Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 19, 2025
Comprehensive
Summary
The
development
of
photodynamic
therapy
(PDT),
from
its
initial
discovery
effects
to
current
use
in
various
medical
conditions,
is
a
testament
therapeutic
potential.
Recent
breakthroughs
nanotechnology
have
significantly
enhanced
the
effectiveness
PDT.
Typical
nanomaterials
(NMs),
including
metal‐organic
frameworks
(MOFs),
covalent
organic
(COFs),
and
nanozymes
been
introduced
enhance
efficacy
because
they
can
delivery
PSs,
effectively
overcome
insufficient
targeting
specificity,
limited
tissue
penetration
depth,
hypoxic
microenvironments,
thereby
amplifying
efficacy.
However,
clinical
application
these
NMs
PDT
faces
several
challenges,
concerns
regarding
biocompatibility,
long‐term
biosafety,
economic
feasibility.
To
further
advance
PDT,
researchers
should
focus
on
designing
improve
outcomes,
exploring
combination
therapies
with
conducting
translational
trials
validate
safety
novel
approaches.
This
review
summarizes
recent
progress
based
NMs,
especially
MOFs,
COFs
their
disease
treatment.
We
aim
provide
guidance
for
future
research
practice
advancing
NMs‐enhanced
paving
way
more
effective
strategies.
Key
Scientists
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(12), С. 6244 - 6294
Опубликована: Янв. 1, 2024
This
review
highlights
the
promising
prospects
of
defective
zirconium-based
MOFs
in
addressing
challenging
energy-
and
environment-related
problems,
positioning
them
as
versatile
tools
toward
a
cleaner
more
sustainable
future.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(11), С. 2691 - 2710
Опубликована: Янв. 1, 2024
Over
the
past
two
decades,
metal–organic
frameworks
(MOFs)
have
garnered
substantial
scientific
interest
across
diverse
fields,
spanning
gas
storage,
catalysis,
biotechnology,
and
more.
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
14(8), С. 2262 - 2275
Опубликована: Фев. 20, 2024
Abstract
Due
to
the
severity
and
high
prevalence
of
cancer,
as
well
its
complex
pathological
condition,
new
strategies
for
cancer
treatment
diagnostics
are
required.
As
such,
it
is
important
design
a
toolbox
that
integrates
multiple
functions
on
single
smart
platform.
Theranostic
hydrogels
offer
an
innovative
personalized
method
tackle
while
also
considering
patient
comfort,
thereby
facilitating
future
implementation
translation
clinic.
In
terms
theranostic
systems
used
in
therapy,
nanoparticles
widely
diagnostic
therapeutic
tools.
Nanoparticles
can
achieve
systemic
circulation,
evade
host
defenses,
deliver
drugs
signaling
agents
at
targeted
site,
diagnose
treat
disease
cellular
molecular
level.
this
context,
hydrogel
microneedles
have
potential
multifunctional
operation
medical
devices,
avoiding
complications
associated
with
delivery
therapeutics.
Compared
oral
administration
subcutaneous
injection,
advantages
such
better
compliance,
faster
onset
action,
improved
permeability
efficacy.
addition,
they
comprise
highly
biocompatible
polymers
excellent
degradability
tunable
properties.
thus
possibility
expand
through
combined
synergistic
use
their
respective
features.
We
review
herein
recent
advances
concerning
processing
methods
material
requirements
within
realm
platforms,
various
approaches
toward
incorporation
added
functionality.
Graphical
Inorganic Chemistry,
Год журнала:
2024,
Номер
63(28), С. 13059 - 13067
Опубликована: Июнь 28, 2024
Type
I
photosensitizers
offer
an
advantage
in
photodynamic
therapy
(PDT)
due
to
their
diminished
reliance
on
oxygen
levels,
thus
circumventing
the
challenge
of
hypoxia
commonly
encountered
PDT.
In
this
study,
we
present
synthesis
and
comprehensive
characterization
a
novel
type
photosensitizer
derived
from
cyclometalated
Ir(III)-rhodamine
complex.
Remarkably,
complex
exhibits
shift
absorption
fluorescence,
transitioning
"off"
"on"
states
aprotic
protic
solvents,
respectively,
contrary
initial
expectations.
Upon
exposure
light,
demonstrates
effective
generation
O2–
·OH
radicals
via
mechanism.
Additionally,
it
notable
antibacterial
activity
against
both
Gram-positive
Gram-negative
bacteria,
demonstrated
through
vitro
vivo
experiments.
This
research
offers
valuable
insights
for
development
photosensitizers.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 24, 2024
Piezoelectric
materials
can
generate
charges
and
reactive
oxygen
species
(ROS)
under
external
force
stimulation
for
ultrasound-induced
sonodynamic
therapy
(SDT).
However,
their
poor
piezoelectricity,
fast
electron–hole
pair
recombination
rate,
biological
toxicity
of
piezoelectric
limit
the
therapeutic
effects
SDT.
In
this
study,
hollow
ZnO
(HZnO)
nanospheres
were
synthesized
by
using
a
one-step
method.
The
structure
facilitated
deformation
HZnO
ultrasound
mechanical
increased
constant.
Subsequently,
black
phosphorus
quantum
dots
(BPQDs)
arginine-glycine-aspartic
acid
peptide
(RGD)-poly(ethylene
glycol)
(PEG)
combined
with
to
further
enhance
effect
constructing
heterojunctions
enable
tumor-targeting
ability.
During
treatment,
HZnO-BPQDs-PEG
could
degrade
in
an
acidic
tumor
microenvironment
release
Zn2+
PO43–
ions
induce
pro-death
autophagy.
ROS
produced
SDT
also
accelerated
autophagy
promoted
ferroptosis
cancer
cells.
This
study
demonstrates
that
has
strong
effectively
cells,
providing
new
idea
design
application
therapy.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
Abstract
Despite
improvements
in
cancer
survival
rates,
metastatic
and
surgery‐resistant
cancers,
such
as
pancreatic
cancer,
remain
challenging,
with
poor
prognoses
limited
treatment
options.
Enhancing
drug
bioavailability
tumors,
while
minimizing
off‐target
effects,
is
crucial.
Metal–organic
frameworks
(MOFs)
have
emerged
promising
delivery
vehicles
owing
to
their
high
loading
capacity,
biocompatibility,
functional
tunability.
However,
the
vast
chemical
diversity
of
MOFs
complicates
rational
design
biocompatible
materials.
This
study
employed
machine
learning
molecular
simulations
identify
suitable
for
encapsulating
gemcitabine,
paclitaxel,
SN‐38,
identified
PCN‐222
an
optimal
candidate.
Following
loading,
MOF
formulations
are
improved
colloidal
stability
biocompatibility.
In
vitro
studies
on
cell
lines
shown
cellular
internalization,
delayed
release.
Long‐term
tests
demonstrated
a
consistent
performance
over
12
months.
vivo
tumor‐bearing
mice
revealed
that
paclitaxel‐loaded
PCN‐222,
particularly
hydrogel
local
administration,
significantly
reduced
spread
tumor
growth
compared
free
drug.
These
findings
underscore
potential
effective
system
hard‐to‐treat
cancers.
Dual-atom
nanozymes
(DAzymes)
have
garnered
considerable
attention
as
catalysts
for
reactive
oxygen
species
(ROS)-based
therapies,
effectively
leveraging
ROS
generation
within
the
tumor
microenvironment
(TME).
Herein,
we
introduce
FeMn-NCe
DAzymes,
which
are
meticulously
engineered
enhanced
peroxidase
(POD)-mimetic
activity
and
potent
radiosensitization
to
advance
radioimmunotherapy.
Density
functional
theory
(DFT)
calculations
reveal
that
DAzymes
lower
energy
barrier
increase
substrate
affinity,
enabling
highly
efficient
catalytic
performance.
Within
TME,
these
efficiently
convert
overexpressed
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(•OH),
potentially
activating
cGAS-STING
immune
pathway.
This
POD-mimetic
catalysis
is
further
accelerated
under
X-ray
irradiation,
significantly
enhancing
radiosensitization.
Additionally,
a
uniform
coating
of
ultrasmall
gold
nanoparticles
on
enhances
absorption
cancer
cells.
The
incorporation
STING
agonist
diABZI
onto
induces
long-term
antitumor
immunity,
reprograms
immunosuppressive
suppresses
growth
metastasis
following
single
low-dose
treatment.
work
highlights
valuable
strategy
designing
radiodynamic
immunotherapy.
