory cytokines chemokines. Additionally, therapy CDT-mediated immunogenic cell death enhance anti-tumor immunity via exposure CRT, HMGB1 ATP. summary, our realizes multimodal dual immunotherapy.
Язык: Английский
Процитировано
81
Nano Today, Год журнала: 2022, Номер 43, С. 101439 - 101439
Опубликована: Март 3, 2022
Язык: Английский
Процитировано
75
Coordination Chemistry Reviews, Год журнала: 2023, Номер 490, С. 215211 - 215211
Опубликована: Май 12, 2023
Язык: Английский
Процитировано
59
Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.
Язык: Английский
Процитировано
57
Chemical Society Reviews, Год журнала: 2023, Номер 52(22), С. 7707 - 7736
Опубликована: Янв. 1, 2023
This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.
Язык: Английский
Процитировано
54
Nano Research, Год журнала: 2023, Номер 17(1), С. 39 - 64
Опубликована: Июль 6, 2023
Язык: Английский
Процитировано
51
Advances in Colloid and Interface Science, Год журнала: 2023, Номер 323, С. 103050 - 103050
Опубликована: Ноя. 10, 2023
Язык: Английский
Процитировано
51
Energy Material Advances, Год журнала: 2023, Номер 4
Опубликована: Янв. 1, 2023
Over the past few decades, metal–organic frameworks (MOFs) have been recognized as most attractive energy-involved materials due to their unique features, including ultrahigh specific surface area, superior porous structure, and excellent customizability. Nevertheless, pristine MOFs suffer from low electronic conductivity chemical instability, which severely hindered large-scale applications. Recently, MXene with abundant terminations high metallic suggested a valid substrate improve stability of MOFs. Importantly, MXene/MOF composites enhanced conductivity, rich chemistry, hierarchical structure facilitate rapid electron/ion transfer deliver better electrochemical properties than that original through synergistic effects. Moreover, can be designed into various derivatives desired architecture performance. Therefore, elaborate synthesis hybrids for devices are great interest. Herein, we provided state-of-the-art review on progress in terms strategies Furthermore, put forward current challenges feasible research directions future development.
Язык: Английский
Процитировано
49
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(2), С. 1644 - 1656
Опубликована: Янв. 4, 2024
Photodynamic therapy (PDT), an emergent noninvasive cancer treatment, is largely dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen supply. However, therapeutic efficacy PSs greatly compromised by poor solubility, aggregation tendency, depletion within solid tumors during PDT in hypoxic microenvironments. Despite potential PS-based metal–organic frameworks (MOFs), addressing hypoxia remains challenging. Boron dipyrromethene (BODIPY) chromophores, with excellent photostability, have exhibited great bioimaging. their practical application suffers from limited chemical stability under harsh MOF synthesis conditions. Herein, we report first example Zr-based MOF, namely, 69-L2, exclusively constructed BODIPY-derived ligands via single-crystal to post-synthetic exchange, where direct solvothermal method not applicable. To increase performance hypoxia, modify 69-L2 fluorinated phosphate-functionalized methoxy poly(ethylene glycol). The resulting 69-L2@F carrier, enabling tumor oxygenation simultaneously acting as PS for reactive species (ROS) generation LED irradiation. We demonstrate that has enhanced effect triple-negative breast MDA-MB-231 cells both normoxia hypoxia. Following positive results, evaluated vivo activity hydrogel, local mice model achieving exceptional antitumor only 2 days. envision BODIPY-based Zr-MOFs provide solution relief maximize PDT, offering new insights into design promising MOF-based tumors.
Язык: Английский
Процитировано
43
Chemical Society Reviews, Год журнала: 2024, Номер 53(5), С. 2643 - 2692
Опубликована: Янв. 1, 2024
This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.
Язык: Английский
Процитировано
43