Acta Pharmaceutica Sinica B,
Год журнала:
2025,
Номер
15(2), С. 792 - 808
Опубликована: Янв. 1, 2025
Atherosclerosis,
a
chronic
inflammatory
disease,
is
markedly
influenced
by
both
immune
and
reactions
throughout
its
progression.
Dendritic
cells,
as
pivotal
antigen-presenting
entities,
play
crucial
role
in
the
initiation
of
responses
preservation
immunological
homeostasis.
Accumulating
data
indicates
that
dendritic
cells
are
present
healthy
arteries
accumulate
significantly
atherosclerotic
plaques.
Novel
immunotherapeutic
approaches
vaccination
protocols
have
yielded
substantial
clinical
advancements
managing
diseases,
with
cell-centric
modalities
emerging
for
management.
In
this
review,
we
delineate
essential
functions
underlying
mechanisms
their
subsets
modulation
inflammation
responses.
We
underscore
immense
promise
cell-based
strategies,
including
vaccines
innovative
combinations
nanotechnological
drug
delivery
platforms
atherosclerosis
treatment.
also
discuss
challenges
associated
cell
immunotherapy
provide
perspectives
on
future
direction
field.
Chemical Reviews,
Год журнала:
2024,
Номер
124(5), С. 2699 - 2804
Опубликована: Фев. 29, 2024
The
ability
to
gain
spatiotemporal
information,
and
in
some
cases
achieve
control,
the
context
of
drug
delivery
makes
theranostic
fluorescent
probes
an
attractive
intensely
investigated
research
topic.
This
interest
is
reflected
steep
rise
publications
on
topic
that
have
appeared
over
past
decade.
Theranostic
probes,
their
various
incarnations,
generally
comprise
a
fluorophore
linked
masked
drug,
which
released
as
result
certain
stimuli,
with
both
intrinsic
extrinsic
stimuli
being
reported.
release
then
signaled
by
emergence
signal.
Importantly,
use
appropriate
fluorophores
has
enabled
not
only
this
emerging
fluorescence
marker
for
but
also
provided
modalities
useful
photodynamic,
photothermal,
sonodynamic
therapeutic
applications.
In
review
we
highlight
recent
work
particular
focus
are
activated
tumor
microenvironments.
We
summarize
efforts
develop
other
applications,
such
neurodegenerative
diseases
antibacterials.
celebrates
diversity
designs
reported
date,
from
discrete
small-molecule
systems
nanomaterials.
Our
aim
provide
insights
into
potential
clinical
impact
still-emerging
direction.
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Июль 14, 2023
Early
detection
and
diagnosis
of
many
cancers
is
very
challenging.
Late
stage
a
cancer
always
leads
to
high
mortality
rates.
It
imperative
develop
novel
more
sensitive
effective
therapeutic
methods
for
treatments.
The
development
new
treatments
has
become
crucial
aspect
medical
advancements.
Nanobots,
as
one
the
most
promising
applications
nanomedicines,
are
at
forefront
multidisciplinary
research.
With
progress
nanotechnology,
nanobots
enable
assembly
deployment
functional
molecular/nanosized
machines
increasingly
being
utilized
in
treatment.
In
recent
years,
various
practical
have
transitioned
from
theory
practice,
vitro
experiments
vivo
applications.
this
paper,
we
review
analyze
advancements
treatments,
with
particular
emphasis
on
their
key
fundamental
features
drug
delivery,
tumor
sensing
diagnosis,
targeted
therapy,
minimally
invasive
surgery,
other
comprehensive
At
same
time,
discuss
challenges
potential
research
opportunities
revolutionizing
future,
expected
sophisticated
capable
performing
multiple
functions
tasks,
ultimately
becoming
true
nanosubmarines
bloodstream.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(18), С. 10322 - 10332
Опубликована: Апрель 25, 2023
Designing
nanozymes
that
match
natural
enzymes
have
always
been
an
attractive
and
challenging
goal.
In
general,
researchers
mainly
focus
on
the
construction
of
metal
centers
control
non-metallic
ligands
nanozyme
to
regulate
their
activities.
However,
this
is
not
applicable
lactate
oxidase,
i.e.,
flavoenzymes
with
flavin
mononucleotide
(FMN)-dependent
pathways.
Herein,
we
propose
a
coordination
strategy
mimic
oxidase
based
engineering
electronic
properties
at
N
center
by
modulating
Co
number
near
in
Cox–N
nanocomposite.
Benefitting
from
manipulated
fields
structure
around
electron-rich
sites,
Co4N/C
possesses
precise
recognition
site
for
intermediate
organization
optimizes
absorption
energies
intermediates,
leading
superior
oxidation
α-C–sp(3)–H
bond
toward
ketone.
The
optimized
delivers
much
improved
anticancer
efficacy
reversing
high
immunosuppressive
state
tumor
microenvironment,
subsequently
achieving
excellent
growth
distant
metastasis
inhibition.
developed
NEs
open
new
window
building
bridge
between
chemical
catalysis
biocatalysis.
Lactic
acid
(LA)
accumulation
in
the
tumor
microenvironment
poses
notable
challenges
to
effective
immunotherapy.
Here,
an
intelligent
treatment
microrobot
based
on
unique
physiological
structure
and
metabolic
characteristics
of
Abstract
It
is
newly
revealed
that
collagen
works
as
a
physical
barrier
to
tumor
immune
infiltration,
oxygen
perfusion,
and
depressor
in
solid
tumors.
Meanwhile,
after
radiotherapy
(RT),
the
programmed
death
ligand‐1
(PD‐L1)
overexpression
transforming
growth
factor‐β
(TGF‐β)
excessive
secretion
would
accelerate
DNA
damage
repair
trigger
T
cell
exclusion
limit
RT
efficacy.
However,
existing
drugs
or
nanoparticles
can
hardly
address
these
obstacles
of
highly
effective
simultaneously,
effectively,
easily.
In
this
study,
it
inducing
mitochondria
dysfunction
by
using
oxidative
phosphorylation
inhibitors
like
Lonidamine
(LND)
serve
multi‐immune
pathway
regulation
strategy
through
PD‐L1,
collagen,
TGF‐β
co‐depression.
Then,
IR‐LND
prepared
combining
mitochondria‐targeted
molecule
IR‐68
with
LND,
which
then
loaded
liposomes
(Lip)
create
IR‐LND@Lip
nanoadjuvants.
By
doing
this,
more
effectively
sensitizes
generating
cold
tumors
into
hot
ones
activation
co‐inhibition.
conclusion,
combined
treatment
ultimately
almost
completely
suppressed
bladder
breast
Tumor
suppressor
p53
can
transcriptionally
activate
downstream
genes
in
response
to
stress,
and
then
regulate
the
cell
cycle,
DNA
repair,
metabolism,
angiogenesis,
apoptosis,
other
biological
responses.
has
seven
functional
domains
12
splice
isoforms,
different
subtypes
play
roles.
The
activation
inactivation
of
are
finely
regulated
associated
with
phosphorylation/acetylation
modification
ubiquitination
modification,
respectively.
Abnormal
is
closely
related
occurrence
development
cancer.
While
targeted
therapy
signaling
pathway
still
its
early
stages
only
a
few
drugs
or
treatments
have
entered
clinical
trials,
new
ongoing
trials
expected
lead
widespread
use
signaling-targeted
cancer
treatment
future.
TRIAP1
novel
inhibitor
apoptosis.
homolog
yeast
mitochondrial
intermembrane
protein
MDM35,
which
tumor-promoting
role
by
blocking
mitochondria-dependent
apoptosis
pathway.
This
work
provides
systematic
overview
recent
basic
research
progress
proposes
that
an
important
therapeutic
target
signaling.
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(19), С. 2575 - 2602
Опубликована: Май 17, 2024
Lactate,
previously
considered
a
metabolic
byproduct,
is
pivotal
in
cancer
progression
and
maintaining
the
immunosuppressive
tumor
microenvironment.
Further
investigations
confirmed
that
lactate
primary
regulator,
introducing
recently
described
post-translational
modifications
of
histone
non-histone
proteins,
termed
lysine
lactylation.
Pancreatic
adenocarcinomas
are
characterized
by
increased
glycolysis
accumulation.
However,
our
understanding
lactylation-related
genes
pancreatic
remains
limited.
